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Application of 10-membered ring lactone-containing compound in herbicide

A technology of ester compounds and ten-membered rings, which is applied in the application field of herbicides containing ten-membered ring lactones, and can solve the problems of unreported phytotoxicity

Active Publication Date: 2018-12-07
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Activity studies have found that ten-membered ring lactones have cytotoxic and anti-inflammatory activities, but their phytotoxic activities have not been reported

Method used

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  • Application of 10-membered ring lactone-containing compound in herbicide
  • Application of 10-membered ring lactone-containing compound in herbicide
  • Application of 10-membered ring lactone-containing compound in herbicide

Examples

Experimental program
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Effect test

preparation example Construction

[0035] In the present invention, the preparation method of the compound having the structure shown in formula I preferably includes the following steps:

[0036] 1) Cultivating endophytic fungi on a solid medium to obtain a fermentation product;

[0037] 2) performing organic extraction after mixing the fermentation product obtained in step 1) with an organic extraction solvent to obtain the total extract;

[0038] 3) The total extract obtained in step 2) is sequentially subjected to silica gel adsorption and elution, combined with thin layer analysis to obtain corresponding subcomponents;

[0039] 4) The corresponding subcomponents obtained in step 3) are sequentially subjected to chromatographic column separation and solvent evaporation to obtain a compound having the structure shown in formula I.

[0040] In the invention, the plant endophytic fungus is cultivated on a solid medium to obtain a fermentation product.

[0041] In the present invention, the plant endophytic f...

Embodiment 1

[0091] Preparation of TS-1

[0092] Source of bacteria:

[0093] The fungus used is the plant endophytic fungus Chaetosphaeronemahispidulur.

[0094] 1) fermentation

[0095] First prepare the solid medium for fungal fermentation. The specific formula is to add 60g of rice and 80mL of distilled water to a 500mL conical flask, and then autoclave at 121°C for 30 minutes for later use; For the amplification of strains, inoculate the amplified bacterial mass on the rice medium for fermentation) and cut the fungi in the logarithmic phase into small pieces, inoculate them on the rice medium in the ultra-clean workbench, A total of 50 bottles were fermented. Leave to ferment at room temperature for 30 days.

[0096] 2) Preparation of Crude Fraction of Ten-membered Ring Macrolide from Plant Endophytic Fungus Chaetosphaeronemahispidulur

[0097] After the fermentation of the above-mentioned strains is completed, obtain a solid fermentation product, soak the solid fermentation prod...

Embodiment 2

[0105] Preparation of TS-2

[0106] The component Fr-D obtained in Example 1 was dissolved in chromatographic methanol, centrifuged, and passed through a 0.22 μm filter membrane for use. The liquid chromatography conditions were 80% methanol-20% water, and the collected t R It is the chromatographic peak at 27.1 min. After the collection is completed, the preparation solution is evaporated to dryness with a rotary evaporator to obtain monomer compound TS-2 (purity higher than 95%). After the samples were evaporated to dryness, some of the dried samples were taken out for NMR and mass spectrometry tests. The structure of compound TS-2 was identified by means of high-resolution mass spectrometry and one-dimensional and two-dimensional nuclear magnetic resonance.

[0107] TS-2: white crystal, HR-ESI-MS (m / z250.1189[M] + , calcd.250.1205)

[0108] Nuclear magnetic resonance (1D and 2DNMR) further confirmed the compound structure: 1H-NMR (500MHz, CDCl 3 )δ11.58(s, 1H, OH-11), 6...

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Abstract

The invention provides an application of a compound having a structure shown as a formula I or a physiologically acceptable salt thereof in a herbicide which belongs to the technical field of pharmaceutical compounds, wherein R1, R2 and R3 independently represent hydrogen, a hydroxyl group, a methoxy group or an oxyethyl group. A 10-membered ring lactone-containing compound provided by the invention has phytotoxicity and can be used as an effective constituent of the herbicide. Results of embodiments show that the 10-membered ring lactone-containing compound has an inhibiting effect on rootingof arabidopsis thaliana, barnyard grass and seeds of digitaria sanguinalis.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compounds, in particular to the application of a ten-membered ring lactone compound in herbicides. Background technique [0002] Farmland weeds refer to those herbaceous plants other than crops that grow in fields and fields. It has survived for a long time by adapting to local crops, cultivation, climate, soil and other ecological conditions and other social factors, and is an integral part of the agricultural ecosystem. Many weeds have well-developed root systems, strong absorption capacity, fast growth at the seedling stage, and high photosynthetic efficiency, which seriously interfere with the growth of crops. Many weeds are also intermediate hosts of crop pathogens, viruses or pests, and can spread diseases and pests. [0003] Weeds have strong growth ability, and chemical weeding is still one of the main means of controlling weeds. At present, chemical herbicides are mainly divided...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/22A01P13/00
CPCA01N43/22
Inventor 丁刚张晓燕孙炳达
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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