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A medical composite gel with multiple biological functions, preparation method and application thereof

A composite gel and functional technology, which is applied in the field of medical composite gel preparation, can solve the problems of affecting biological effects, low initial mechanical strength, and destroying porous structures, and achieves low preparation costs, low equipment requirements, and inhibition of cancer cells Effect

Active Publication Date: 2021-06-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing technologies use the preformed method to prepare porous hydrogels, which has the problem of low initial mechanical strength, and more importantly, the implantation process may destroy its porous structure and affect its biological effects.

Method used

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  • A medical composite gel with multiple biological functions, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add 10% of polyvinyl alcohol into deionized water by mass percentage, heat and stir until it is completely dissolved to obtain a gel aqueous solution; after standing at 20°C for 1 hour, a viscous liquid is obtained; pure magnesium particles with an average particle size of 150 μm are % was added to the viscous liquid, stirred and mixed thoroughly, and left to stand at 4°C for 24 hours to obtain a multi-biological functional medical composite gel. Soaked in deionized water, it can absorb 2 times its own weight in water at balance. After absorbing water and balance, its compressive strength is 10±4kPa, and its elongation at break is 200±25%. Other conditions were the same, and the polyvinyl alcohol gel prepared without adding pure magnesium particles was used as the control group.

[0028] After freeze-drying, the microscopic morphology of the composite gel was observed by scanning electron microscopy. See attached figure 1 , which is a scanning electron micrograph of a...

Embodiment 2

[0034] Add sodium alginate 2.5% by mass into deionized water, heat and stir until it is completely dissolved, then cool the aqueous gel solution to 25°C to obtain a viscous liquid; Add 8% by mass to the viscous liquid, stir and mix thoroughly, add 0.1M calcium chloride solution, the gel is fully cross-linked, and after drying, a multi-biological functional medical composite gel is obtained. Soaked in deionized water, it can absorb 10 times its own weight in water at balance. After absorbing water and balance, its compressive strength is 1±0.3kPa, and its elongation at break is 110±15%. Other conditions were the same, and the alginic acid gel prepared without adding magnesium-zinc alloy particles was used as the control group.

[0035] Use the conditions of Example 1 to soak in vitro, and measure the concentration of magnesium ions and zinc ions in the soaking solution before changing the solution for 28 days. The results showed that the magnesium ion concentration in the comp...

Embodiment 3

[0039] Add 20% gelatin to deionized water by mass percentage, heat and stir until it is completely dissolved to obtain a gel aqueous solution; cool the obtained gel aqueous solution to 37°C; 100 mesh zinc-copper (Zn-2Cu) alloy powder 10% was added to the liquid, and under the condition of sufficient stirring, 20% by mass of 1 wt% glutaraldehyde solution was added to obtain a composite gel after rapid cross-linking, and the composite gel was placed at 4°C for 24 hours to fully cross-link. After fully rinsing and drying with deionized water, a multi-biological functional medical composite gel is obtained. Soaked in deionized water, the composite gel can absorb 4.5 times its own weight in water at equilibrium. After water absorption equilibrium, its compressive strength is 100±40kPa, and its elongation at break is 50±7%. Other conditions were the same, and the gelatin gel prepared without adding zinc-copper alloy particles was used as the control group.

[0040] The in vitro imm...

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Abstract

The invention discloses a medical composite gel with multiple biological functions, a preparation method and an application thereof. It uses cross-linked degradable hydrogel as the base material and composites medical degradable metal and / or alloy particles. Through the composition design of the gel base material and degradable metal particles, it has good molding performance and mechanical properties. After being implanted at the site of action, the composite gel can absorb body fluids after contact with body fluids, and the degradable metal / alloy particles on the surface and inside react with body fluids to degrade, release biologically functional ions, gradually form a porous structure, and guide new tissues to grow into ; At the same time, the biologically functional ions released can play the functions of anti-infection, anti-cancer, vascularization, and promotion of regeneration of surrounding tissues. The material provided by the invention can greatly improve the effect of tissue regeneration, has good mechanical properties and rapid prototyping, and can be used in various fields of tissue defect repair, infection and sepsis treatment, cancer treatment and the like.

Description

technical field [0001] The invention relates to a medical composite gel, in particular to a medical composite gel with multiple biological functions, a preparation method and its application, and relates to the fields of biological materials, medical devices, 3D printing, tissue engineering, and medicine and health. Background technique [0002] Gelatin, collagen, alginic acid, polyvinyl alcohol, polyethylene glycol, starch, cellulose, chitosan, hyaluronic acid, chondroitin sulfate and other macromolecular gel materials have excellent hydrophilicity, biocompatibility, Degradability and adjustable mechanical properties have been widely used in medical and health fields such as tissue engineering, drug release, and medical devices. However, gel materials with multiple biological functions, such as those capable of promoting tissue regeneration, vascularization, and anti-infection, are still lacking. [0003] Studies have shown that a suitable porous structure can greatly impr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/00C08J3/075C08L29/04C08L5/04C08L89/00C08K3/08
CPCC08J3/075C08J9/00C08J2305/04C08J2329/04C08J2389/00C08K3/08C08K2003/085C08K2003/0893C08K2201/003
Inventor 林潇杨磊杨惠林
Owner SUZHOU UNIV
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