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Fenugreek saponin enteric-coated micro-capsule preparation and preparation method thereof

A technology of fenugreek and saponin sausage, which is applied in the field of preparation of animal medicines, can solve the problems of restricting the application of animal disease prevention and treatment, gastric mucosal irritation, and easily irritating stomach, so as to improve drug safety and utilization rate, to avoid the effect of strong stimulation

Inactive Publication Date: 2019-03-29
GUANGZHOU LEADER BIO TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Fenugreek saponins are easily soluble in water. If they are administered directly through a large amount of mixing materials, the palatability is poor, the taste is bitter, and it is easy to irritate the stomach, and it is irritating to the gastric mucosa, which is easy to cause anorexia in animals, which seriously restricts its use in animal diseases. preventive and therapeutic applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Follow the steps below to prepare fenugreek saponin enteric-coated microcapsules:

[0027] S1. Weigh 1500g of gelatin, add 7 times the amount of purified water in parts by mass, heat to 45°C, and stir evenly to obtain mixture A;

[0028] S2. Add 500 g of Trigonelline extract dry powder (its saponin content is 80%) to mixture A, and stir evenly at 45° C. to obtain mixture B;

[0029] S3. Add purified water with 18 times the weight of gelatin to mixture B, and use disodium hydrogen phosphate and citric acid to adjust the pH of mixture B to 6.5 to obtain mixture C;

[0030] S4. Add 3000 g of acrylic resin No. II to mixture C, and stir at 45°C to obtain mixture D;

[0031] S5. The mixture D is spray-dried, and cooled in a fluidized bed to form a powder, the temperature of the fluidized air is 30° C., and the linear velocity is 60 m / s;

[0032] S6. Sieve the powder obtained in step S4, and collect the powder with a particle size below 40 mesh.

Embodiment 2

[0034] Follow the steps below to prepare fenugreek saponin enteric-coated microcapsules:

[0035] S1. Weigh 2000g of gum arabic, add 3 times the amount of purified water in parts by mass, heat to 40°C, and stir evenly to obtain mixture A;

[0036] S2. Add 500 g of Trigonelline extract dry powder (its saponin content is 75%) to mixture A, and stir evenly at 40° C. to obtain mixture B;

[0037] S3. Add purified water 22 times the mass of gum arabic to mixture B, use disodium hydrogen phosphate and citric acid to adjust the pH of mixture B to 7.0, and obtain mixture C;

[0038] S4. Add 2000g of acrylic resin No. Ⅱ and 2000 g of acrylic resin No. Ⅲ to the mixture C, and stir at 40°C to obtain a mixture D;

[0039] S5. The mixture D is spray-dried, and cooled in a fluidized bed to form a powder, the temperature of the fluidized air is 28° C., and the linear velocity is 65 m / s;

[0040] S6. Sieve the powder obtained in step S4, and collect the powder with a particle size below 40 ...

Embodiment 3

[0042] Follow the steps below to prepare fenugreek saponin enteric-coated microcapsules:

[0043] S1. Weigh 1000g of polyvinyl alcohol, add 7.5 times the amount of purified water according to the number of parts by mass, heat to 95°C, and stir evenly to obtain mixture A;

[0044] S2. Add 200 g of Trigonelline extract dry powder (its saponin content is 85%) to mixture A, and stir evenly at 90° C. to obtain mixture B;

[0045] S3. Add purified water of 17.5 times the mass of polyvinyl alcohol to mixture B, use disodium hydrogen phosphate and citric acid to adjust the pH of mixture B to 7.5, and obtain mixture C;

[0046] S4. Add 3000 g of acrylic resin No. III to mixture C, stir at 85° C. to obtain mixture D;

[0047] S5. The mixture D is spray-dried, and cooled in a fluidized bed to form a powder, the temperature of the fluidized air is 28° C., and the linear velocity is 65 m / s;

[0048] S6. Sieve the powder obtained in step S4, and collect the powder with a particle size bel...

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Abstract

The invention provides a fenugreek saponin enteric-coated micro-capsule preparation and a preparation method thereof. The fenugreek saponin enteric-coated micro-capsule preparation comprises the following components in percentages by mass: 1-10% of fenugreek saponin, 10-60% of a hydrophilic carrier, 1-10% of a pH regulator and 20-60% of an enteric-coated material. On the one hand, by the providedfenugreek saponin enteric-coated micro-capsule preparation, the bitter taste of the fenugreek saponin can be covered well, strong irrigation of the drug to the gastric mucosa of an animal is avoided,and the palatability is improved; and on the other hand, releasing of the drug in the intestinal tract is ensured, the bioavailability is increased, the times of administration are reduced, and the cost is saved.

Description

technical field [0001] The invention belongs to the technical field of preparation of animal medicines, and in particular relates to a trigonelline enteric-coated microcapsule preparation and a preparation method thereof. Background technique [0002] Trigonelline is a natural steroidal saponin widely found in many fenugreek plants. Studies have shown that fenugreek saponins have a wide range of pharmacological activities. A series of animal experiments have shown that fenugreek can inhibit the proliferation of various tumor cells and induce apoptosis, such as osteosarcoma, colon cancer, leukemia, liver cancer and breast cancer; fenugreek can prevent and treat diabetes and chronic diabetes. Complications, regulating blood sugar and blood lipids, etc.; Trigonela saponin can improve memory consolidation defects caused by sodium nitrite protein synthesis inhibitors, and also has the effect of resisting memory impairment caused by ethanol, indicating that Trigonela saponin has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/42A61K31/7048A61P3/00
CPCA61K9/5052A61K31/7048A61P3/00
Inventor 乔宽陶正国林劲冬程宗佳周应芳
Owner GUANGZHOU LEADER BIO TECH
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