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Micron macromolecular particle based on low eutectic solvent emulsion and preparation method thereof

A technology of deep eutectic solvent and polymer particles, which is applied to the preparation of microspheres, medical preparations of non-active ingredients, microcapsules, etc., can solve the problems that cannot be applied to the preparation of unstable drug microcapsules, and achieves simple methods and low cost of raw materials Effects that are cheap and easy to get

Active Publication Date: 2019-04-30
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking O / W and W / O single emulsion as an example, both need to use a deep eutectic solvent phase, which is not suitable for the preparation of unstable drug microcapsules in water

Method used

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  • Micron macromolecular particle based on low eutectic solvent emulsion and preparation method thereof
  • Micron macromolecular particle based on low eutectic solvent emulsion and preparation method thereof
  • Micron macromolecular particle based on low eutectic solvent emulsion and preparation method thereof

Examples

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Embodiment 1

[0040] In the present embodiment, based on the micron polymer particle preparation method of deep eutectic solvent emulsion, its emulsion oil phase is the solution of the PMMA of 1.5wt% in dichloromethane, and the deep eutectic solvent phase is that the molar ratio is 1:1 chlorine Deep eutectic solvent of acetylated choline and DL-malic acid. The antisolvent is absolute ethanol.

[0041] Step 1: Preparation of a deep eutectic solvent phase. Take by weighing 25.5 grams of choline chloride and 24.50 grams of DL-malic acid in a molar ratio of 1:1 and mix them, place them in a 393K oven until a transparent homogeneous solution is formed, and obtain the deep eutectic solvent as the deep eutectic solvent phase of the emulsion;

[0042] Step 2: Prepare the oil phase. Prepare 5 grams of the solution of PMMA in dichloromethane of 1.5wt% as oily phase;

[0043] Step 3: Prepare the emulsion. Take the oil phase in step 2 and add it to the deep eutectic solvent phase in step 1 to obtai...

Embodiment 2

[0048] In this example, the method for preparing micron polymer particles based on a deep eutectic solvent emulsion, the oil phase of the emulsion is a solution of 1.5wt% PLGA dissolved in methylene chloride, and the deep eutectic solvent phase is a 1:1 molar ratio Deep eutectic solvent of choline chloride and DL-malic acid. The antisolvent is absolute ethanol.

[0049] Step 1: Preparation of a deep eutectic solvent phase. Take by weighing 25.5 grams of choline chloride and 24.50 grams of DL-malic acid in a molar ratio of 1:1 and mix them, place them in a 393K oven until a transparent homogeneous solution is formed, and obtain the deep eutectic solvent as the deep eutectic solvent phase of the emulsion;

[0050] Step 2: Prepare the oil phase. Prepare 5 grams of the solution of 1.5wt% PLGA in dichloromethane as the oil phase;

[0051] Step 3: Prepare the emulsion. Take the oil phase in step 2 and add it to the deep eutectic solvent phase in step 1 to obtain a two-phase laye...

Embodiment 3

[0056] In the present embodiment, based on the micron polymer particle preparation method of deep eutectic solvent emulsion, its emulsion oil phase is the solution of dissolving 1.5wt% PMMA in ethyl acetate, and the deep eutectic solvent phase is that the molar ratio is 1:1 Deep eutectic solvent of choline chloride and DL-malic acid. The antisolvent is deionized water.

[0057] Step 1: Preparation of a deep eutectic solvent phase. Take by weighing 25.5 grams of choline chloride and 24.50 grams of DL-malic acid in a molar ratio of 1:1 and mix them, place them in a 393K oven until a transparent homogeneous solution is formed, and obtain the deep eutectic solvent as the deep eutectic solvent phase of the emulsion;

[0058] Step 2: Prepare the oil phase. Prepare 5 grams of the solution of PMMA in ethyl acetate of 1.5wt% as oily phase;

[0059] Step 3: Prepare the emulsion. Take the oil phase in step 2 and add it to the deep eutectic solvent phase in step 1 to obtain a two-phas...

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Abstract

The invention discloses a micron macromolecular particle based on a low eutectic solvent emulsion and a preparation method thereof. A low eutectic solvent is a continuous phase and a macromolecular solution is a dispersed phase. The low eutectic solvent is a low eutectic solvent prepared with choline chloride as a hydrogen bond acceptor and DL-malic acid as a hydrogen bond donor; the macromoleculeis polymethyl methacrylate or a poly(lactic acid)-hydroxyacetic acid copolymer. The novel green solvent-low eutectic solvent is used as the continuous phase of the emulsion, a surfactant does not need to be used, the raw materials are cheap and easy to obtain, and the method is simple and has low toxicity and environmental protection. Through selection of an antisolvent, an 'anhydrous' method canbe extended, and is especially suitable for preparation of macromolecular microcapsules of unstable drugs in water.

Description

technical field [0001] The invention relates to a micron polymer particle based on a deep eutectic solvent emulsion and a preparation method thereof, especially suitable for the preparation of polymer microcapsules of unstable drugs in water, and belongs to the technical field of polymer micron material preparation. Background technique [0002] Emulsion-based solvent evaporation and solvent extraction are important methods for preparing polymer microparticles and microcapsules, which are widely used in medicine, food, spices and other fields. Common emulsions include single or double emulsions. Among them, single milk mainly includes: O / W, W / O and O / O. [0003] Taking O / O single milk as an example, a large amount of organic solvents need to be used, and their residues in the product may have toxic effects on the human body. Taking O / W and W / O single emulsions as examples, both require the use of a deep eutectic solvent phase, which is not suitable for the preparation of u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02A61K9/50A61K47/32A61K47/34
CPCA61K9/5026A61K9/5031B01J13/02
Inventor 刘昆蒲明东邵晓挺姚苌程震
Owner HEFEI UNIV OF TECH
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