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Amphiphilic chitosan-macadamia nut oil nano-microcapsules and its preparation method and application

A technology of nano-microcapsules and chitosan, applied in the directions of microcapsules, application, capsule delivery, etc., can solve the problems of short fragrance retention time, low antioxidant capacity, and oxidative deterioration.

Active Publication Date: 2021-05-25
AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, macadamia nut oil is unstable at normal temperature and pressure, has low antioxidant capacity and is volatile
During storage, transportation and processing, macadamia nut oil is susceptible to oxidation and deterioration due to factors such as light and heat, and macadamia nut oil is directly applied to cosmetics. When the prepared product is applied to the surface of the skin, the skin absorption effect is poor, Fragrance time is short and other problems, the above problems seriously limit the application and development of macadamia nut oil

Method used

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  • Amphiphilic chitosan-macadamia nut oil nano-microcapsules and its preparation method and application
  • Amphiphilic chitosan-macadamia nut oil nano-microcapsules and its preparation method and application
  • Amphiphilic chitosan-macadamia nut oil nano-microcapsules and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 amphiphilic chitosan

[0043] (1) Get the chitosan that viscosity is not more than 200mPa.s, be configured into the chitosan aqueous solution that mass concentration is 1.0% with the glacial acetic acid aqueous solution of 1.0% with mass concentration; Get stearic acid, be configured with dehydrated alcohol into mass concentration Concentration is the ethanol solution of stearic acid of 2.0%;

[0044] (2) getting 1kg of the above-mentioned mass concentration of 1.0% chitosan aqueous solution and 1kg of the above-mentioned mass concentration of 2.0% stearic acid ethanol solution, mix, stir and add 10g of 1-ethyl-3-(3-di Methylaminopropyl) carbodiimide hydrochloride, at a temperature of 80°C and a stirring speed of 3000rpm, stirring and reacting for 3h, grafting stearic acid into chitosan molecules as a hydrophobic group to obtain hard Stearic acid grafted chitosan with fatty acid hydrophobic group grafting ratio of 5%;

[0045] (3) Step ...

Embodiment 2

[0048] The preparation of embodiment 2 amphiphilic chitosan

[0049] (1) Get the chitosan that viscosity is not more than 200mPa.s, be configured into the chitosan aqueous solution that mass concentration is 3.0% with the glacial acetic acid aqueous solution of 1.0% with mass concentration; Get stearic acid, be configured with dehydrated alcohol into mass concentration Concentration is the ethanol solution of stearic acid of 5.0%;

[0050] (2) getting 1kg of the above-mentioned mass concentration of 3.0% chitosan aqueous solution and 1kg of the above-mentioned mass concentration of 5.0% stearic acid ethanol solution, mix, stir and add 100g of 1-ethyl-3-(3-di Methylaminopropyl) carbodiimide hydrochloride, at a temperature of 80°C and a stirring speed of 1000rpm, stirring and reacting for 5h, grafting stearic acid into the chitosan molecule as a hydrophobic group to obtain hard Stearic acid grafted chitosan with fatty acid hydrophobic group grafting ratio of 20%;

[0051] (3) ...

Embodiment 3

[0052] The preparation of embodiment 3 amphiphilic chitosan

[0053] (1) Get the chitosan that viscosity is not more than 200mPa.s, be configured into the chitosan aqueous solution that mass concentration is 2.0% with the glacial acetic acid aqueous solution of 1.0% with mass concentration; Get stearic acid, be configured with dehydrated alcohol into mass concentration Concentration is the stearic acid ethanol solution of 3.0%;

[0054] (2) get 1kg above-mentioned mass concentration and be that the chitosan aqueous solution of 2.0% and 1kg above-mentioned mass concentration are the stearic acid ethanol solution of 3.0%, mix, add 80g of 1-ethyl-3-(3-di Methylaminopropyl) carbodiimide hydrochloride, at a temperature of 80°C and a stirring speed of 2000rpm, stirring and reacting for 4h, grafting stearic acid into the chitosan molecule as a hydrophobic group to obtain hard Stearic acid grafted chitosan with fatty acid hydrophobic group grafting ratio of 10%;

[0055] (3) Add 140...

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Abstract

The invention discloses an amphiphilic chitosan and a preparation thereof. The amphiphilic chitosan is chitosan grafted with stearic acid and N-acetyl-L-cysteine ​​and has a molecular weight of 10-300 kDa. When the amphiphilic chitosan of the present invention is used as a nano-microcapsule embedding wall material, it can embed hydrophobic substances to form water-soluble nano-microcapsule solids, and can also be used as an embedding wall material for hydrophilic substances to form Non-water-soluble nano-microcapsules. The invention also discloses an amphiphilic chitosan-macadamia nut oil nano-microcapsule and its preparation method and application. The nano-microcapsule is formed by embedding a core material in a wall material, the core material is macadamia nut oil, and the wall material is The amphiphilic chitosan provided by the invention. The nanometer microcapsule provided by the invention has high embedding rate, good dispersibility and uniformity, and after the macadamia nut oil is embedding with amphiphilic chitosan, the volatility is reduced, and the stability and bioavailability are significantly improved.

Description

technical field [0001] The invention belongs to the technical field of modification of chitosan and preparation of nano-microcapsules, and specifically relates to amphiphilic chitosan and its preparation method, and amphiphilic chitosan-macadamia nut oil nano-microcapsules and its preparation method and application . Background technique [0002] Macadamia nut, also known as macadamia walnut, Queensland fruit, macadamia nut, etc., is a tree nut native to Australia. It has high nutritional value and medicinal value, and is known as the "king of dried fruits". The Chinese patent with the publication number CN103834470A discloses a method for extracting macadamia nut oil using subcritical extraction technology. Using subcritical extraction technology, under a certain pressure and temperature, the dried and crushed macadamia nuts are extracted multiple times to obtain high-quality oil. Quality Macadamia Nut Oil. In addition, macadamia nut oil can also be obtained by cold press...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/185A61K47/36A61K8/92A61K8/73A61K8/11A23L33/12A23P10/30A61P3/06A61P3/10A61P9/12
CPCA61K8/11A61K8/736A61K8/922A61K9/0095A61K9/5036A61K36/185A61Q19/02A61Q19/10A23L29/30A23L33/12A23P10/30A61P3/06A61P3/10A61P9/12
Inventor 杨子明李普旺李思东吕明哲陶金龙周闯王超何祖宇陈日志王慧
Owner AGRI PRODS PROCESSING RES INST CHINESE ACAD OF TROPICAL AGRI SCI
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