A kind of porous polymer/collagen/graphene composite dressing and preparation method thereof

A graphene composite, graphene technology, applied in bandages, absorbent pads, medical science and other directions, can solve the problems of solvent pollution, complexity, etc., to reduce the risk of wound infection, improve breathability, and maintain the effect of the healing environment

Active Publication Date: 2021-07-09
重庆石墨烯研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of porous macromolecule / collagen / graphene composite dressing and preparation method thereof, and this dressing has good gas permeability, antibacterial property, absorbs exudate performance; Macromolecule matrix is ​​aqueous polymer emulsion, thus prepares The medium uses water as the solvent, does not contain organic solvents, and adopts the freeze-drying processing method, which has the characteristics of simplicity, convenience, environmental protection, and safety, and solves the problems of solvent pollution and complicated processes in the current artificial skin (dressing) preparation process

Method used

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  • A kind of porous polymer/collagen/graphene composite dressing and preparation method thereof
  • A kind of porous polymer/collagen/graphene composite dressing and preparation method thereof
  • A kind of porous polymer/collagen/graphene composite dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] The parts by weight of the raw materials used to prepare the porous composite wound dressing: 0.01 parts of graphene, 50 parts of polymer emulsion, and 20 parts of collagen.

[0029] The graphene is single-layer graphene oxide, the polymer emulsion is aqueous polyurethane emulsion, and the collagen is type I collagen.

[0030] The preparation method for preparing porous composite wound dressing comprises the following steps:

[0031] a. Emulsify the polymer emulsion for 30 minutes under the emulsifier to obtain a uniform emulsion;

[0032] b. ultrasonically disperse graphene in water, centrifuge and wash three times to obtain purified graphene, then add the purified graphene to 100ml of ionized water, and ultrasonically disperse at 25°C for 30 minutes to obtain a uniform graphene dispersion;

[0033] c. adding the graphene dispersion into the emulsified polymer emulsion, and stirring it ultrasonically for 60 minutes at 30° C. to obtain a uniformly dispersed graphene an...

Embodiment 2

[0037] Parts by weight of raw materials used to prepare porous composite wound dressings: 0.5 parts of graphene, 50 parts of polymer emulsion, and 40 parts of collagen.

[0038] The graphene is functionalized graphene, the polymer emulsion is polydimethylsiloxane emulsion, and the collagen is type II collagen.

[0039] The preparation method for preparing porous composite wound dressing comprises the following steps:

[0040] a. Emulsify the polymer emulsion for 30 minutes under the emulsifier to obtain a uniform emulsion;

[0041] b. ultrasonically disperse graphene in water, centrifuge and wash three times to obtain purified graphene, then add the purified graphene to 100ml of ionized water, and ultrasonically disperse at 35°C for 60 minutes to obtain a uniform graphene dispersion;

[0042] c. adding the graphene dispersion into the emulsified polymer emulsion, and stirring ultrasonically for 60 minutes at 20°C to obtain a uniformly dispersed graphene and polymer emulsion m...

Embodiment 3

[0046] Parts by weight of raw materials used to prepare porous composite wound dressings: 1 part of graphene, 80 parts of polymer emulsion, and 10 parts of collagen.

[0047]The graphene is graphene microspheres, the polymer emulsion is composed of polyacrylate emulsion and polyvinyl acetate emulsion, and the collagen is type IV collagen.

[0048] The preparation method for preparing porous composite wound dressing is the same as in Example 1.

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Abstract

A porous polymer / collagen / graphene composite dressing, comprising 20-90 parts of polymer emulsion, 0.01-2 parts of graphene, and 1-40 parts of collagen; the preparation method is as follows: a. emulsifying the polymer emulsion, graphite disperse the graphene into water; b. mix the graphene dispersion with the polymer emulsion; c. add collagen and stir evenly to obtain a uniformly dispersed polymer emulsion / collagen / graphene mixed dispersion; d. inject the dispersion into the mold In the mold, freeze at -20°C for 5h, and finally freeze-dry at -50°C and 10pa for 24h. The dressing prepared by the invention has good gas permeability, antibacterial property, and exudate absorption performance; in the preparation, water is used as a solvent without organic solvents, and a freeze-drying processing method is adopted, which has the characteristics of simplicity, convenience, environmental protection, and safety. At present, there are problems of solvent pollution and complicated process in the preparation process of artificial skin (dressing).

Description

technical field [0001] The invention relates to the field of material application, in particular to a porous polymer / collagen / graphene composite dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ on the human body and protects it from the invasion of pathogens. For a small area of ​​skin damage, the self-healing ability of the skin can well meet the needs. However, for large areas of skin damage (such as burns, diabetic feet, etc.), the self-healing ability of the skin cannot meet the needs. Due to the large area of ​​skin damage, it is accompanied by a large amount of body fluid loss and the wound is very easy to invade due to pathogens. These unfavorable factors seriously affect the healing of the wound and even threaten the life of the patient. Therefore, it is very important to prepare an artificial skin that has certain strength, toughness, absorbs exudate and maintains a moist wound healing environment, and has good...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/24A61L15/26A61L15/32A61L15/42A61L15/46
CPCA61L15/18A61L15/24A61L15/26A61L15/325A61L15/42A61L15/425A61L15/46C08L75/04C08L83/04C08L33/04C08L31/04
Inventor 夏和生罗高兴蹇志文王鹤王占华
Owner 重庆石墨烯研究院有限公司
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