Pelvic inflammation clearing granule for treating gynecological diseases and method for preparing pelvic inflammation clearing granule

A technology for gynecological diseases and penyanjing, which is used in the field of penyanjing granules for the treatment of gynecological diseases and its preparation field, can solve the problems of uneven content of active ingredients of medicinal materials, stability and quality controllability, affecting the treatment and rehabilitation of patients, etc. problems, to achieve the effect of stable clinical efficacy, accurate content of active ingredients, and clear ingredients

Inactive Publication Date: 2019-03-12
KUNMING JIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Penyanjing is a good medicine for gynecological treatment of pelvic inflammatory disease, but its shortcomings are also obvious. Due to the large number of medicinal materials in the prescription, the ingredients contained are complex. Among them, there are active ingredients with clear curative effects, and ingredients with unclear curative effects. Adverse ingredients of toxic and side effects. The collection of adverse reactions of Penyanjing in recent years shows that after use of Penyanjing, nausea, diarrhea, itching, rash, vomiting, headache and other adverse reactions will occur, which will affect the treatment and rehabilitation of patients; In addition, the content of active ingredients in medicinal materials is not uniform, resulting in differences in the content of active ingredients between batches, which seriously affects the stability of the curative effect, and also brings great problems to the stability of production and quality controllability

Method used

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  • Pelvic inflammation clearing granule for treating gynecological diseases and method for preparing pelvic inflammation clearing granule
  • Pelvic inflammation clearing granule for treating gynecological diseases and method for preparing pelvic inflammation clearing granule
  • Pelvic inflammation clearing granule for treating gynecological diseases and method for preparing pelvic inflammation clearing granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 9g of chlorogenic acid, 3g of catechin, 3g of protocatechuic acid, 3g of caffeic acid, 18g of stachydrine hydrochloride, 1g of motherwort hydrochloride, 4g of psyllidin, 53g of paeoniflorin, 3g of ligustrazine, ferulae Acid 3g, above-mentioned medicine mixes.

[0029] Add 100 g of starch and 200 g of sucrose to the above-mentioned main ingredient mixed, and mix well.

[0030] Use 2% to 10% of the weight of the main drug and auxiliary materials to make soft materials, use an extrusion granulator or a high-speed chopper to make wet granules, and dry the wet granules at a temperature below 80°C. Whole grains, packaged, and finished products after passing the test.

Embodiment 2

[0032] Weigh 8g of chlorogenic acid, 3g of catechin, 3g of protocatechuic acid, 4g of caffeic acid, 18g of stachydrine hydrochloride, 1g of motherurine hydrochloride, 4g of psyllidin, 53g of paeoniflorin, 3g of ligustrazine, ferulicum Acid 3g, above-mentioned medicine mixes.

[0033] Add 400 g of mannitol to the main ingredient mixed above, and mix well.

[0034] Use an appropriate amount of ethanol (75%) to make soft materials (the exact amount cannot be known, such as 3-5ml of ethanol or water added to each gram of mixed medicine), and use a high-speed chopper to make wet granules. The wet granules are then dried under reduced pressure below 70°C. The vacuum degree during the decompression drying is -50~-80kpa. The granules are sized, packaged, and the finished product is obtained after passing the test.

Embodiment 3

[0036] Weigh 8g of chlorogenic acid, 3g of catechin, 3g of protocatechuic acid, 3g of caffeic acid, 18g of stachydrine hydrochloride, 1g of motherurine hydrochloride, 4g of psyllidin, 54g of paeoniflorin, 3g of ligustrazine, ferulae Acid 3g, above-mentioned medicine mixes.

[0037] Add 50g of dextrin and 50g of xylitol to the main ingredient mixed above, and mix well.

[0038] Use 2% to 10% of the weight of the main drug and auxiliary materials to make soft materials, use an extrusion granulator or a high-speed chopper to make wet granules, and dry the wet granules at a temperature below 80°C. Whole grains, packaged, and finished products after passing the test.

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Abstract

The invention belongs to the technical field of pharmaceutical engineering, and particularly relates to a pelvic inflammation clearing granule for treating gynecological diseases and a method for preparing the pelvic inflammation clearing granule. The pelvic inflammation clearing granule comprises main medicines and excipients. A weight ratio of the main medicines to the excipients is 1:1-7; the main medicines comprise chlorogenic acid, theine, protocatechuic acid, caffeic acid, stachydrine hydrochloride, leonurine hydrochloride, plantamajoside, peoniflorin, ligustrazine and ferulic acid, andthe excipients are at least one type of starch, sucrose, mannitol, dextrin, xylitol and polyethylene glycol. The pelvic inflammation clearing granule and the method have the advantages that the pelvicinflammation clearing granule is in compatible prescription with effective components with definite curative effects, clear components and high safety, accordingly, effective components in granules prepared by the aid of the method are accurate in content, the granules are stable and uniform in quality, production is easy to control, stable clinical curative effects can be realized, and curativeeffects of products can be effectively guaranteed.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical engineering, and in particular relates to a Penyanjing granule for treating gynecological diseases and a preparation method thereof. Background technique [0002] Pelvic inflammatory disease is a common and frequently-occurring disease in gynecology, with an incidence rate as high as 30% to 60%. It is easy to turn into chronic pelvic inflammatory disease after a long time, seriously affecting women's body and mind and quality of life. This disease is mostly inflammatory changes of pelvic connective tissue caused by pathogen infection, and there is no specific treatment. At present, antibiotic-based therapy is mostly used. Recurrence or even progressive aggravation occurs when the immune function declines. The clinical treatment plan lacks specificity and the curative effect is not satisfactory. Although there are many Chinese medicines for the treatment of chronic pelvic inflammatory disea...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/216A61K31/4965A61K31/7048A61K31/40A61K31/235A61K31/7028A61K9/16A61K47/36A61K47/26A61P15/00
CPCA61K9/1623A61K9/1652A61K31/192A61K31/216A61K31/235A61K31/40A61K31/4965A61K31/7028A61K31/7048A61P15/00A61K2300/00
Inventor 普俊学李家伟罗燕芸
Owner KUNMING JIDA PHARMA
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