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Method for measuring methyl p-hydroxybenzoate in drug based on vortex oscillation

A technology of methyl hydroxybenzoate and vortex oscillation, which is applied to measuring devices, instruments, scientific instruments, etc., can solve the problems of large errors in detection methods and low detection efficiency, and achieves elimination of influence, improvement of extraction effect, and reduction of detection. effect of error

Pending Publication Date: 2019-04-02
SHAOYANG UNIV
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Problems solved by technology

[0003] The existing detection methods have large errors and low detection efficiency, so a method based on vortex oscillation for the determination of methyl p-hydroxybenzoate in pharmaceuticals is now proposed

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  • Method for measuring methyl p-hydroxybenzoate in drug based on vortex oscillation
  • Method for measuring methyl p-hydroxybenzoate in drug based on vortex oscillation
  • Method for measuring methyl p-hydroxybenzoate in drug based on vortex oscillation

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Embodiment Construction

[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them.

[0027] refer to Figure 1-4 , a kind of method based on vortex oscillation determination methyl p-hydroxybenzoate in medicine, comprises the following steps:

[0028] S1: Sample preparation, the sample to be tested is crushed by an ultrasonic pulverizer, and the powder is magnetically screened;

[0029] S2: preparing an extractant, mixing n-hexane and ether according to a volume ratio of 1:9 to obtain an extractant;

[0030] S3: The sample is dissolved, and the sample powder after magnetic sieving is mixed and dissolved with methanol solution to obtain solution A;

[0031] S4: Vortex, put solution A and extractant into two test tubes respectively, pla...

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Abstract

The invention relates to the technical field of methyl p-hydroxybenzoate measurement, and discloses a method for measuring methyl p-hydroxybenzoate in a drug based on vortex oscillation. The method comprises the following steps of preparing a sample: grinding the sample which needs to be detected through an ultrasonic grinder, and carrying out magnetic sieving on powder; preparing an extracting agent: mixing n-hexane and diethyl ether according to a volume ratio of 1 : 9 to obtain the extracting agent; dissolving the sample: mixing and dissolving the sample powder subjected to the magnetic sieving and a methanol solution to obtain a solution A; carrying out vortex oscillation: putting the solution A and the extracting agent into two test tubes respectively, and placing the two test tubes on a vortex oscillator for carrying out vibration mixing; and carrying out filtering and separating: filtering the solution A subjected to the vortex oscillation to obtain filter residues and filtrate.According to the method, the extraction effect can be improved; the detection precision can be improved; the influence of metal impurities on a detection result can be eliminated; an extraction experiment does not need to be repeated; comparison of implementation results is facilitated; a detection error is reduced; and the working efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of methyl p-hydroxybenzoate determination, in particular to a method for determining methyl p-hydroxybenzoate in medicines based on vortex oscillation. Background technique [0002] Methyl p-hydroxybenzoate, also known as methylparaben or methylparaben, is a kind of preservative suitable for acidic systems, mainly used as a disinfectant and preservative for organic synthesis, food, cosmetics and medicine , is also used as a feed preservative. They have a good inhibitory effect on bacteria, mold and yeast, and have been widely used because of their low toxicity and non-irritating characteristics. But recent reports suggest that methylparaben can also cause contact dermatitis, and studies have linked methylparaben to breast cancer risk. The 2007 edition of the Hygienic Standard for Cosmetics in China stipulates that the maximum limit of a single ester of paraben preservatives in cosmetics is 0.4%. [0003] ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/14G01N27/48
CPCG01N27/48G01N30/02G01N30/06G01N30/14G01N2030/062
Inventor 粟雯
Owner SHAOYANG UNIV
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