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Living body in-situ study platform for tissue regeneration inducing mechanisms, and application method thereof

A tissue regeneration, living technology, applied in biochemical equipment and methods, diagnosis and application using light, etc., can solve the problems of non-transparent skin, difficult pathological conditions, and large damage to experimental animals, so as to avoid transplantation experiments. the effect of failure

Active Publication Date: 2019-03-08
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since bones belong to the internal structure of the body, if you want to continuously observe its internal conditions, you need to cut the skin of the experimental site, which will cause great harm to the experimental animals
The skin is not transparent, making it difficult to observe the internal pathology of the skin tissue

Method used

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  • Living body in-situ study platform for tissue regeneration inducing mechanisms, and application method thereof
  • Living body in-situ study platform for tissue regeneration inducing mechanisms, and application method thereof
  • Living body in-situ study platform for tissue regeneration inducing mechanisms, and application method thereof

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Embodiment Construction

[0027] Embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary and not intended to limit the scope of the invention and its application.

[0028] refer to Figure 1 to Figure 6 , in one embodiment, a platform for studying the mechanism of induced tissue regeneration in vivo, including a living rat cornea, which has a region from which corneal epithelial cells 1 have been removed, and a large number of cells in the region The rat corneal stroma layer has a rat corneal stroma graft 5 and a rat corneal stroma graft bed 4 that are separated on the surface but still connected by sectioning from the set incision to the inside, and the tissue to be studied The engineering material 6 is placed in the cavity formed between the rat corneal stroma graft 5 and the separation surface 3 of the rat corneal stroma implant bed 4, the rat corneal stroma graft 5 and the rat corneal stroma graft 5 The rat c...

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Abstract

Disclosed are a living body in-situ study platform for tissue regeneration inducing mechanisms, and an application method thereof. The platform comprises a living rat cornea having a region from whichthe corneal epithelial cells are removed. A rat corneal stroma layer in the region has a rat corneal stroma layer graft and a rat corneal stroma layer planting bed, which are still connected after surface separation is formed by slicing from a set slit to the inner side. A to-be-studied tissue engineering material is put in a cavity formed between separation surfaces of the rat corneal stroma layer graft and the rat corneal stroma layer planting bed. The rat corneal stroma layer graft and the rat corneal stroma layer implanted bed are connected by a connecting material at the slit. The platform has the advantages that the interaction between the tissue engineering material and an organism can be well observed and evaluated through in-vivo microscope observation, tissue section observationand molecular biological analysis.

Description

technical field [0001] The invention relates to the field of tissue engineering, in particular to a platform for studying the mechanism of inducing tissue regeneration in vivo and a method for using the same. Background technique [0002] Corneal disease is the second most reversible and blinding eye disease after cataract in my country and even in the world, and corneal transplantation is the only reliable and effective way to restore eyesight clinically. At present, there is a serious shortage of corneal donors in my country. Although corneal transplantation is widely accepted all over the world, the specific regeneration mechanism is still unclear. The development of tissue-engineered cornea and the research on the mechanism of corneal regeneration and repair are urgent problems in today's society. [0003] Rats are a good choice of experimental animals due to their fast growth cycle, easy feeding, and clear genetic background. Rat cornea is a suitable platform for in si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50A61B3/107A61B5/00A61B3/10C12Q1/6888
CPCA61B3/1005A61B3/107A61B5/0059C12Q1/6888C12Q2600/158G01N33/5005
Inventor 弥胜利陈赟
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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