Degradable and foldable biological amnion composite repair stent

Abstract

The invention discloses a degradable and foldable biological amnion composite repair stent. The degradable and foldable biological amnion composite repair stent comprises a tube-shaped body with an axially extending through hole, an elastic balloon is arranged at the front end of the tube-shaped body, a one-way valve is connected to the tail end of the tube-shaped body, the one-way valve closes the through hole at the position, a foldable net-pipe-shaped polylactic acid bracket covers the outer surface of the elastic balloon, a biological amnion covers the outer surface of the foldable net-pipe-shaped polylactic acid bracket, a plurality of tiny holes are formed in net filaments of the foldable net-pipe-shaped polylactic acid bracket, and biological amnion powder fills the plurality of tiny holes; under the initial state, the elastic balloon, the foldable net-pipe-shaped polylactic acid bracket and the biological amnion are compressed to in the compact state; and under the use state, after the stent is implanted into the body and swelling occurs due to pressurizing, the tube-shaped or waterdrop-similar-shaped state can be formed complying with the lacrimal duct / uterine cavity, or the other spatial states adaptive to body cavity also can be formed.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a multipurpose and degradable foldable bio-amniotic membrane composite repair bracket. Background technique [0002] Lacrimal duct obstruction diseases (LDOD) refer to a class of diseases caused by various reasons, characterized by lacrimal duct obstruction (lacrimal duct stenosis and / or occlusion) and epiphora as the main clinical manifestation. According to incomplete statistics, LDOD accounts for about 3% of ophthalmology outpatients, and is a common and frequently-occurring disease in ophthalmology. Lacrimal duct obstruction may occur in any part of the lacrimal duct, among which lacrimal canalicular obstruction is a relatively common type in LDOD, and its incidence rate accounts for about 16% to 25% of LDOD. There are many causes of canaliculus obstruction, including inflammation, trauma, congenital abnormalities, drugs, systemic diseases, iatrogenic injuries, and degen...

AI Technical Summary

Problems solved by technology

[0017] In summary, the current treatment of lacrimal duct obstruction, intrauterine adhesions and related diseases mainly has the following common problems: ①Simple non-surgical dredging treatment for lacrimal duct obstruction or intrauterine adhesions after intrauterine adhesion resection, due to lack of support The support effect of the substance on the wall of the lacrimal duct / uterine cavity, the closure of the lacrimal duct / uterine cavity wall, and the pathological repair of the wound will occur during the wound healing process, and granulation tissue or the lacrimal duct / uterine cavity wall will be formed later Scar contraction and adhesions are formed; ② non-degradable material stents, as foreign bodies, stimulate the lacrimal duct / uterine cavity mucosa, and even cause rejection in severe cases; ③ improper fixation of the stent after insertion into the lacrimal duct / uterine cavity causes slippage; ④ Implantation of stents will cause persistent expansion and compression of the tube wall, which is not conducive to the regression of inflammation and edema on the inner wall and the repair of the mucosa of the tube wall, hindering the normal repair of tissues, and can cause chronic inflammatory reactions on the wall of the lacrimal canaliculus / uterine cavity. In severe cases It can stimulate the mucosa to form granulation tissue and wrap the implanted stent, which will make it difficult to remove the stent and even cause secondary trauma; The active substance or drug enters the tissue to exert its effect

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