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Method of treating lower tract urothelial cancer

An epithelial and urethral technology, applied in the field of lower urinary tract urothelial carcinoma, which can solve problems such as toxicity, limited clinical utility, and local tolerance

Pending Publication Date: 2019-03-15
TARIS BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, intravesical (intravesical) delivery of high-dose gemcitabine can lead to significant systemic absorption and cause gastrointestinal, bladder, and bone marrow toxicity, further limiting clinical utility in addition to local tolerability issues

Method used

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  • Method of treating lower tract urothelial cancer
  • Method of treating lower tract urothelial cancer
  • Method of treating lower tract urothelial cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0256] Embodiment 1. A method of treating urothelial cancer of the lower urinary tract in an individual, comprising administering to the individual an effective amount of an antimetabolites, wherein the antimetabolites are locally delivered to the bladder.

Embodiment approach 2

[0257] Embodiment 2. A method of enhancing an immune response against urothelial cancer of the lower urinary tract in an individual, comprising administering to the individual an effective amount of an antimetabolites, wherein the antimetabolites are locally delivered to the bladder.

Embodiment approach 3

[0258] Embodiment 3. A method of reducing the recurrence or progression of urothelial cancer of the lower urinary tract in an individual, comprising administering to the individual an effective amount of an antimetabolites, wherein the antimetabolites are locally delivered to the bladder.

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Abstract

The present invention provides methods, devices, and kits related to treatment of urothelial carcinomas of the lower tract with antimetabolite (such as gemcitabine). In some aspects the methods, devices and kits relate to treatment of urothelial carcinomas of the lower tract with an antimetabolite (such as gemcitabine) and an immunomodulating agent.

Description

[0001] Cross references to related applications [0002] This application claims the rights and priority of U.S. Provisional Application 62 / 333,151 filed on May 6, 2016 and U.S. Provisional Application 62 / 443,614 filed on January 6, 2017. The content of each of these applications is incorporated herein by reference in its entirety. Background technique [0003] Bladder cancer is an important medical problem, and the currently available treatment options are unsatisfactory for many reasons. Generally, bladder cancer is classified as muscle invasive bladder cancer (MIBC) or non-muscle invasive bladder cancer (NMIBC). The pathological classification and staging of bladder cancer are as follows: pTa (urothelial involvement); pTis (high-risk urothelial limitation); pT1 (lamina propria invasion); pT2 (muscular invasion); pT3 (peribladder invasion); and pT4 (lengthening of pelvic organs). Bladder cancer can also be divided into grade 1 / 3 (well differentiated); grade 2 / 3 (moderately dif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61K9/00A61M31/00A61P13/10
CPCA61M31/00A61K31/7068A61K45/06A61P13/02A61P13/10A61P35/00A61P35/04A61K2300/00A61K9/00A61M2205/0216A61K9/0034A61M31/002
Inventor D·吉辛C·库蒂P·萨玛C·拉里沃-埃尔金斯C·瑟西V·阿加瓦尔
Owner TARIS BIOMEDICAL
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