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Preparation method of colloidal suspension agent

A technology of colloidal suspensions and wetting agents, which is applied in the field of preparation of colloidal suspensions, can solve problems such as drug resistance, and achieve the effects of low toxicity, low volatility, and safe storage and transportation

Inactive Publication Date: 2019-02-26
JIANGSU NOON CROP SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to overcome the drug resistance problem of existing niclosamide ethanolamine salt, and provide a kind of suspension containing niclosamide ethanolamine salt and metaldehyde

Method used

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  • Preparation method of colloidal suspension agent
  • Preparation method of colloidal suspension agent

Examples

Experimental program
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Effect test

Embodiment 1

[0015] 30% niclosamide ethanolamine salt + 1% metaldehyde suspending agent in mass percentage, niclosamide ethanolamine salt 30%, metaldehyde 1%, alkylphenol polyoxyethylene ether 2%, polycarboxylate Naphthalene sodium salt 2%, sodium methylene bis-naphthalene sulfonate 3%, ethylene glycol 5%, benzoic acid 1%, organosilicone defoamer 0.5%, Cathone 0.2%, xanthan gum 0.2%, after Grind to 2-3um with a multi-stage sand mill to prepare 30% niclosamide ethanolamine salt + 1% metaldehyde SC.

Embodiment 2

[0017] 45% niclosamide ethanolamine salt + 1% metaldehyde suspending agent in mass percentage, niclosamide ethanolamine salt 45%, metaldehyde 1%, fatty alcohol polyoxyethylene ether 3%, polycarboxylic acid Sodium salt 2%, SOPA (Super) 2703%, Ethylene Glycol 5%, Benzoic Acid 1%, Organic Silicone Defoamer 0.5%, Cathone 0.2%, Xanthan Gum 0.1%, through multi-stage sand mill The grinding is qualified, and 45% niclosamide ethanolamine salt+1% metaldehyde SC is obtained.

Embodiment 3

[0019] 25% niclosamide ethanolamine salt + 1% metaldehyde suspending agent in mass percentage, niclosamide ethanolamine salt 25%, metaldehyde 1%, sodium lauryl sulfate 2%, methylene Sodium bis-naphthalene sulfonate 5%, calcium lignosulfonate 5%, ethylene glycol 5%, benzoic acid 0.3%, organic silicone defoamer 0.5%, Cathone 0.2%, xanthan gum 0.3%, deionized Water topped up to 100%. The components are uniformly mixed with a high-shear emulsifying disperser in this ratio, and ground to 2-3um by a multi-stage sand mill to prepare 25% niclosamide ethanolamine salt + 1% metaldehyde SC.

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Abstract

The invention belongs to the technical field of integrated prevention and treatment of epidemic situations of infectious diseases of schistosome, and particularly discloses a preparation method of a colloidal suspension agent. The colloidal suspension agent is prepared from niclosamide ethanolamine salt and metaldehyde which serve as active ingredients, supplemented by pesticidally acceptable auxiliary materials, wherein the auxiliary materials comprise 1 to 5 percent of a wetting agent, 1 to 20 percent of a dispersing agent, 1 to 10 percent of an antifreeze agent, 0.1 to 1 percent of a preservative, 0.1 to 1 percent of a pH regulator, 0.1 to 1 percent of a defoamer, 0.1 to 2 percent of a thickener and deionized water supplemented to 100 percent. The components are uniformly mixed and thenground to 1 to 10 um to obtain an aqueous suspension; and a mass ratio of the niclosamide ethanolamine salt to the metaldehyde is (1-50):(1-10). The colloidal suspension agent has a fine particle size, generally has a particle diameter of 2 to 5 um, has a high suspension rate, and is higher in pharmacological effect than wettable powder; and the colloidal suspension agent can be mixed with waterin any ratio, is convenient to use, and has obvious comprehensive and economic benefits.

Description

technical field [0001] The invention relates to the technical field of comprehensive prevention and control of schistosomiasis infectious diseases, in particular to a preparation method of a colloidal suspension. Background technique [0002] At present, niclosamide is the main molluscicide drug. It has no special smell, no irritation to the skin, low toxicity to humans and animals, and does not damage crops. It can be directly diluted with water for application. Moreover, the medicine has a large mollusc killing effect and a long-lasting effect. But the dissolubility and dispersibility of various powders of existing niclosamide are not ideal, not only the wetting time is long, and after diluting with water, the water surface changes from bright yellow to reddish brown soon. At the same time, flocculation occurs in the aggregation of drug particles, which not only pollutes the water surface, but also the active ingredients cannot be well dispersed evenly. The charge effect ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/24A01N37/40A01N25/04A01P9/00
CPCA01N43/24A01N25/04A01N37/40
Inventor 孟宪锋
Owner JIANGSU NOON CROP SCI CO LTD
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