Application of Lactobacillus rhamnosus in the preparation of a composition with the effect of inhibiting fatty liver disease

A technology of Lactobacillus rhamnosus and fatty liver, which is applied in the field of microbiology, can solve the problems that the efficacy of Lactobacillus rhamnosus colitis has not been reported, and achieve the effects of inhibiting liver function damage, improving microstructure, and promoting liver damage repair

Active Publication Date: 2022-05-20
NANCHANG UNIV
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Problems solved by technology

However, there is no report on the efficacy of Lactobacillus rhamnosus in alleviating colitis

Method used

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  • Application of Lactobacillus rhamnosus in the preparation of a composition with the effect of inhibiting fatty liver disease
  • Application of Lactobacillus rhamnosus in the preparation of a composition with the effect of inhibiting fatty liver disease
  • Application of Lactobacillus rhamnosus in the preparation of a composition with the effect of inhibiting fatty liver disease

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experiment example

[0014] Below in conjunction with accompanying drawing and experimental example, test data, the present invention is described in detail:

[0015] Healthy SD rats, male, weighing 120-150 g, were placed in a feeding environment for adaptation for 1 week. Rats were randomly divided into normal group (ND), high-fat model group (HFD), Lactobacillus rhamnosus CGMCC NO.15573 low-dose group (10 8 CFU / mL) and Lactobacillus rhamnosus CGMCC NO.15573 high-dose group (10 9 CFU / mL) 4 groups, 10 rats in each group. All rats drank water normally, and were given high-fat diets in the model group, high-dose group and low-dose group. According to 10mL / kg body weight, the high-dose group and the low-dose group were given the corresponding dose of Lactobacillus rhamnosus CGMCC NO.15573, and the high-fat model group and the normal group were given the same dose of normal saline, for 5 consecutive weeks. After the experiment, the rats were anesthetized by chloral hydrate, blood was collected by h...

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Abstract

The application of Lactobacillus rhamnosus in the preparation of a composition with the effect of inhibiting fatty liver lesions. The strain is Lactobacillus rhamnosus NCU2217, which has been preserved in China Microbiology Culture Collection Management Committee General Microorganisms on April 9, 2018 Center, address: No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences, which is referred to as CGMCC, and the preservation number is CGMCC NO.15573. The Lactobacillus rhamnosus used in the present invention is effective in regulating high-fat diet In the induced non-alcoholic fatty liver disease, it shows the effects of inhibiting liver function damage, reducing liver fat accumulation, improving the microstructure of fatty liver, and promoting the repair of liver damage.

Description

technical field [0001] The invention belongs to the field of microorganisms, and in particular relates to a strain of Lactobacillus rhamnosus capable of inhibiting fatty liver disease and its application. Background technique [0002] Lactobacillus rhamnosus is a probiotic lactic acid bacterium that has been widely studied abroad in recent years, and it widely exists in traditional fermented dairy products and the human gastrointestinal tract. A large amount of data have shown that Lactobacillus rhamnosus has broad development and application prospects in the field of probiotics. The current research results have confirmed that Lactobacillus rhamnosus has the following beneficial functions: (1) antibacterial effect. According to reports, Lactobacillus rhamnosus has inhibitory effects on some pathogenic bacteria in food and intestines, and the antibacterial substances produced by its fermentation have inhibitory effects on Gram-positive, negative bacteria and various pathoge...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A23L33/135A23C9/123A23C9/152C12R1/225A23L2/38
CPCA23C9/1234A23C9/152A23C9/16A23C19/061A23L2/382A23L19/20A23L33/135A23V2002/00C12R2001/225C12N1/205A23V2400/175A23V2200/32Y02A50/30
Inventor 熊涛谢明勇关倩倩黄涛
Owner NANCHANG UNIV
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