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Method for reducing aromatic aldehyde into aromatic alcohol through selective catalysis of tetraethylammonium fluoride at low temperature

A technology of tetraethylammonium fluoride and aromatic aldehydes is applied in chemical instruments and methods, preparation of organic compounds, preparation of reduction of oxygen-containing functional groups, etc., and can solve problems such as poor selectivity, harsh reaction conditions, dangerous costs, etc. Mild, high-yield, safety-increasing effects

Pending Publication Date: 2019-03-26
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of effective preparation method of aromatic alcohol compound, and this method reaction condition is mild, and reaction speed is fast, and selectivity is high and very safe, to overcome prior art reaction condition is harsh, selectivity is poor, danger and high cost etc. defect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 48 mg of furfural to 2 mL of N,N-dimethylformamide, then add 10 mg of tetraethylammonium fluoride and 136 mg of polymethylhydrogensiloxane to seal the reaction in 50 mL of polyvinyl chloride plastic In the tube, react at 35 °C for 0.5 h to obtain furfuryl alcohol with a conversion rate of 94.9% and a yield of 92.3%.

Embodiment 2

[0023] Add 48 mg of furfural to 2 mL of N,N-dimethylformamide, then add 10 mg of tetraethylammonium fluoride and 68 mg of polymethylhydrogensiloxane to react in a closed 50 mL of polyvinyl chloride plastic In the tube, react at 35 °C for 0.5 h to obtain furfuryl alcohol with a conversion rate of 63.0% and a yield of 61.7%.

Embodiment 3

[0025] Add 48 mg of furfural to 2 mL of N,N-dimethylformamide, then add 10 mg of tetraethylammonium fluoride and 136 mg of polymethylhydrogensiloxane to seal the reaction in 50 mL of polyvinyl chloride plastic In the tube, furfuryl alcohol was reacted at 25 °C for 0.5 h, with a conversion rate of 85.4% and a yield of 81.9%.

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PUM

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Abstract

The invention discloses a mild, simple and convenient preparation method. The preparation method comprises the steps of mixing a reactant solution, silicon hydrogen and a catalyst, namely tetraethylammonium fluoride, putting the mixture into a sealed reaction container, and reacting at 25-60 DEG C for 0.5-2 hours, so as to obtain aromatic alcohol, wherein the use amount of silicon hydrogen is 2-4times of that of aromatic aldehyde, the concentration of aromatic aldehyde in the organic solvent is 2wt%-4wt%, and the content of the catalyst, namely tetraethylammonium fluoride relative to aromaticaldehyde is 5mol%-10mol%. According to the preparation method, the deficiencies of a traditional catalytic system that the dangerousness is high, the environment is polluted, the process is complex,and the content of byproducts is high can be effectively overcome.

Description

technical field [0001] The invention relates to a method for catalytically reducing aromatic aldehydes to aromatic alcohols by using tetraethylammonium fluoride as a catalyst, specifically using tetraethylammonium fluoride as a catalyst to catalyze the conversion of aromatic aldehydes under the condition that silicon hydrogen is used as a hydrogen donor For aromatic alcohol. Background technique [0002] Aromatic alcohol, as a compound with aroma, is widely used in the preparation of plant essential oils, perfumes, essential oils and other fragrance substances. Secondly, aromatic alcohol also plays a very important role in the synthesis of medicine as a kind of drug intermediate. Among them, the aromatic alcohol represented by furfuryl alcohol can also be used to produce furfural resin, furan resin and phenolic resin. [0003] The traditional preparation method of aromatic alcohol compounds uses the corresponding aromatic aldehydes as raw materials, and the catalytic syste...

Claims

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Application Information

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IPC IPC(8): C07D307/44C07C29/14C07C33/22C07C41/26C07C43/23C07D213/30C07D307/56
CPCC07C29/14C07C41/26C07D213/30C07D307/44C07D307/56
Inventor 李虎余钊卓杨松徐复生
Owner GUIZHOU UNIV
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