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A high-performance micro-mixer used in ultra-high performance liquid chromatography analyzer

A chromatographic analyzer and ultra-high-efficiency liquid phase technology, applied in the field of micro-mixers, can solve the problems of high cost and unstable mixing performance of micro-mixers, and achieve the effects of prolonging the working life, prolonging the molecular diffusion time, and enhancing the convection effect

Active Publication Date: 2021-06-04
BEIJING UNIV OF TECH +1
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention mainly aims at the instable mixing performance and high cost of micro-mixers in UPLC, and provides a new type of UPLC micro-mixer with simple structure, high mixing efficiency and stable performance. The micro-mixer can be applied to existing In some ultra-high performance liquid chromatography analyzers, improve the accuracy of drug analysis and environmental monitoring

Method used

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  • A high-performance micro-mixer used in ultra-high performance liquid chromatography analyzer
  • A high-performance micro-mixer used in ultra-high performance liquid chromatography analyzer
  • A high-performance micro-mixer used in ultra-high performance liquid chromatography analyzer

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Embodiment Construction

[0026] Since the present invention is based on a micro-scale mixer, the requirements for processing methods are relatively high, and the present invention needs to work in a high-pressure environment, and the traditional micro-mixer manufacturing process cannot meet the requirements of the present invention. Based on the above considerations, A high-performance micro-mixer used in ultra-high performance liquid chromatography analyzers of the present invention is processed and manufactured using the additive manufacturing technology of laser metal powder sintering and 3D printing.

[0027] Two different solvents flow into the mixing chamber at equal speed from the two inlet channels respectively, and complete the mixing while flowing in a square wave path in the mixing chamber, and finally the mixed solvent flows out from the outlet channel on the right to complete the mixing.

[0028] The two solvents are fully mixed in the mixing chamber by means of molecular diffusion and con...

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Abstract

The invention discloses a high-performance micro-mixer used in an ultra-high performance liquid chromatography analyzer, which belongs to the field of fluid micro-mixing in high-end biochemical analysis and micro-total analysis systems and related fields. The micro-mixer includes two inlet channels, a mixing chamber, twelve baffles staggered up and down, and an outlet channel; the existence of baffles enhances the convection effect of solvent flow, and is easy to form a vortex area. In addition, the baffles staggered The plate makes the mixed solvent flow in a square wave path in the mixing chamber, and vortices are also easy to form at the corners. The existence of the vortex can break the laminar flow state of the solvent flow and prolong the diffusion path of the mixed solvent in the mixing chamber, which significantly enhances micro The mixing performance of the mixer further improves the precision of the ultra-high performance liquid chromatography analyzer.

Description

technical field [0001] The invention relates to a micro-mixer in an ultra-high performance liquid chromatography analyzer, which has higher mixing performance. The invention belongs to the field of fluid micro-mixing in high-end biochemical analysis and micro-total analysis systems. Background technique [0002] Ultra-high performance liquid chromatography (UPLC) is an important means to solve problems such as drug analysis, biochemical analysis, blood testing and environmental testing, and plays an important role in improving drug treatment capabilities and enhancing disease analysis capabilities. The instrument is rapidly used in food safety, environment, pharmaceuticals, scientific research and other fields. Despite the rapid development of ultra-high performance liquid chromatography, the high-precision reagent delivery system in it lacks a matching supplier and a complete supply chain solution, and its flow accuracy, accuracy, pressure pulsation and system delay volume...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F5/06B01F13/00G01N30/02
CPCG01N30/02B01F25/421B01F33/305
Inventor 刘赵淼赵晟王文凯逄燕殷参徐迎丽
Owner BEIJING UNIV OF TECH
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