A kind of tranexamic acid flexible liposome for whitening and removing freckles and its preparation method and application
A flexible liposome, whitening and freckle-removing technology, applied in the directions of liposome delivery, peptide/protein ingredients, preparations for skin care, etc., can solve the problems of low bioavailability of tranexamic acid, inconvenient use, gastrointestinal irritation, etc. , to achieve the effect of promoting cell metabolism and cell regeneration, preventing skin aging, and lightening scars
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[0029] The present invention provides a method for preparing the above-mentioned tranexamic acid flexible liposome, comprising the following steps:
[0030] (1) prepare oil phase: phospholipid, cholesterol, membrane softener, ceramide, emollient are melted at 65~80 ℃ of water bath temperature, for subsequent use;
[0031] (2) Preparation of water phase: add tranexamic acid and polyol to the purified water in the formula amount, stir and heat at 65-80° C. to dissolve tranexamic acid and polyol, add antioxidant and mix evenly, for later use;
[0032] (3) Preparation of colostrum: dropwise add the oil phase prepared in step (1) to the water phase prepared in step (2) and keep stirring, then 8000-15000 r / min, high-speed shearing and emulsification for 5-15 minutes, and the get colostrum;
[0033] (4) Preparation of liposomes: the colostrum prepared in step (3) is kept at 70° C., and then processed by high-pressure homogenization or high-pressure micro-jet, the pressure is 500-120...
Embodiment 1
[0037] (1) Preparation of oil phase: 1.0% soybean lecithin, 0.5% cholesterol, 0.05% sodium cholate, 0.05% ceramide, 0.5% shea butter, 1.0% rosehip oil, 0.5% jojoba oil at 65~80℃ The temperature of the water bath is melted, mixed evenly, and ready for use;
[0038] (2) Preparation of water phase: add 0.1% tranexamic acid, 5.0% 1,3-butanediol, 0.5% vitamin C phosphate magnesium, 0.5% vitamin C ethyl ether to 90.3% purified water, stir and heat 65 ~ 80 ℃ to dissolve, for use;
[0039](3) Preparation of colostrum: the oil phase prepared in step (1) is added dropwise to the water phase prepared in step (2) and continuously stirred, and then 8000 r / min, high-speed shearing and emulsification for 5 min, to obtain colostrum;
[0040] (4) Preparation of liposomes: the colostrum prepared in step (3) is incubated at 70°C, and then processed by high-pressure homogenization equipment, the pressure is 500bar, the number of cycles is 3, and the temperature is lowered to 20~30°C, That is, t...
Embodiment 2
[0042] (1) Preparation of oil phase: 2.0% egg yolk lecithin, 0.5% cholesterol, 0.2% sodium deoxycholate, 0.1% ceramide, 1.0% rosehip oil, 1.0% olive oil were melted at a temperature of 65-80°C in a water bath, Mix well, set aside;
[0043] (2) Preparation of water phase: add 0.5% tranexamic acid, 7.0% glycerol, 0.5% vitamin C ethyl ether to 87.2% purified water, stir and heat at 65-80°C to dissolve, for later use;
[0044] (3) Preparation of colostrum: the oil phase prepared in step (1) is added dropwise to the water phase prepared in step (2) and continuously stirred, and then 10000r / min, high-speed shearing and emulsification for 5min, to obtain colostrum;
[0045] (4) Preparation of liposomes: the colostrum prepared in step (3) was incubated at 70°C, then processed by high-pressure homogenization equipment, the pressure was 800bar, the number of cycles was 3, and the temperature was lowered to 20-30°C, That is, tranexamic acid flexible liposomes are obtained. The tranexam...
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