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Glacier water composite extracts of gentian, emblica and mecongella and their preparation method and application

A compound extract and technology of Meconopsis, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of not extracting Meconopsis gentianus, not preparing external skin preparations, etc. problems, to achieve good effect of scavenging free radicals, optimize extraction effect, and simple preparation process

Active Publication Date: 2022-07-22
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no reports about extracting gentian, emblica, and Meconopsis five veins from glacier water, nor are there reports on using the compound extracts of these three plants or the compound extracts of glacier water to prepare external skin preparations

Method used

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  • Glacier water composite extracts of gentian, emblica and mecongella and their preparation method and application
  • Glacier water composite extracts of gentian, emblica and mecongella and their preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The gentian (whole herb), the emblica (fruit) and the Meconopsis (whole herb) with a water content of less than 5% were respectively crushed and passed through an 80-mesh sieve.

[0033] Take 10 g of the crushed medicinal raw materials and mix, add 600 mL of glacier water, immerse and stir at room temperature for extraction, and the stirring speed is 400 rpm to obtain an extract. The extraction time was 10, 20, 30, 40, and 50 min, respectively. Centrifuge and remove the supernatant.

[0034] The glacier water is taken from the Dorje Teng Nima Spring (5128 meters above sea level) in the Himalayas. The deuterium content in the glacier water is 134ppm, pH=7.4, no bromate, and contains the following components: Sr 2+ 0.2~0.5mg / L, K+ 0.5~10.0mg / L, Na + 1.0~5.0mg / L, Ca 2+ 14.0~30.0mg / L and Mg 2+ 2.0 to 10.0 mg / L; and the glacier water does not contain insoluble solids or suspended solids, and the total dissolved solid content therein is 80 to 100 mg / L.

[0035] In additi...

Embodiment 2

[0040] Example 2 Total flavonoid leaching rate

[0041] with Al(NO 3 ) 3 -NaNO 2 The leaching rate of total flavonoids was calculated by -NaOH method, and quercetin was used as the standard for detection.

[0042] Preparation of standard curve: add 50 μL of 5% NaNO to 300 μL of quercetin standard solutions of different concentrations respectively 2 solution, mixed and placed at room temperature for 6 min, and then added 50 μL of 10% Al (NO 3 ) 3 The solution was mixed and placed at room temperature for 6 minutes, then 400 μL of 4% NaOH solution and 100 μL of distilled water were added. After mixing, the solution was placed at room temperature for 15 minutes. The quercetin standard solution of the same concentration was made into 3 copies in parallel, and the OD value at 500 nm was measured. Mean OD of Quercetin Standard Solution 500 value as a standard curve.

[0043] Preparation and detection of sample solution to be tested: take 300 μL of sample solution, add 50 μL of...

Embodiment 3

[0049] Example 3 Total polyphenol leaching rate

[0050] The total polyphenol leaching rate was calculated by the Folin-Ciocalteu method, and gallic acid was used as the standard for detection.

[0051] Preparation of standard curve: Add 0.5mL of 10% Folin-Ciocalteu reagent to 0.1mL of gallic acid standard solution of different concentrations, mix, and then add 0.4mL of 7.5% Na after standing at room temperature for 5min 2 CO 3 The solution was mixed and placed at room temperature for 60min. The gallic acid standard solution of the same concentration was made in parallel in 3 copies, and the OD value at 765 nm was measured, and the average OD of the gallic acid standard solution of each concentration was used. 765 value as a standard curve.

[0052] Preparation and detection of the sample solution to be tested: take 0.1 mL of the sample solution obtained in Example 1, add 0.5 mL of 10% Folin-Ciocalteu reagent, mix, and leave it at room temperature for 5 minutes before adding...

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Abstract

The invention belongs to the field of plant extraction and the field of daily chemicals, and in particular relates to a glacier water composite extract of gentian, Emblica and Elephant wormwood, and a preparation method is: Mixed extraction; composite extract contains total flavonoids, total polyphenols and total iridoids. Using glacier water for extraction, the extraction effect is significantly improved, the process is simple, the obtained compound extract can effectively scavenge free radicals, has anti-aging effect, and can be used in the preparation of external skin preparations, especially in the preparation of free radical scavenging and anti-aging skin topical preparations.

Description

technical field [0001] The invention relates to the field of plant extracts and the field of daily chemicals, and in particular relates to a glacier water composite extract of gentian, emblica radix and meccanthus gracilis, a preparation method and an application. Background technique [0002] There are about 400 species of Gentiana, most of which are distributed in the northern temperate zone. There are 247 species in my country, all over the country, most species are concentrated in the southwestern mountainous areas, mainly growing in alpine rocky beaches, alpine meadows and shrubs. Known for their blue flowers, gentian is the most prized type of wild flower. According to the "Chinese Pharmacopoeia", there are four kinds of gentian plants, namely gentian (G.scabra), gentian (G. rigescens), its dried roots and rhizomes can clear away heat and dampness, and purge liver and gallbladder fire. Studies have shown that gentian extract has liver protection, stomach, gallbladde...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61Q19/08
CPCA61Q19/08A61K8/97A61K2800/805
Inventor 章漳蒋耀权李俊河野善行
Owner JALA GROUP CORPORATION
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