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A kind of biomedical coating based on graphene and titanium dioxide and preparation method thereof

A titanium dioxide, biomedical technology, applied in the field of biomedicine, can solve the problems of poor responsiveness of biologically active cells, achieve good photoelectric effect, improve adhesion, and improve biocompatibility

Active Publication Date: 2020-10-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its biological activity and cell responsiveness are poor. Therefore, improving the bioresponsiveness and bioactive factor / drug loading capacity of implant materials such as titanium metal is a current research hotspot.

Method used

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  • A kind of biomedical coating based on graphene and titanium dioxide and preparation method thereof
  • A kind of biomedical coating based on graphene and titanium dioxide and preparation method thereof
  • A kind of biomedical coating based on graphene and titanium dioxide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) At first polymethyl methacrylate (PMMA) solution is spin-coated to the graphene surface of graphene / copper sheet with 4000rpm, and spin-coating time is 40s; Then copper sheet is etched in ammonium persulfate solution, at room temperature , the copper sheet was etched for 24 hours; the graphene / PMMA film was rinsed with deionized water and then transferred to the surface of the pickled Ti substrate (100 μm). After natural drying, the PMMA was removed with acetone and dissolved at 60°C for 5 minutes.

[0023] (2) After the Graphene / Ti substrate was rinsed and dried, the TiO 2 Sol dip coating onto graphene surface of Graphene / Ti substrate, TiO 2 Sol 0.1g / mL, dipping density 200mL / m 2 .

[0024] (3) Water evaporates naturally for 1 day, forming TiO on the surface of graphene 2 nano dots.

[0025] The TiO produced in this example 2 / Surface topography and mapping images of graphene / Ti substrate surface scanning electron microscope (SEM) test figure 2 As shown, the...

Embodiment 2

[0027] (1) At first polymethyl methacrylate (PMMA) solution is spin-coated to the graphene surface of graphene / copper sheet with 3000rpm, spin-coating time is 50s; Then copper sheet is etched in ammonium persulfate solution, at room temperature , the copper sheet was etched for 24 hours; the graphene / PMMA film was rinsed with deionized water and transferred to the surface of an acid-washed Ti substrate (1000 μm). After natural drying, the PMMA was removed with acetone and dissolved at 80 ° C for 1 min.

[0028] (2) After the Graphene / Ti substrate was rinsed and dried, the TiO 2 Sol dip coating onto graphene surface of Graphene / Ti substrate, TiO 2 Sol 0.05g / mL, dip coating density 500mL / m2 .

[0029] (3) Water evaporates naturally for 3 days, forming TiO on the surface of graphene 2 nano dots.

[0030] The TiO produced in this example 2 TiO / graphene / Ti substrate 2 The nanometer dots are uniformly distributed, the nanometer size of the titanium dioxide is 50-250nm, and the ...

Embodiment 3

[0032] (1) At first polymethyl methacrylate (PMMA) solution is spin-coated to the graphene surface of graphene / copper sheet with 5000rpm, and the spin-coating time is 30s; Then copper sheet is etched in ammonium persulfate solution, at room temperature , the copper sheet was etched for 24 hours; the graphene / PMMA film was rinsed with deionized water and transferred to the surface of an acid-washed Ti substrate (500 μm). After natural drying, the PMMA was removed with acetone and dissolved at 70°C for 3 minutes.

[0033] (2) After the Graphene / Ti substrate was rinsed and dried, the TiO 2 Sol dip coating onto graphene surface of Graphene / Ti substrate, TiO 2 Sol 0.2g / mL, dipping density 100mL / m 2 .

[0034] (3) Water evaporates naturally for 2 days, forming TiO on the surface of graphene 2 nano dots.

[0035] The TiO produced in this example 2 TiO / graphene / Ti substrate 2 The nano-dots are evenly distributed, the titanium dioxide nano-size is 50-250 nm, and the titanium diox...

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Abstract

The invention discloses a biomedical coating on the basis of graphene and titanium dioxide and a method for preparing the biomedical coating. The biomedical coating is a single-layer graphene and titanium dioxide composite coating. The method for preparing the biomedical coating includes transferring the single-layer graphene on the surfaces of substrates; coating titanium dioxide nano-dots on thesurfaces of the graphene by the aid of dip-coating processes. The biomedical coating and the method have the advantages that the biocompatibility of the substrates can be improved by the biomedical coating formed by the titanium dioxide nano-dots and the graphene, and adhesion of proteins and cells on the surfaces of the substrates can be improved; more importantly, the biomedical coating with the single-layer graphene and the titanium dioxide nano-dots is excellent in ultraviolet light and visible light response, surface charge of the biomedical coating can be regulated, and accordingly thecells adhered on the substrates can be hopefully directionally regulated and controlled; the method for preparing the biomedical coating on the basis of the graphene and the titanium dioxide is simpleand is easy to implement.

Description

technical field [0001] The invention relates to the problem of substrate modification in the field of biomedicine, in particular to a biomedical coating based on graphene and titanium dioxide, which is easy to realize its photoresponse and has good biocompatibility, and a preparation method thereof. Background technique [0002] Promoting or accelerating bone tissue repair performance is the focus of current research on bone repair materials. Among bone repair materials, implant materials such as titanium and titanium alloys are widely used due to their good mechanical properties, biocompatibility and corrosion resistance. In orthopedic and dental surgery. However, its biological activity and cell responsiveness are poor. Therefore, improving the bioresponsiveness and bioactive factor / drug loading capacity of implant materials such as titanium metal is a current research hotspot. [0003] Since its discovery in 2004, graphene has been widely studied in the field of biomedic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/50
CPCA61L27/06A61L27/303A61L27/306A61L27/50A61L2420/02A61L2420/08A61L2430/02
Inventor 程逵龙小军翁文剑
Owner ZHEJIANG UNIV
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