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Adsorbent for extracorporeal blood circulation to remove LDL, preparation method thereof, and perfusion device

An adsorbent and external circulation technology, which is applied to suction devices, chemical instruments and methods, other chemical processes, etc., can solve the problems of high metal ion adsorption rate, high antibody cost, low adsorption rate, etc. Specific adsorption, the effect of reducing dosage

Active Publication Date: 2019-01-22
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The DALI product (polyacrylic acid immobilized on the porous polyacrylamide carrier) of Fresenius Company in Germany has a problem of high adsorption rate of metal ions, resulting in Ca 2+ The loss is serious, and long-term treatment using this product requires supplementation of electrolytes (2001T.Bosch DirectAdsorption of Lipoproteins from Whole Blood by DALI), and the cost of this product is relatively high, it is only one-time use, and cannot be regenerated
The ligands of another type of commercial adsorbent are biologically derived antibodies, which are extremely expensive and difficult to store
Domestic DELP filters use membrane filtration to remove LDL. Compared with adsorption products, the filtration membrane has a low adsorption rate for target substances and poor safety.

Method used

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  • Adsorbent for extracorporeal blood circulation to remove LDL, preparation method thereof, and perfusion device
  • Adsorbent for extracorporeal blood circulation to remove LDL, preparation method thereof, and perfusion device
  • Adsorbent for extracorporeal blood circulation to remove LDL, preparation method thereof, and perfusion device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 20mL of polyacrylic acid carrier resin, use epichlorohydrin or 1,4-butanediol diglycidyl ether for epoxidation, control the pH at 8 to 11, and react at 30°C for 3 hours to obtain the epoxidized carrier , the epoxidized carrier was purified to neutral pH with purified water. Mix the epoxidized support with the aminating agent at a volume ratio of 1: (2 to 6), and react at 30°C for 1.5 hours to aminate the support. The aminating agent includes ammonia water, ethylenediamine, 1,2 - propylenediamine or 1,3-propylenediamine. The carrier was washed and purified to neutral pH using purified water. Mix the aminated carrier with polyacrylic acid and EEDQ at a mass ratio of 10:0.2:0.1, control the pH to 3 to 7, react at room temperature for 12 hours, immobilize the polyacrylic acid ligand on the carrier, and clean and purify the adsorbent. Obtain LDL adsorbent.

[0043] Using polyacrylic acid ligands with different molecular weights (2,000 to 450,000, that is, 2k to 45w),...

Embodiment 2

[0049] Two polyacrylic acid ligands with different molecular weights were mixed in proportion, and the adsorbent was synthesized by the method in Example 1. The adsorption rates of the obtained adsorbents for LDL and metal ions are shown in Table 2 below. The mass ratio in Table 2 refers to the mass ratio of the polyacrylic acid ligand with a molecular weight of 1 and the polyacrylic acid ligand with a molecular weight of 2 in the total mass of the ligand mixture.

[0050] Table 2 The proportion of polyacrylic acid ligand and the adsorption rate of its adsorbent

[0051]

[0052] By comparing Table 2 with Table 1, it can be seen that mixing polyacrylic acid with different molecular weights as a ligand can increase the adsorption rate of the adsorbent to LDL or maintain a high adsorption rate to LDL, while reducing the adsorption rate of the adsorbent. The adsorption rate of metal ions is even reduced by about 50%, which improves the safety of the use of the adsorbent. Thi...

Embodiment 3

[0077] The adsorbent prepared by mixing the acrylic ligands with molecular weights of 3k and 8w at a mass ratio of 4:6 in Example 2, that is, adsorbent 2, was pre-flushed with electrolyte in a static or dynamic manner. Preflushing can be performed in two ways, static or dynamic. Among them, the step of static preflushing includes adding 1mL to 10mL of electrolyte solution to 1mL of adsorbent, sucking out the electrolyte solution completely after shaking for 10 minutes, and performing static plasma experiment on the remaining adsorbent; dynamic preflushing includes putting 100mL of adsorbent into In a cylinder with a diameter of 5 cm, use more than 50 mL of electrolyte solution to pre-flush from bottom to top at a speed of 30 mL / min. After pre-flushing, take 1 mL of adsorbent for static plasma experiments. The composition of the electrolyte solution used is shown in Table 8 below.

[0078] Table 8 Electrolyte solution

[0079]

[0080] After using different electrolytes to...

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Abstract

The invention relates to an adsorbent for extracorporeal blood circulation to remove LDL, a preparation method thereof, and a perfusion device. The adsorbent is formed by introducing an amino group toa carrier and reacting the amino group with a polyanion; and the polyanion is at least one of polyacrylic acid, carbomer and dextran sulfate, wherein the polyacrylic acid is a polyacrylic acid havinga molecular weight of 5,000 to 450,000, or the polyacrylic acid is a mixture of at least two polyacrylic acids with different molecular weights; the carbomer is carbomer with a single grade, or the carbomer is a mixture of at least two carbomers with different grades; and the dextran sulfate is subjected to an hydroformylation reaction together with periodate prior before reacting with the aminogroup, and is subjected to a reduction reaction after reacting with the amino group. The adsorbent has a high adsorption rate and specific adsorption to the LDL.

Description

technical field [0001] The invention relates to the technical field of extracorporeal blood purification, in particular to an adsorbent that can be used to remove low-density lipoprotein and cholesterol in blood extracorporeal circulation, a preparation method and a treatment method before use. Background technique [0002] Lipid metabolism disorder is an important factor that causes atherosclerosis and subsequently cardiovascular and cerebrovascular diseases. Epidemiological investigations were confirmed. [0003] Active lipid-lowering therapy plays an important role in cardiovascular and cerebrovascular diseases. The vast majority of patients with lipid metabolism disorders can control the disease well through active diet control, appropriate physical activity and appropriate lipid-lowering drugs, but patients with congenital homozygous familial hypercholesterolemia need to be treated regularly. Lipid-lowering treatment, otherwise coronary heart disease will appear at an...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30
CPCB01J20/265C08G81/00C08G81/02A61M1/3679B01J2220/4812
Inventor 董凡张莉露李波
Owner JAFRON BIOMEDICAL
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