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A kind of preparation method of L-arginine hydrochloride

A technology of arginine hydrochloride and arginine, applied in the field of preparation of L-arginine hydrochloride, can solve the problems of waste of energy, low efficiency, low yield, etc., and achieve improved yield and production efficiency , cost saving, high purity effect

Active Publication Date: 2021-06-11
WUXI JINGHAI AMINO ACID
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are great defects in the above method, for example: low yield, low efficiency, not suitable for application production; concentration and catch ammonia need to use a large amount of steam, waste of energy, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Specific steps are as follows:

[0038] (1) After the arginine fermentation broth was passed through the sterilization film, it was adsorbed by the regenerated 732 resin with a volume of 2L, and the adsorption rate was 20mL / min. The rapid point acid method was used to determine whether there was amino acid leakage in the adsorption discharge liquid. Stop the adsorption when there is leakage of amino acid. The adsorption volume is 6.5L. After washing the resin with 6L of purified water, use 2% sodium hydroxide to elute to obtain 8L of liquid A;

[0039] (2) Put the 8LA liquid in (1) into the decolorization tank for decolorization, the decolorization temperature is 60°C, the time is 30min, the amount of activated carbon is 5‰ of the volume of liquid A, that is 40g, the stirring speed is 200r / min, and the activated carbon is removed by filtration , to obtain a decolorizing solution;

[0040] (3) The temperature of the decolorizing solution in (2) is reduced to 40° C., and...

Embodiment 2

[0045] Specific steps are as follows:

[0046] (1) After the arginine fermentation liquid was passed through the sterilization film, it was adsorbed by the regenerated 732 resin with a volume of 2L. The adsorption rate was 15mL / min. The rapid point acid method was used to determine whether there was amino acid leakage in the adsorption discharge liquid. Stop the adsorption when there is leakage of amino acid. The adsorption volume is 6.5L. After washing the resin with 6L of purified water, use 2% sodium hydroxide to elute to obtain 8L of liquid A;

[0047] (2) Put the 8LA solution in (1) into a decolorization tank for decolorization, the decolorization temperature is 55°C, the time is 1h, the amount of activated carbon is 5‰ of the volume of A solution, that is, 40g, the stirring speed is 250r / min, and the activated carbon is removed by filtration , to obtain a decolorizing solution;

[0048] (3) The temperature of the decolorizing solution in (2) is reduced to 35° C., and th...

Embodiment 3

[0053] Specific steps are as follows:

[0054] (1) After the arginine fermentation liquid was passed through the sterilization film, it was adsorbed by the regenerated 732 resin with a volume of 2L. The adsorption rate was 15mL / min. The rapid point acid method was used to determine whether there was amino acid leakage in the adsorption discharge liquid. Stop the adsorption when there is leakage of amino acid. The adsorption volume is 6.5L. After washing the resin with 6L of purified water, use 2% sodium hydroxide to elute to obtain 8L of liquid A;

[0055] (2) Put the 8LA liquid in (1) into the decolorization tank for decolorization, the decolorization temperature is 60°C, the time is 30min, the amount of activated carbon is 5‰ of the volume of liquid A, that is 40g, the stirring speed is 180r / min, and the activated carbon is removed by filtration , to obtain a decolorizing solution;

[0056] (3) Reduce the temperature of the decolorizing solution in (2) to below 40°C, use a ...

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Abstract

The invention discloses a preparation method of L-arginine hydrochloride, which belongs to the technical field of separation and extraction. In the method of the present invention, the arginine fermentation liquid is firstly adsorbed with a strong-acid cation exchange resin, eluted with a sodium hydroxide solution to obtain an arginine solution, then adsorbed with a weakly acidic cation-exchange resin, and eluted with hydrochloric acid. Obtain arginine hydrochloride solution, and finally decolorize and concentrate to obtain arginine hydrochloride; the method of the present invention avoids elution with ammonia water, and no longer needs to use a large amount of steam to catch ammonia, thereby saving costs ; Simultaneously, this method has introduced novel resin technology, can remove the acidic and neutral amino acid impurity in arginine hydrochloride, the arginine hydrochloride purity that makes preparation is higher, and improved arginine to a great extent Yield and preparation efficiency of hydrochloride finished product.

Description

technical field [0001] The invention relates to a preparation method of L-arginine hydrochloride, belonging to the technical field of separation and extraction. Background technique [0002] Arginine is a basic amino acid and one of the 20 main amino acids. It participates in the ornithine cycle in the metabolic process in organisms. It is a semi-essential amino acid in the human body. It has been widely used in medicine, food and cosmetics superior. [0003] In recent years, with the development of industry, the demand for arginine in various fields has been increasing. However, so far, most of the domestic arginine still needs to be imported from abroad, and a large part of the reason is that domestic arginine The backwardness of the extraction process. [0004] Domestic arginine extraction mainly relies on the traditional ion exchange method. The ion exchange method is generally to first use cation exchange resin to adsorb arginine in the fermentation broth, then use a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C279/14C07C277/08
CPCC07C277/08C07C279/14
Inventor 宁健飞蔡立明陈晓双
Owner WUXI JINGHAI AMINO ACID
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