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Broiler intestinal mucosa repair agent

A technology of intestinal mucosa and repair agent, which is applied in the field of broiler intestinal mucosa repair agent, to achieve the effect of protecting mitochondrial function, improving the level of mitophagy, and promoting the repair of intestinal mucosa

Active Publication Date: 2021-10-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, the research on repairing damaged intestinal mucosa from the perspective of regulating mitophagy and mitochondrial function has not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0022] preparation:

[0023] 1) Grinding the montmorillonite mineral to 300 mesh, adding water and stirring evenly to make a suspension slurry with a concentration of 1wt.%.

[0024] 2) Slowly add zinc sulfate with a zinc content of 2% by weight of montmorillonite into the suspension slurry in step 1) under stirring, detect and adjust the pH value of the slurry to 3.0, and react at room temperature for 5 hours to detect the pH value of the slurry , adjusted with sodium hydroxide solution, so that the slurry pH value is 8.0;

[0025] 3) Select centrifugation or filtration to dehydrate the suspended slurry;

[0026] 4) Dry the filter cake obtained in step 3) at a temperature of 60° C., grind it to 300 mesh, and obtain 2 wt.% zinc-loaded montmorillonite with a content of zinc in the montmorillonite.

[0027] Take 0.5 kg of ellagic acid, 0.5 kg of L-carnitine, 1 kg of thymol, and 8 kg of zinc-loaded montmorillonite, mix them well, and then get a broiler intestinal mucosa repair ...

Embodiment 2

[0034] preparation:

[0035] 1) Grinding the montmorillonite mineral to 300 mesh, adding water and stirring evenly to make a suspension slurry with a concentration of 10wt.%.

[0036] 2) Slowly add zinc nitrate with a zinc content of 1% by weight of montmorillonite into the suspension slurry in step 1) under stirring, detect and adjust the pH value of the slurry to 4, react at room temperature for 6 hours, and detect the pH value of the slurry , adjusted with sodium hydroxide solution, so that the pH of the slurry is 8.5;

[0037] 3) Select centrifugation or filtration to dehydrate the suspended slurry;

[0038] 4) Dry the filter cake obtained in step 3) at a temperature of 60° C., grind it to 300 mesh, and obtain 1 wt.% zinc-loaded montmorillonite with a content of zinc in the montmorillonite.

[0039] Take 1 kg of ellagic acid, 1.5 kg of L-carnitine hydrochloride, 3 kg of thymol, and 20 kg of zinc-loaded montmorillonite and mix them well to obtain an Intestinal mucosa repa...

Embodiment 3

[0046] preparation:

[0047] 1) Grinding the montmorillonite mineral to 300 mesh, adding water and stirring evenly to make a suspension slurry with a concentration of 8wt.%.

[0048] 2) Slowly add zinc chloride with a zinc content of 4% by weight of montmorillonite to the suspension slurry in step 1) under stirring, detect and adjust the pH value of the slurry to 5, react at room temperature for 7 hours, and detect the pH of the slurry Value, adjust with sodium hydroxide solution, make slurry pH value be 9.0;

[0049] 3) Select centrifugation or filtration to dehydrate the suspended slurry;

[0050] 4) Dry the filter cake obtained in step 3) at a temperature of 60° C., grind it to 300 mesh, and obtain 4 wt.% zinc-loaded montmorillonite with a content of zinc in the montmorillonite.

[0051] Take 0.8 kg of ellagic acid, 1 kg of L-carnitine, 2 kg of thymol, and 15 kg of zinc-loaded montmorillonite, mix them well, and then get a broiler intestinal mucosa repair agent (Intestina...

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PUM

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Abstract

The invention discloses a broiler intestinal mucosa repair agent, which is composed of: 0.5-1.0 parts by weight of ellagic acid, 0.5-1.5 parts by weight of L-carnitine compounds, 1-3 parts by weight of thymol, zinc-loaded montmorillonite 8 to 20 parts by weight. Compared with adding ellagic acid, L-carnitine compound, thymol or zinc-loaded montmorillonite to the feed alone, the broiler intestinal mucosa repair agent of the invention can significantly improve the intestinal morphology and intestinal barrier function of broiler chickens. The four components had significant interactions in repairing intestinal mucosa, improving mitochondrial function and increasing the level of mitophagy, and the four components had a positive synergistic combination effect. In addition, montmorillonite has a controlled-release effect on ellagic acid, L-carnitine compounds, and thymol, making it easy to mix with feed to form a uniform dispersion system and easy to use. Through the synergistic effect of each component, the present invention can significantly improve the mitochondrial autophagy level of broiler intestinal mucosa, protect mitochondrial function, and promote intestinal mucosal repair, thereby greatly improving intestinal morphology and barrier function.

Description

technical field [0001] The invention relates to a broiler intestinal mucosa repair agent. Background technique [0002] The intestine is responsible for connecting the body with the outside world in animals. On the one hand, the intestine has the functions of digestion, absorption of nutrients, immunity and endocrine. Substances entering the body cause damage to the body and play an important barrier function. In the modern poultry farming industry, improper feeding environment, choice of diet structure, the presence of infection sources and feed toxins in the feeding environment are all common factors affecting intestinal health. In addition, intestinal damage can lead to other diseases, which can negatively affect poultry growth and production. In recent years, people have paid more and more attention to the role of gut health in modern livestock and poultry farming. Maintaining the normal structure and function of the gut is critical to the growth and health of poultry...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K50/75A23K20/142A23K20/10A23K10/30A23K20/28
CPCA23K10/30A23K20/10A23K20/142A23K20/28A23K50/75
Inventor 胡彩虹王春春冯杰曹舒婷
Owner ZHEJIANG UNIV
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