Tiamulin hydrogen famarate premixing agent and preparing method thereof

Abstract

The invention provides a tiamulin hydrogen famarate premixing agent. The tiamulin hydrogen famarate premixing agent is prepared from, by mass, 75-85% of tiamulin hydrogen famarate and 15-25% of lacticacid. The invention further provides a preparing method of the tiamulin hydrogen famarate premixing agent. The tiamulin hydrogen famarate premixing agent can treat pig bacillary enteritis, bacterialpneumonia and treponema swine dysentery and has obvious therapy effects on mycoplasmal pneumonia and pneumonia which is caused by mixed infection of bordetella bronchiseptica and pasteurella multocida, during preparation, conventional equipment is adopted, the preparing method is simple, the substance cost is low, and the preparing method is suitable for industrial large-batch production of the livestock antibiotic premixing agent.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a tiamulin fumarate premix and a preparation method thereof. Background technique [0002] Mycocin has good antibacterial activity against Mycoplasma and Treponema hyodysenteriae, and also has good antibacterial activity against most Gram-positive bacteria including Staphylococcus and Streptococcus (except Group D Streptococcus). It has a certain effect on Actinobacillus pleuropneumoniae, and has weak antibacterial activity against most Gram-negative bacteria. [0003] For the preparation of antibiotic premixes, the purpose is to disperse a certain amount of powdered antibiotics into a suitable dispersion medium to make a granular preparation with suitable particle size and density that can be evenly mixed with feed, so that it can be conveniently used in poultry. Administration to animals in the treatment of veterinary diseases. For tiamulin fumarate AP...

AI Technical Summary

Problems solved by technology

The one-step fluidized bed granulation method has high requirements for production equipment, similar particle size and density requirements for raw and auxiliary materials, and complex requirements for process control points, so only a few types of auxiliary materials, such as lactose, are limited.

The use of tiamulin fumarate premix prepared with medicinal lactose as a dispersion system may cause lactose intolerance to animals. According to individual tolerance differences, some animals may experience symptoms such as anorexia and vomiting after administration. Conducive to meat and egg production

Combined with the high price of medicinal lactose, it increases the complexity and cost of production, which is not conducive to large-scale production and export of domestic enterprises

[0004] At this stage, various enterprises and scientific research institutes have conducted many researches on tiamulin products, but the research progress is slow, and the defects of tiamulin-related products cannot be effectively improved. However, the shortcomings of tiamulin, such as bad smell, strong hygroscopicity, high irritation, relatively poor stability and difficult storage, have not been effectively solved, and the comprehensive indicators are still difficult to reach satisfactory standards. Therefore, It is urgent to develop a new tiamulin product to improve the existing defects

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