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Application of polyketone compound in herbicides

A technology of polyketides and herbicides, applied in the direction of herbicides and algicides, applications, biocides, etc., can solve the problems of unreported phytotoxic activity

Inactive Publication Date: 2019-05-07
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Activity studies have found that polyketides have cytotoxic and anti-inflammatory activities, but their phytotoxic activities have not been reported

Method used

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  • Application of polyketone compound in herbicides
  • Application of polyketone compound in herbicides
  • Application of polyketone compound in herbicides

Examples

Experimental program
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Effect test

preparation example Construction

[0036] In the present invention, the preparation method of the compound having the structure shown in formula I preferably includes the following steps:

[0037] Cultivating endophytic fungi on a solid medium to obtain a fermentation product;

[0038] The fermentation product is mixed with an organic extraction solvent and then organically extracted to obtain a total extract;

[0039] The total extract is subjected to silica gel adsorption and elution in sequence, combined with thin layer analysis to obtain the corresponding subcomponents;

[0040] The corresponding subcomponents are sequentially subjected to chromatographic column separation and solvent evaporation to obtain a compound having the structure shown in formula I.

[0041] In the present invention, the plant endophytic fungus is preferably cultured on a solid medium to obtain a fermentation product.

[0042] In the present invention, the plant endophytic fungus is preferably Chaetomium cochliodes VTh01, Chaetomi...

Embodiment 1

[0091] Preparation of AL-9

[0092] Source of bacteria:

[0093] The fungus used is the plant endophyte Chaetomium globosum.

[0094] 1) fermentation

[0095] First prepare the solid medium for fungal fermentation. The specific formula is to add 60g of rice and 80mL of distilled water to a 500mL conical flask, and then autoclave at 121°C for 30 minutes for later use; For the amplification of strains, inoculate the amplified bacteria blocks on the rice medium for fermentation) and cut the fungi in the logarithmic phase into small pieces, inoculate them on the rice medium in the ultra-clean workbench for co-fermentation 50 bottles. Leave to ferment at room temperature for 15 days.

[0096] 2) Preparation of polyketide crude fraction from endophytic fungus Chaetomium globosum

[0097] After the fermentation of the above-mentioned strains is completed, obtain a solid fermentation product, soak the solid fermentation product with ethyl acetate, extract three times, reclaim the...

Embodiment 2

[0107] Preparation of AL-10

[0108] Dissolve the component Fr.E.I-D obtained in step 2) of Example 1 with chromatographic methanol, centrifuge, and pass through a 0.22 μm filter membrane for later use. The liquid chromatography conditions are 85% methanol to 15% water, and collect t R The chromatographic peak was 13.1 min. After the collection was completed, the preparation liquid was evaporated to dryness with a rotary evaporator to obtain monomer compound AL-10 (purity higher than 95%). After the samples were evaporated to dryness, some of the dried samples were taken out for NMR and mass spectrometry tests. The structure of compound AL-10 was identified by means of high-resolution mass spectrometry and one-dimensional and two-dimensional nuclear magnetic resonance.

[0109] AL-10: HR-ESI-MS (m / z433.1418[M+H] + , calcd.433.1418)

[0110] Nuclear magnetic resonance (1D and 2DNMR) further confirmed the compound structure: 1H-NMR (500MHz, CDCl 3 )δ8.70 (s, H-1), 6.62 (dd, ...

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Abstract

The invention relates to the technical field of pharmaceutical compounds, in particular to application of a polyketone compound in herbicides. The compound with a structure shown as formula I providedby the invention or a physiologically acceptable salt thereof has phytotoxicity, and can be used as the effective component of herbicides. The results of the embodiments indicate that the polyketonecompound provided by the invention has an inhibiting effect on rooting of arabidopis thaliana.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compounds, in particular to the application of a polyketide compound in herbicides. Background technique [0002] Farmland weeds refer to those herbaceous plants other than crops that grow in fields and fields. It has survived for a long time by adapting to local crops, cultivation, climate, soil and other ecological conditions and other social factors, and is an integral part of the agricultural ecosystem. Weeds have well-developed root systems, strong absorption capacity, fast growth at the seedling stage, and high photosynthetic efficiency, which seriously interferes with the growth of crops. Many weeds are also intermediate hosts of crop pathogens, viruses or pests, and can spread diseases and pests. [0003] Weeds have strong growth ability, and chemical weeding is still one of the main means of controlling weeds. At present, chemical herbicides are mainly divided into seven categor...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01P13/00
Inventor 丁刚张晓燕孙炳达邹忠梅
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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