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Buccal tablets capable of resisting dentin hypersensitivity and preparation method of buccal tablets

A tooth sensitivity and buccal tablet technology, which is applied in the field of buccal tablets and its preparation, can solve the problems of slow effect, short retention time of toothpaste, anti-dentin sensitivity compounds can not fully exert the anti-dentin sensitivity effect, and achieve good taste , quick effect

Inactive Publication Date: 2019-02-15
白昀易 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above patent documents, the anti-dentin hypersensitivity toothpaste has a relatively short retention time in the oral cavity, resulting in the anti-dentin hypersensitivity compound in the toothpaste not being able to fully exert the anti-dentin hypersensitivity effect, and the effect is very slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0041]The preparation method of the buccal tablet of the present invention comprises the following steps: (1) preparation of the first mixed powder; (2) preparation of the second mixed powder; (3) tabletting.

[0042] In step (1), the raw materials comprising potassium chloride, vitamin C, part of sugar alcohol, part of lactose and optional auxiliary materials are uniformly mixed and crushed to 30-70 mesh to obtain the first mixed powder; the part of sugar alcohol The quality of the part of lactose accounts for 30-60wt% of all sugar alcohols; the quality of said part of lactose accounts for 30-60wt% of the whole lactose;

[0043] The consumption of each component in the step (1) is as above, and will not be repeated here. Preferably, potassium chloride, vitamin C and auxiliary materials are firstly mixed uniformly to obtain a mixture; then the mixture is uniformly mixed with the part of sugar alcohol and part of lactose. Adopting the above-mentioned mixing method is conducive...

Embodiment 1

[0048] The formulation of the buccal tablet for anti-tooth hypersensitivity is as follows:

[0049] 8mg Potassium Chloride, 10mg Vitamin C, 400mg Xylitol, 75mg Lactose, 5mg Magnesium Stearate, 1mg Flavor.

[0050] The preparation method of above-mentioned buccal tablet is as follows:

[0051] (1) uniformly mix 8 mg of potassium chloride, 10 mg of vitamin C and 1 mg of essence to obtain a mixture; then uniformly mix the mixture with 200 mg of xylitol and 30 mg of lactose, and pulverize to 30-70 mesh to obtain the first mixed powder;

[0052] (2) Mix the first mixed powder, 200mg xylitol, 45mg lactose and 5mg magnesium stearate evenly to obtain the second mixed powder; the particle diameters of xylitol and lactose are both 20-50 mesh;

[0053] (3) Compress the second mixed powder into tablets with a pressure of 20kgf to obtain buccal tablets.

[0054] Refer to Table 3 for the oral test results of the buccal tablets.

Embodiment 2～5

[0056] Except that the formula quantity of potassium chloride is different, other conditions of embodiments 2-5 are respectively identical with embodiment 1. The formula quantity of the potassium chloride of embodiment 2~5 is referring to table 1. Refer to Table 3 for the oral test results of the buccal tablets of Examples 2-5.

[0057] The formula quantity of the potassium chloride of table 1 embodiment 2~5

[0058] serial number

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Abstract

The invention discloses buccal tablets capable of resisting dentin hypersensitivity and a preparation method of the buccal tablets. The buccal tablets are prepared from components as follows: 8-16 mgof potassium chloride, 5-30 mg of vitamin C, 340-550 mg of sugar alcohol, 50-95 mg of lactose and 3-8 mg of stearate. The multiple components of the buccal tablets have a synergistic effect of resisting dentin hypersensitivity, so that the buccal tablets can fully play the efficacy of resisting the dentin hypersensitivity, take effect more quickly and taste good.

Description

technical field [0001] The invention relates to a buccal tablet and a preparation method thereof, in particular to an anti-tooth hypersensitivity buccal tablet and a preparation method thereof. Background technique [0002] Tooth sensitivity is a common oral health problem. Tooth hypersensitivity, also known as dentin hypersensitivity, refers to the symptoms of tooth pain caused by exposed dentin being exposed to external stimuli such as temperature, chemistry, machinery, and osmotic pressure. There are many reasons for tooth hypersensitivity, including various pathological and physiological factors that cause loss of enamel or cementum, and exposure of dentin, such as abrasion, gingival recession, improper brushing methods, and excessive intake of acidic foods. [0003] There are many methods currently applied to dental hypersensitivity, such as: anti-allergic toothpaste, drug therapy, electronic desensitization, YAG laser desensitization, microwave treatment, etc. Many p...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/12A61K47/46A61K33/14A61P1/02A61P37/08A61K31/375A61K31/047A61K31/7016
CPCA61K9/0056A61K9/2013A61K9/2068A61K31/047A61K31/375A61K31/7016A61K33/14A61P1/02A61P37/08A61K2300/00
Inventor 白昀易
Owner 白昀易
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