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Solution preparation for treating cough and atomizing inhalation of ginseng and wheat and preparation method thereof

An aerosol inhalation and cough-relieving technology, which is applied in the field of formulations, can solve the problems of difficulty in meeting clinical needs, lack of a solution formulation for inhalation of Shenmai Zhi gargle, and the like, achieving improved safety, fast onset of action, and reduced distribution. Effect

Inactive Publication Date: 2019-05-14
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] To sum up, as a new dosage form, Shenmaizhisou aerosolized inhalation solution preparation has faster onset of action and higher bioavailability than traditional dosage forms, and has broad clinical application prospects. However, it is currently used to treat bronchial diseases. There are fewer inhalation products, and there is no special formulation of Shenmai Zhigargle nebulized inhalation solution, so it is difficult to meet the growing clinical needs

Method used

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  • Solution preparation for treating cough and atomizing inhalation of ginseng and wheat and preparation method thereof
  • Solution preparation for treating cough and atomizing inhalation of ginseng and wheat and preparation method thereof
  • Solution preparation for treating cough and atomizing inhalation of ginseng and wheat and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0044]

[0045] The preparation method is as follows:

[0046] Weigh according to the above prescription, add water and decoct twice for 1.5 hours each time, combine the filtrate, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 40%, stir well, let it stand for 12 hours, filter, and recover the ethanol to nothing mellow. Add water to boil, stand for 32 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 60%, stir well, let stand for 12 hours, filter, recover ethanol until there is no alcohol smell, add water, and then add 0.1% activated carbon, Boil for 10 minutes, let it cool and filter, refrigerate for 12 hours, filter, add water for injection to 980ml, add 40g of mannitol, dissolve, add water for injection to 1000ml, adjust pH to 6.0, ultrafilter, potting, and sterilize to obtain the present invention solution formulations.

Embodiment 2

[0048]

[0049] The preparation method is as follows:

[0050] Weigh according to the above prescription, add water and decoct twice for 1.8 hours each time, combine the filtrate, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 45%, stir well, let it stand for 15 hours, filter, and recover the ethanol to nothing mellow. Add water, boil, stand still for 38 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 65%, stir well, let stand for 15 hours, filter, recover ethanol until there is no alcohol smell, add water, and then add 0.2% activated carbon , boil for 15 minutes, let it cool and filter, refrigerate for 15 hours, filter, add water for injection to 980ml, add 12g sodium chloride, dissolve, add water for injection to 1000ml, adjust pH to 7.0, ultrafilter, potting, sterilize, that is Solution formulations of the present invention.

Embodiment 3

[0052]

[0053] The preparation method is as follows:

[0054] Weigh according to the above prescription, add water and decoct 3 times, 1.5 hours each time, combine the filtrate, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 50%, stir well, let it stand for 20h, filter, and recover the ethanol until it is free mellow. Add water to boil, stand for 40 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content reach 70%, stir well, let stand for 18 hours, filter, recover ethanol until there is no alcohol smell, add water, and then add 0.3% activated carbon, Boil for 20 minutes, let it cool and filter, refrigerate for 18 hours, filter, add water for injection to 980ml, add 15g of sodium chloride, dissolve, add water for injection to 1000ml, adjust the pH to 7.6, ultrafilter, potting, and sterilize to obtain the product Invented solution formulation.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a solution preparation for treating cough and atomizing inhalation of ginseng and wheat and a preparation method thereof. The solution preparation comprises: (1) effective components of the ginseng and wheat for treating cough; (2) an isotonic agent and a solvent; wherein each liter of the atomizing inhalation solution preparation comprises the ginseng and wheat cough-treating effective components prepared from the following raw materials: 20-85g of radix glehniae, 40-220g of radix ophiopogonis, 50-270g of sanguisorba stem, 50-300g of loquat leaf and 30-220g of cordate houttuynia. According to the solution preparation for treating cough and atomizing inhalation of the ginseng and wheat,effective components of the medicament are dissolved in a proper medium, and are delivered to the respiratory tract or the lung in the form of aerosol by oral inhalation or nasal inhalation through an atomizer, and the medicament is directly administered to the acting part, so that the distribution of the medicament in other tissues and organs is reduced; compared with oral administration, the treatment total effective rate of the atomization inhalation administration mode is greatly improved; the preparation method has the advantages of safety and effectiveness, high bioavailability and small toxic and side effects, thereby having obvious advantages.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a solution preparation for nebulization and inhalation of Shenmai Zhikou and a preparation method thereof. Background technique [0002] Shenmai anti-cough preparation is extracted and refined from the prescriptions of Adenophora, Ophiopogon japonicus, Maimateng, loquat leaves, and Houttuynia cordata. The scope of clinical application continues to expand. Shenmai Zhisou preparation is also used for the treatment of lung dryness cough, acute and chronic bronchitis. At present, Shenmai Zhisou preparation only has one dosage form, Shenmai Zhigargle Syrup, because it is effective for acute and chronic bronchitis. The therapeutic effect is obvious, and more and more attention has been paid to it clinically. [0003] With the increase of the clinical drug population, a single dosage form is difficult to meet the clinical needs. In addition, due to the sugar and other nutrients in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/72A61P11/14A61P11/10A61P11/00
Inventor 张保献胡杰
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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