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Ratiometric fluorescent nanoprobe for visual detection of hypochlorite and its preparation and application

A technique for detecting hypochlorous acid and ratiometric fluorescence, which is applied in the field of ratiometric fluorescence nanoprobes, can solve problems such as detection application limitations, and achieve the effects of simple synthesis route, high sensitivity, and low cost investment

Active Publication Date: 2022-02-15
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the water environment in daily life is a neutral environment with a pH of about 7, which limits its detection application in the environment and daily life.

Method used

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  • Ratiometric fluorescent nanoprobe for visual detection of hypochlorite and its preparation and application
  • Ratiometric fluorescent nanoprobe for visual detection of hypochlorite and its preparation and application
  • Ratiometric fluorescent nanoprobe for visual detection of hypochlorite and its preparation and application

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Experimental program
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Effect test

Embodiment 1

[0040] Embodiment 1: The preparation method of the ratiometric fluorescent nanoprobe for visually detecting hypochlorite, the specific steps are as follows:

[0041] (1) Dissolve 4-(1,2,2-triphenylvinyl)acetophenone (0.267 mmol) and 5-nitrosalicylaldehyde (0.401 mmol) in 20 mL of acetonitrile, add a few drops of piperidine, placed in N 2 Under the conditions of protecting and avoiding light, reflux reaction for 12 hours, after the reaction was completed, 85~95% of the solvent was removed by rotary evaporation, the product was purified by column separation, and dried in vacuum to obtain product 1;

[0042] (2) The product 1 synthesized in step (1) was prepared as 0.02 mg / mL tetrahydrofuran (THF) solution A, and the polyethylene oxide-co-polystyrene prepared according to the patent CN201810983228.5 was prepared as 2 mg / mL 1 mL of tetrahydrofuran (THF) solution B, then take 1 mL of A and B and mix them respectively, add them into 10 mL of water under ultrasonic conditions, conti...

Embodiment 2

[0043] Embodiment 2: The preparation method of the ratiometric fluorescent nanoprobe for visually detecting hypochlorite, the specific steps are as follows:

[0044] (1) Dissolve 4-(1,2,2-triphenylethenyl)acetophenone (0.267 mmol) and 5-nitrosalicylaldehyde (0.267 mmol) in 10 mL of acetonitrile, add a few drops of piperidine, placed in N 2 Under the conditions of protecting and avoiding light, reflux reaction for 8 h, after the reaction was completed, 85~95% of the solvent was removed by rotary evaporation, the product was purified by column separation, and dried in vacuum to obtain product 1;

[0045] (2) The product 1 synthesized in step (1) was prepared as 0.02 mg / mL tetrahydrofuran (THF) solution A, and the polyethylene oxide-co-polystyrene prepared according to the patent CN201810983228.5 was prepared as 1.5 mg / mL 1 mL of tetrahydrofuran (THF) solution B, then take 1 mL of A and B and mix them respectively, add them into 10 mL of water under ultrasonic conditions, contin...

Embodiment 3

[0046] Embodiment 3: The preparation method of the ratiometric fluorescent nanoprobe for visual detection of hypochlorite, the specific steps are as follows:

[0047] (1) Dissolve 4-(1,2,2-triphenylethenyl)acetophenone (0.267 mmol) and 5-nitrosalicylaldehyde (0.534 mmol) in 30 mL of acetonitrile, add a few drops of piperidine, placed in N 2 Under the conditions of protecting and avoiding light, reflux reaction for 16 hours, after the reaction was completed, 85-95% of the solvent was removed by rotary evaporation, the product was purified by column separation, and dried in vacuum to obtain product 1;

[0048] (2) The product 1 synthesized in step (1) was prepared as 0.02 mg / mL tetrahydrofuran (THF) solution A, and the polyethylene oxide-co-polystyrene prepared according to the patent CN201810983228.5 was prepared as 2.5 mg / mL 1 mL of tetrahydrofuran (THF) solution B, then take 1 mL of A and B and mix them respectively, add them into 10 mL of water under ultrasonic conditions, ...

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Abstract

The invention discloses a ratio fluorescent nanoprobe for visually detecting hypochlorite and its preparation and application. The fluorescent nanoprobe is prepared from polyethylene oxide-co-polystyrene, 4-(1 , 2,2‑triphenylvinyl) acetophenone and 5‑nitrosalicylaldehyde as a new type of ratiometric fluorescent nanoprobe. The fluorescent nanoprobe can achieve high selectivity and high sensitivity rapid ratiometric detection of hypochlorite in pure aqueous solution. Compared with the existing fluorescence detection technology, the fluorescent nanoprobe obtained in the present invention has a high selectivity ratio, rapid response and visual detection of hypochlorite, can effectively avoid aggregation-induced fluorescence quenching, and has excellent biocompatibility It is suitable for large-scale synthesis and practical production applications, and has great application prospects in technical fields such as analytical chemistry, life sciences, and environmental sciences.

Description

technical field technical field [0001] The invention belongs to the technical field of preparation, analysis and detection of chemical materials, and in particular relates to a ratio fluorescent nanoprobe for visually detecting hypochlorite and its preparation and application. Background technique [0002] Hypochlorite is a very important reactive oxygen species that widely exists in biological cells and plays an important role in the process of oxidative stress in biological systems. However, because of its high activity, low content, and uneven distribution, It is particularly important to explore their functions in living organisms. In addition, hypochlorite is also widely used in the disinfection treatment of domestic water, such as tap water disinfection, swimming pool water disinfection, etc. The United Nations Health Organization pointed out that for the treatment of these domestic waters, the effective free chlorine concentration should not be less than 0.2 mg / L (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C201/12C09K11/06G01N21/64C07C205/45C07C45/74C07C49/835
CPCG01N21/64G01N21/6428G01N21/643G01N21/6456C09K11/06C07C45/74C07C49/835C07C201/12C07C205/45C09K2211/1007G01N2021/6421G01N2021/6439
Inventor 陈建王宏林众邹朝张培盛
Owner HUNAN UNIV OF SCI & TECH
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