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Ureter stent tube capable of degrading long-acting antibacterial and preparation method thereof

A ureteral stent tube, a long-acting technology, applied in medical science, surgery and other directions, can solve the problems of ineffective combination of antibacterial agents and materials, high requirements on tube wall and mechanical properties, and reducing the antibacterial validity period of the stent tube, etc. Moderate, significant antibacterial, long antibacterial effect

Active Publication Date: 2019-05-17
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the ureteral stent has high requirements on the tube wall and mechanical properties, the porosity of the polymer material used is low, and the loading capacity of antibacterial agents is extremely limited.
In addition, the antibacterial agent is not effectively combined with the material, and after implantation in the body, it is prone to burst release, resulting in certain biological toxicity and reducing the antibacterial validity period of the stent.

Method used

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  • Ureter stent tube capable of degrading long-acting antibacterial and preparation method thereof
  • Ureter stent tube capable of degrading long-acting antibacterial and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] like figure 1 As shown, this embodiment provides a long-acting antibacterial and degradable ureteral stent tube, and the specific preparation steps are as follows:

[0040] Step 1: select deionized water as the dispersant, select nano-silver with a particle size of 30-50 nm as the antibacterial agent, and ultrasonically disperse for 30 minutes to prepare an antibacterial agent dispersion with an antibacterial agent concentration of 1 wt %;

[0041] Step 2: Weave PGLA910 multifilament (provided by Shanghai Tianqing Biomaterials Co., Ltd., specification 36dtex / 12f) regularly using a 24-spindle braiding machine with a braiding angle of 60°, a tightness of 90%, and a diameter of 1.6mm , a tubular fabric with a length of 25 cm, ultrasonically cleaned for 10 minutes, dried naturally at room temperature, and set aside;

[0042] Step 3: Immerse the tubular fabric obtained in step 2 into the antibacterial agent dispersion obtained in step 1. Under the wicking action and capilla...

Embodiment 2

[0049] like figure 1 As shown, this embodiment provides a long-acting antibacterial and degradable ureteral stent tube, and the specific preparation steps are as follows:

[0050] Step 1: select deionized water as the dispersant, select nano-zinc oxide with a particle size of 20 to 50 nm as the antibacterial agent, and ultrasonically disperse for 30 minutes to prepare an antibacterial agent dispersion with an antibacterial agent concentration of 2 wt %;

[0051] Step 2: PGA multifilament (provided by Shanghai Tianqing Biomaterials Co., Ltd., specification 36dtex / 12f), using a 24-spindle braiding machine, weaves regularly, the braiding angle is 60°, the tightness is 90%, and the diameter is 1.8mm , a tubular fabric with a length of 25 cm, ultrasonically cleaned for 10 minutes, dried naturally at room temperature, and set aside;

[0052] Step 3: Immerse the tubular fabric obtained in step 2 into the antibacterial agent dispersion obtained in step 1. Under the wicking action and...

Embodiment 3

[0059] like figure 1 As shown, this embodiment provides a long-acting antibacterial and degradable ureteral stent tube, and the specific preparation steps are as follows:

[0060] Step 1: select deionized water as the dispersant, select nano-gold-silver alloy with a particle size of 20-50 nm as the antibacterial agent, and disperse ultrasonically for 30 minutes to prepare an antibacterial agent dispersion with an antibacterial agent concentration of 2 wt %;

[0061] Step 2: Weave PGLA730 multifilament (provided by Shanghai Tianqing Biomaterials Co., Ltd., specification 30dtex / 20f) regularly using a 24-spindle braiding machine with a braiding angle of 60°, a tightness of 110%, and a diameter of 1.8mm , a tubular fabric with a length of 25 cm, ultrasonically cleaned for 10 minutes, dried naturally at room temperature, and set aside;

[0062] Step 3: Immerse the tubular fabric obtained in step 2 into the antibacterial agent dispersion obtained in step 1. Under the wicking action...

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Abstract

The invention provides a ureter stent tube capable of degrading long-acting antibacterial and a preparation method thereof. The ureter stent tube body is a membrane structure and an antibacterial agent whose loading amount is 0.01-5wt% is uniformly distributed inside and on the surface of the stent tube body. The preparation method comprises the following steps of: preparing the degradable fiber into a tubular fabric with uniform wall thickness and regular texture, soaking the tubular fabric in an antibacterial agent dispersion liquid, under the wicking action and the capillary action of a fiber aggregate, filling pores in the fabric with the antibacterial agent dispersion liquid, taking out, drying and repeating for a plurality of times, and then fixing the tubular fabric on a core mold,hot-melting the fabric to form a film by means of heat treatment, and pulling out the core rod after cooling to obtain the degradable ureter stent tube loaded with the antibacterial agent. The invention has the advantages of simple preparation, controllable loading amount of the antibacterial agent, uniform distribution, effective embedding of the antibacterial agent and the bracket body, no burstrelease phenomenon after being implanted into the body, long-acting antibacterial effect and better biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of medical materials and medical devices, and in particular relates to a long-acting antibacterial and degradable ureteral stent tube and a preparation method thereof. Background technique [0002] Ureteral stent has dual functions of internal drainage and internal stent. It is a common drainage tool in urology. It is mainly used for dilation treatment of renal ureteral stones, hydronephrosis, ureteral tumors, kidney transplantation and ureteral stricture. [0003] The indwelling time of the ureteral stent is generally 4 weeks, and the existing clinical ureteral stents are all non-degradable polyurethane stents. After 4 weeks, a second operation is required to remove the stent, which will damage the patient's urinary system. If the stent is placed for a long time, it will lead to more serious consequences, such as the loss of renal function, and even the need to remove the kidney. Bring physical, mental and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/06A61L31/14A61L31/16
Inventor 王璐高立恒邹婷王富军李沂蒙
Owner DONGHUA UNIV
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