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Application of panax notoginseng saponins in preparing NLRP3 inflammasome-restraining drugs or drugs for treating tristimania

A technology of Panax notoginseng saponins and inflammasomes, which can be used in drug combinations, antipyretics, anti-inflammatory agents and other directions to achieve the effect of improving depressive behavior

Inactive Publication Date: 2018-12-07
NANHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report in the literature that Panax notoginseng saponins can inhibit the depression caused by the formation of NLRP3 inflammasomes, and based on this, there are related studies on the treatment of central nervous system diseases

Method used

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  • Application of panax notoginseng saponins in preparing NLRP3 inflammasome-restraining drugs or drugs for treating tristimania
  • Application of panax notoginseng saponins in preparing NLRP3 inflammasome-restraining drugs or drugs for treating tristimania
  • Application of panax notoginseng saponins in preparing NLRP3 inflammasome-restraining drugs or drugs for treating tristimania

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Real-time fluorescent quantitative PCR method to investigate the effect of Panax notoginseng saponins on the activation of microglial cells in the hippocampus and NLRP3 inflammasome in LPS-induced depression model mice

[0037] Animals: 32 male Kunming mice, 3 months old, weighing about 25g. Animals were kept at room temperature (22±2)°C, humidity (45%-65%) and light and dark (12h:12h) environment, free to eat and drink. Animal grouping and treatment The mice were divided into 4 groups according to the random number table method: normal control group (NS, n=8), neuroinflammation model group (LPS, n=8), Panax notoginseng saponins (LPS+PNS, n=8) 8), positive drug fluoxetine (LPS+Flu, n=8), before LPS injection, notoginseng total saponins once a day i.p, a total of 4 days of treatment; before LPS injection, positive drug fluoxetine daily 1 i.p. treatment for 7 days.

[0038] Drugs: LPS, 0.5mg / kg; Panax notoginseng saponins, 100mg / kg; Fluoxetine, 10mg / kg.

[0...

Embodiment 2

[0055] Example 2: Investigating the effect of Panax notoginseng saponins on the behavior of LPS-induced depression model mice

[0056] Animals: 32 male Kunming mice, 3 months old, weighing about 25g. Animals were kept at room temperature (22±2)°C, humidity (45%-65%) and light and dark (12h:12h) environment, free to eat and drink. Animal grouping and treatment The mice were divided into 4 groups according to the random number table method: normal control group (NS, n=8), neuroinflammation model group (LPS, n=8), Panax notoginseng saponins (LPS+PNS, n=8) 8), the positive drug fluoxetine (LPS+Flu, n=8), Panax notoginseng saponins once a day i.p, a total of 4 days of treatment; the positive drug fluoxetine once a day i.p, a total of 7 days of treatment. One hour after the last drug injection, the LPS group and the LPS+PNS group were intraperitoneally injected with 0.5 mg / kg LPS, and the open field test and forced swimming test were performed on the 8th day. Since the shortening ...

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Abstract

The invention relates to the technical field of new applications of drugs and especially relates to an application of panax notoginseng saponins in preparing NLRP3 inflammasome-restraining drugs or drugs for treating tristimania. A test result proves that panax notoginseng saponins is capable of obviously restraining activation of LPS-induced rat hippocampal microglia and release of NLRP3 inflammasome and IL-1 beta and IL-18 and can be used for treating tristimania induced by abnormal increasing of microglia NLRP3 inflammasome.

Description

technical field [0001] The invention relates to the technical field of new application of drugs, in particular to the application of Panax notoginseng saponins in the preparation of drugs for inhibiting NLRP3 inflammasomes or drugs for treating depression. Background technique [0002] The NLRP3 inflammasome has the function of regulating the chronic inflammatory response of the body, and its composition includes NLRP3 (NLRfamily, pyrin domain containing 3), apoptosis-associated speck-like protein containing CARD (ASC) and cysteine ​​day Cysteine-requiring aspartate protease-1 (Caspase-1), a cytoplasmic sensor of endogenous or exogenous danger signals, is a molecular platform for activating caspase-1, and regulates interleukin- Maturation and secretion of pro-inflammatory cytokines such as 1β (Interleukin-1β, IL-1β) and IL-18. [0003] NLRP3 is one of the danger signal receptors in innate immune cells, which can be activated by various pathogen-associated molecular patterns...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P29/00A61P25/24
CPCA61K36/258A61P25/24A61P29/00
Inventor 万炜何洁钟小林陈熙曹文宇徐杨刘政海曾佳玉
Owner NANHUA UNIV
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