Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Flexible stripped uric acid sensor capable of detecting body fluid in real time, and preparation method thereof

A technology of real-time detection and flexible strips, applied in the field of flexible sensors, can solve problems such as enzyme durability, and achieve the effects of small size, simple and easy-to-obtain materials, and easy-to-control conditions

Active Publication Date: 2019-05-17
厦门柯迪森科技有限公司
View PDF8 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, enzyme electrochemical technique is the most acceptable method for clinical analysis of UA, but it has some disadvantages, such as durability problems due to the inactivation of enzymes, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Flexible stripped uric acid sensor capable of detecting body fluid in real time, and preparation method thereof
  • Flexible stripped uric acid sensor capable of detecting body fluid in real time, and preparation method thereof
  • Flexible stripped uric acid sensor capable of detecting body fluid in real time, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] The present invention also provides a method for preparing the above-mentioned flexible strip-shaped uric acid sensor capable of real-time detection of body fluids, comprising the following steps:

[0041] Step 1, preparing the counter electrode 23 , the working electrode 21 and the reference electrode 22 on the surface of the flexible substrate 1 .

[0042] Further, the flexible substrate 1 is selected from one or more composites of polyvinyl chloride, polycarbonate, polyethylene terephthalate, polyester, paper, cardboard, ceramics, and regenerated silk fibroin things.

[0043] More preferably, in a preferred embodiment of the present invention, the strip-shaped polyethylene terephthalate (PET) material is selected as the base material, which has excellent physical and mechanical properties in a wide temperature range. Performance, the long-term use temperature can reach 120 ℃, has excellent flexibility, electrical insulation, fatigue resistance, friction resistance a...

Embodiment 1

[0075] This embodiment provides a flexible strip-shaped uric acid sensor that can detect body fluids in real time, which is made according to the following steps:

[0076] (1) Get the wool keratin solution of 5ml 5wt%, add HAuCl under vigorous stirring condition 4 solution, and then add 1M sodium hydroxide solution under constant stirring conditions, adjust the pH value to 12, and then place it at 38°C for 12h. Among them, wool keratin and HAuCl in the reaction solution 4 The mass ratio is 100:1.

[0077] (2) The reaction solution was placed at -80° C. for 48 hours of freeze-drying to obtain gold nanoparticles@wool keratin.

[0078] (3) Carbonization: under an argon atmosphere, the gold nanoparticle@wool keratin was heated to 150° C. at a heating rate of 2° C. / min and maintained for 3 hours. Then the temperature was raised to 350°C at a rate of 5°C / min and kept for 3h, and then the temperature was raised to 700°C at a rate of 5°C / min and kept for 2h. Finally, take it out a...

Embodiment 2

[0083] This embodiment provides a flexible strip-shaped uric acid sensor that can detect body fluids in real time. The difference from Embodiment 1 is that:

[0084] In step (1), take 5ml of 5wt% silk fibroin solution as the protein base in the protein base nitrogen-doped carbon / gold nanoparticle composite material.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Lengthaaaaaaaaaa
Widthaaaaaaaaaa
Lengthaaaaaaaaaa
Login to View More

Abstract

The invention provides a flexible stripped uric acid sensor capable of detecting body fluid in real time, and a preparation method thereof, and relates to the field of the flexible sensor. The preparation method comprises arranging a detection electrode module on a flexible substrate, the detection electrode module comprises a counter electrode, a working electrode and a reference electrode orderly arranged from top to bottom in parallel, and three electrodes are mutually parallel and free from contacting with each other; two ends of each of the counter electrode, the working electrode and thereference electrode are a working area and an electrode connecting area, the working areas of the three electrodes are located at the same side, and insulating layers are covered on middle parts of the three electrodes, thereby enabling the working areas of the three electrodes to insulate from the electrode connecting areas thereof; the nitrogen-doped carbon material of the load metal nano-particles sensitive to the uric acid is covered on the working area of the working electrode. The substrate of the uric acid sensor is made of a flexible insulating material, the sensitivity is high, and the flexibility is good; compared with the enzyme sensor, the enzyme inactivation and like defects can be avoided, the preparation condition is simple, and the condition is easy to control.

Description

technical field [0001] The invention relates to the field of flexible sensors, and in particular to a flexible strip-shaped uric acid sensor capable of real-time detection of body fluids and a preparation method thereof. Background technique [0002] Biomarkers Body fluids play a huge role in medical diagnosis. Most biological indicators are extracted from human secretions. Uric acid (UA) (2,4,6-trihydroxypurine), which is the final metabolite derived from purine derivatives and excreted by the kidney, is one of the important biological indicators. Abnormal uric acid concentration in body fluids is a signal of many clinical diseases, such as gout, kidney disease and cardiovascular disease. Therefore, rapid, accurate and reliable detection of uric acid in body fluids is a must for diagnosis and treatment. [0003] Currently, reliable techniques available for uric acid detection are chemiluminescent, chromatographic, and electrochemical techniques. Among them, the enzyme e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N27/416G01N27/30G01N27/327
Inventor 刘向阳安尼如德·帕蒂尔吴荣辉孟照辉马丽芸刘强邱武
Owner 厦门柯迪森科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com