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Hydroxy asiaticoside liposome as well as preparation method and application thereof

A technology of madecassoside and oxaloside lipid, applied in the field of cosmeceuticals, can solve the problems of sensitive skin, thinning of the stratum corneum, high requirements of aromatherapists, etc., to promote the regeneration of fibroblasts, increase skin elasticity, Avoid overproliferative effects

Active Publication Date: 2019-03-08
广州市晨茜化工有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Common methods to eliminate stretch marks include: ① skin peeling method: using chemical peeling agents, which is easy to cause adverse reactions, resulting in thinning of the stratum corneum and skin sensitivity; The requirements are high, and the effect is not obvious; ③Laser therapy: this method is not suitable for large-scale treatment, and it is easy to cause skin sensitivity; ④Abrasion method: the physical grinding process of the skin is painful and easily causes skin damage
[0004] The currently marketed anti-pregnancy products have a single effect and cannot work synergistically with multiple effects, and it is difficult to reach the dermis of the skin, which affects the effect of use
Although madecassoside has the effects of scar repair, antibacterial, anti-inflammation, and promotion of fibroblast regeneration, it is difficult to penetrate the skin due to its polar macromolecules, and the external treatment effect is poor

Method used

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  • Hydroxy asiaticoside liposome as well as preparation method and application thereof
  • Hydroxy asiaticoside liposome as well as preparation method and application thereof
  • Hydroxy asiaticoside liposome as well as preparation method and application thereof

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preparation example Construction

[0031] The present invention provides a preparation method of the above-mentioned madecassoside liposome, comprising the following steps:

[0032] (1) Prepare the oil phase: melt phospholipids, cholesterol, and ceramide in a water bath at a temperature of 65 to 80°C, then add antioxidants and mix evenly, and set aside;

[0033] (2) Prepare the water phase: add madecassoside, polyalcohol, and collagen into the purified water of the formula, stir and heat at 65-80°C to dissolve madecassoside, collagen, and polyalcohol, and set aside;

[0034] (3) Preparation of colostrum: add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2) and stir continuously, and then emulsify at 10,000 rpm for 2 minutes at high speed to obtain colostrum;

[0035] (4) Preparation of liposomes: heat the colostrum prepared in step (3) at 70°C, and then process it through high-pressure homogenization equipment. 50°C;

[0036](5) Add plant essential oil, fibroblast growth fac...

Embodiment 1

[0040] (1) Prepare the oil phase: melt 3.0% soybean lecithin, 0.5% cholesterol, and 0.05% ceramide I in a water bath at a temperature of 65-80°C, then add 2.0% α-tocopherol and mix evenly, and set aside;

[0041] (2) Prepare the water phase: add 0.1% madecassoside, 10.0% propylene glycol, 0.2% deep-sea cod skin collagen, and 0.3% coconut collagen to 82.25% purified water, stir and heat at 65-80°C to dissolve ,spare;

[0042] (3) Preparation of colostrum: add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2) and stir continuously, and then emulsify at 10,000 rpm for 2 minutes at high speed to obtain colostrum;

[0043] (4) Preparation of liposomes: heat the colostrum prepared in step (3) at 70° C., and then process it through a high-pressure homogenization device with a pressure of 500 bar and a cycle of 3 times, and cool down to 50° C.;

[0044] (5) Add 0.4% rose essential oil, 0.1% shea oil, 0.1% fibroblast growth factor, and 1.0% honeysuckl...

Embodiment 2

[0046] (1) Prepare the oil phase: melt 1.0% phosphatidylcholine, 2.0% egg yolk lecithin, 5% cholesterol, and 0.1% ceramide II in a water bath at 65-80°C, then add 1.5% α-tocopherol and mix well ,spare;

[0047] (2) Preparation of water phase: 5% madecassoside, 10.0% propylene glycol, 5.0% 1,3-butanediol, 0.5% deep-sea cod skin collagen, 0.5% coconut collagen were added to 68.3% purified water , stir and heat at 65-80°C to dissolve, set aside;

[0048] (3) Preparation of colostrum: add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2) and stir continuously, and then emulsify at 10,000 rpm for 2 minutes at high speed to obtain colostrum;

[0049] (4) Preparation of liposomes: heat the colostrum prepared in step (3) at 70° C., and then process it through a high-pressure homogenization device with a pressure of 1000 bar and a cycle number of 2 times, and cool down to 50° C.;

[0050] (5) Add 0.1% carrot seed oil, 0.5% olive oil, and 0.1% fibrobl...

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Abstract

The invention relates to a hydroxy asiaticoside liposome as well as a preparation method and application thereof. The hydroxy asiaticoside liposome is prepared from 0.1 to 8.0 percent of hydroxy asiaticoside, 3.0 to 10.0 percent of phospholipid, 0.5 to 5.0 percent of cholesterol, 0.05 to 1.0 percent of ceramide, 0.5 to 2.0 percent of plant essential oil, 10.0 to 25.0 percent of polyhydric alcohols, 0.5 to 2.0 percent of antioxidants, 0.5 to 5.0 percent of collagen, 0.1 to 1.0 percent of mechanocyte growth factors, 0.5 to 2.0 percent of honeysuckle flower extracts and the balance of water in percentage by mass. The prepared hydroxy asiaticoside liposome can promote the seepage of the hydroxy asiaticoside into the skin to achieve the long-acting effect; all ingredients can achieve the cooperated effects of promoting the mechanocyte regeneration, conditioning the skin, increasing the skin elasticity and moisture, clearing away free radicals, supplementing the collagen, achieving the cellregeneration, enhancing the skin elasticity and eliminating striae gravidarum.

Description

technical field [0001] The invention belongs to the technical field of cosmeceuticals, and in particular relates to a madecassoside liposome and a preparation method and application thereof. Background technique [0002] The formation of stretch marks is mainly due to the influence of hormones during pregnancy. The swelling of the abdomen causes the elastic fibers and collagen fibers of the skin to be damaged or broken to varying degrees due to external force. The skin becomes thinner and thinner, and the abdominal wall skin appears different in width and length. Stretch marks are usually pink or purple wavy streaks; after childbirth, these streaks will gradually disappear, leaving white or silvery white shiny scar lines, that is stretch marks. [0003] Common methods to eliminate stretch marks include: ① skin peeling method: using chemical peeling agents, which is easy to cause adverse reactions, resulting in thinning of the stratum corneum and skin sensitivity; The requir...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/34A61K8/42A61K8/55A61K8/63A61K8/64A61K8/65A61K8/92A61K8/9789A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/14A61K8/345A61K8/42A61K8/553A61K8/63A61K8/64A61K8/65A61K8/922A61Q19/00A61Q19/02A61Q19/08A61K8/9789
Inventor 胡克
Owner 广州市晨茜化工有限公司
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