Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Quality detection method for drug combination for treating cough, asthma and thoracic fullness

A quality inspection method and drug technology, applied in the field of pharmaceutical inventions, can solve problems such as decomposition of active ingredients, long heating and reflux time, blurred target spots, etc., and achieve the effects of reducing time cost, shortening drying time, and reducing heating time

Active Publication Date: 2019-02-22
贵州大隆药业有限责任公司
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the actual operation of this method, the test solution of the drug combination is prepared by this method and the heating and reflux time is long, which leads to the decomposition of the active ingredient, blurred target spots, and other problems, which affect the production of the drug combination. and quality inspection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quality detection method for drug combination for treating cough, asthma and thoracic fullness
  • Quality detection method for drug combination for treating cough, asthma and thoracic fullness
  • Quality detection method for drug combination for treating cough, asthma and thoracic fullness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 【Properties】This product is granules, the content is light brown granules; sweet, slightly astringent.

[0031] [Identification] Take 4g of the drug, grind it finely, add 15-25ml of ethyl acetate-ethanol at a ratio of 4:1 to dissolve, heat and reflux in a water bath for 30min, filter, and evaporate the filtrate in a water bath to exhaust the air. Negative pressure environment, add 1ml of ethyl acetate to the residue to dissolve, filter, and the filtrate is used as the test solution;

[0032] Take 1.3g of cotton root reference medicinal material and 1.5g of pine cone reference medicinal material respectively, add 30ml of water to each, boil for 25 minutes, filter, and shake the filtrate with 10ml of ethyl acetate-ethanol solution with a ratio of 4:1. Dehydrate the water with sodium sulfate, filter, evaporate the filtrate to dryness, and the environment of evaporation to dryness is a negative pressure environment of exhaust air, add 0.5ml of ethyl acetate to the residue t...

Embodiment 2

[0046]【Properties】This product is granules, the content is light brown granules; sweet, slightly astringent.

[0047] [Identification] Take 5g of the drug, grind it finely, add 15ml of ethyl acetate-ethanol at a ratio of 4:1 to dissolve, heat and reflux in a water bath for 35min, filter, and evaporate the filtrate to dryness in a water bath. Pressure environment, add 1ml of ethyl acetate to the residue to dissolve, filter, and the filtrate is used as the test solution;

[0048] Take 1.4g of cotton root reference medicinal material and 1.5g of pine cone reference medicinal material respectively, add 35ml of water to each, boil for 25 minutes, filter, and shake the filtrate with 10ml of ethyl acetate-ethanol solution with a ratio of 4:1. Dehydrate the water with sodium sulfate, filter, evaporate the filtrate to dryness, and the environment of evaporation to dryness is a negative pressure environment of exhaust air, add 0.5ml of ethyl acetate to the residue to dissolve, filter, a...

Embodiment 3

[0062] 【Properties】This product is granules, the content is light brown granules; sweet, slightly astringent.

[0063] [Identification] Take 6g of the drug, grind it finely, add 25ml of ethyl acetate-ethanol at a ratio of 4:1 to dissolve, heat and reflux in a water bath for 40min, filter, and evaporate the filtrate to dryness in a water bath. Pressure environment, add 1ml of ethyl acetate to the residue to dissolve, filter, and the filtrate is used as the test solution;

[0064] Take 1.7g of cotton root reference medicinal material and 2.5g of pine cone reference medicinal material respectively, add 50ml of water to each, boil for 40 minutes, filter, and shake the filtrate with 10ml of ethyl acetate-ethanol solution with a ratio of 4:1. Dehydrate the water with sodium sulfate, filter, evaporate the filtrate to dryness, and the environment of evaporation to dryness is a negative pressure environment of exhaust air, add 0.5ml of ethyl acetate to the residue to dissolve, filter, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
recovery rateaaaaaaaaaa
Login to View More

Abstract

The invention relates to a quality detection method for drug combination for treating cough, asthma and thoracic fullness. The drug combination is prepared from pinecones, cotton roots and folium eriobotryae. The quality detection method comprises the following steps: identifying active ingredients, namely pinecones, cotton roots and folium eriobotryae, and then determining residual quantity of free gossypol in cotton roots. Free gossypol is a polyphenol hydroxyl dinaphthalaldehyde compound, is a toxicant and is capable of resulting in human swelling and bleeding, nervous breakdown, inappetence, weight reduction and influence on fertility. According to the invention, the identification method is optimized on the basis of an original quality standard, and meanwhile, the identification for folium eriobotryae and the determination for the residual quantity of free gossypol in cotton roots are added, so that the quality monitoring for the drug combination for treating cough, asthma and thoracic fullness is greatly promoted. The quality detection method has high accuracy and high stability, can be used for effectively detecting the quality of the drug combination for treating cough, asthma and thoracic fullness and is capable of perfecting the quality standard.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a quality detection method for a combination of medicines for treating cough, dyspnea and chest fullness. Background technique [0002] This product is composed of pine cones, cotton roots, and loquat leaves; among them: pine cones have the effects of eliminating phlegm, relieving cough, relieving asthma, chronic bronchitis, asthma, and coughing with excessive phlegm. Cotton root has the functions of relieving cough, eliminating phlegm and relieving asthma, but a toxic substance free gossypol may remain in cotton root. Free gossypol is a polyphenolic hydroxyl bis-naphthaldehyde compound, which can cause redness, swelling, bleeding, nervous disorders, Loss of appetite, weight loss, affect fertility. Loquat leaves have the effects of clearing the lung and relieving cough, harmonizing the stomach and diuresis, and quenching thirst. It has the effect of treating phlegm cough due t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 刘念宁徐卫东黄庚
Owner 贵州大隆药业有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com