Amino sugar modified antibacterial gold nanoparticle and preparation method thereof, and applications

A gold nanoparticle and nanoparticle technology, applied in the field of nanomaterials, can solve the problems of bacterial overgrowth, intestinal microbiota damage, dysbiosis, etc., and achieve the effects of low cytotoxicity, prevention of organ adhesion, and excellent antibacterial properties.

Active Publication Date: 2019-01-01
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Broad-spectrum antimicrobial materials can cause severe damage to the gut microbiota, resulting in dysbiosis
Such dysbiosis may result in bacterial overgrowth by competing with microorganisms in the undisturbed flora

Method used

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  • Amino sugar modified antibacterial gold nanoparticle and preparation method thereof, and applications
  • Amino sugar modified antibacterial gold nanoparticle and preparation method thereof, and applications
  • Amino sugar modified antibacterial gold nanoparticle and preparation method thereof, and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] This example is used to illustrate the synthesis of D-glucosamine (GluN) modified antibacterial gold nanoparticles Au_GluN.

[0069] Dissolve D-glucosamine (GluN) (9 mg, 0.042 mmol) in 6 mL of deionized water, add 50 μL of triethylamine and 20 mg of Tween 80 and mix well, then add HAuCl 4 Solution (41mg, 0.1mmol, dissolved in 1mL deionized water), stirred in an ice-water bath for about 10 minutes, under vigorous stirring (1200rpm) was added dropwise fresh NaBH 4 Solution (6mg, 0.15mmol, dissolved in 2mL deionized water, ready to use, to prevent oxidation). The solution turned brown immediately. The stirring speed was then reduced and stirring was continued for 1 hour in an ice-water bath. The solution was then dialyzed against deionized water (14 kDa MW cutoff, Millipore) for 24 hours, filtered and sterilized through a 0.22 μm filter (Millipore), and stored at 4°C. Nanoparticles of the size figure 1 shown.

Embodiment 2

[0071] This example is used to illustrate the synthesis of D-galactosamine (GalN) modified antibacterial gold nanoparticles Au_GalN.

[0072] Dissolve D-galactosamine (GalN) (9 mg, 0.042 mmol) in 6 mL of deionized water, add 50 μL of triethylamine and 20 mg of Tween 80 and mix well, then add HAuCl 4 Solution (41mg, 0.1mmol, dissolved in 1mL deionized water), stirred in an ice-water bath for about 10 minutes, under vigorous stirring (1200rpm) was added dropwise fresh NaBH 4 Solution (6mg, 0.15mmol, dissolved in 2mL deionized water, ready to use, to prevent oxidation). The solution turned brown immediately. The stirring speed was then reduced and stirring was continued for 1 hour in an ice-water bath. The solution was then dialyzed against deionized water (14 kDa MW cutoff, Millipore) for 24 hours, filtered and sterilized through a 0.22 μm filter (Millipore), and stored at 4°C. Nanoparticles of the size figure 1 shown.

Embodiment 3

[0074] This example is used to illustrate the synthesis of D-mannosamine (ManN) modified antibacterial gold nanoparticles Au_ManN.

[0075] Dissolve D-mannosamine (ManN) (9 mg, 0.042 mmol) in 6 mL of deionized water, add 50 μL of triethylamine and 20 mg of Tween 80 and mix well, then add HAuCl 4 Solution (41mg, 0.1mmol, dissolved in 1mL deionized water), stirred in an ice-water bath for about 10 minutes, under vigorous stirring (1200rpm) was added dropwise fresh NaBH 4 Solution (6mg, 0.15mmol, dissolved in 2mL deionized water, ready to use, to prevent oxidation). The solution turned brown immediately. The stirring speed was then reduced and stirring was continued for 1 hour in an ice-water bath. The solution was then dialyzed against deionized water (14 kDa MW cutoff, Millipore) for 24 hours, filtered and sterilized through a 0.22 μm filter (Millipore), and stored at 4°C. Nanoparticles of the size figure 1 shown.

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Abstract

The invention provides an amino sugar modified antibacterial gold nanoparticle and a preparation method thereof, and applications. The prepared antibacterial gold nanoparticle has an excellent antibacterial property, and can resist multidrug resistant bacteria; and the antibacterial gold nanoparticle is good in biocompatibility and low in toxicity to body cells. The antibacterial gold nanoparticlecan be used for clinical wound management, operations to prevent organs from adhering, beauty treatment, and various wound infections such as burn, scald and bedsore infections, so that the antibacterial gold nanoparticle is an extremely excellent medical antibacterial material.

Description

technical field [0001] The invention belongs to the field of nanomaterials, and in particular relates to an amino sugar-modified antibacterial gold nanoparticle and a preparation method and application thereof. Background technique [0002] The widespread use and abuse of antibiotics has led to the fact that most antibacterial drugs have no inhibitory effect on bacteria, making bacteria resistant. With the outbreak of bacterial infectious diseases and the rise of bacteria resistant to antibiotics, there is an urgent need to discover new antimicrobials. In recent years, antibacterial nanomaterials have emerged as promising alternatives to traditional small-molecule antibiotics due to the high surface-to-volume ratio and novel physical and chemical properties of nanoscale nanomaterials. A variety of nanomaterials, such as silver, copper, chitosan, iron oxide, zinc oxide, tellurium and other nanoparticles, and graphene have antibacterial activity. However, most of them are no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/02B22F9/24B82Y40/00A61K33/242A61K9/48A61K47/26A61P31/04A61P17/02A61P41/00A61P17/00
CPCA61K9/4858A61K33/24B82Y40/00B22F9/24B22F1/102B22F1/054
Inventor 蒋兴宇杨兴龙
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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