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Heparin derivative-poloxamer temperature sensitive hydrogel and preparation method thereof

A technology of heparin derivatives and hydrogels, applied in the field of biomedical materials, can solve problems such as unapplied reports, reduce the number of dressing changes and improve compliance

Inactive Publication Date: 2018-11-30
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In addition, the study of sustained-release preparations has important theoretical significance and application prospects in the nursing process of diabetic wounds, but there are no reports of applications

Method used

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  • Heparin derivative-poloxamer temperature sensitive hydrogel and preparation method thereof
  • Heparin derivative-poloxamer temperature sensitive hydrogel and preparation method thereof
  • Heparin derivative-poloxamer temperature sensitive hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Preparation of heparin derivative-poloxamer thermosensitive hydrogel Weigh 15-90 mg of N-acetylated low molecular weight heparin and put it in a serum bottle, add 1 mL of PBS buffer solution (pH=7.0), prednisone drug PBS Buffer solution (mass concentration 5%); stir and dissolve at room temperature for 24 hours. Weigh poloxamer (100-300mg P407) and add the above low molecular weight heparin solution (V is 1-3mL), stir and dissolve at 4°C for 24h, put the vial of heparin-poloxamer mixture in a water bath, and heat slowly The temperature was raised, and the gelation temperature and gelation time were judged and determined by the inverted bottleneck method.

Embodiment 2

[0033] PLGA-heparin derivatives-poloxamer thermosensitive hydrogel was prepared with PLGA as the carrier material. Prednisone microspheres were prepared by the W / O / W double emulsion-drying method with simple process and convenient operation. The prednisone solution of 5% mass concentration is added in the dichloromethane solution of the PLGA of 10% mass concentration, forms colostrum after ultrasonic dispersion; With 6% PVA solution as aqueous dispersion medium, its inorganic salt mass concentration is 2% . Add 2mL of PVA solution dropwise to the above-mentioned emulsion, after homogenization, pour this solution into 8mL of PVA solution of the same concentration, and stir magnetically at room temperature for 3-5h to obtain the prednisone-PLGA colloidal solution.

[0034] Weigh 15-90 mg of N-acetylated low molecular weight heparin and put it in a serum bottle, add 1 mL of PBS buffer solution (pH=7.0), prednisone-PLGA drug colloid solution; stir and dissolve at room temperature...

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Abstract

The invention discloses a heparin derivative-poloxamer temperature sensitive hydrogel and a preparation method thereof. The poloxamer is used as a framework material, and N-Acetylated low molecular weight heparin and prednisone are compounded to obtain the hydrogel. The mass ratio of the N-Acetylated low molecular weight heparin to the poloxamer is 15-90:100-300. The preparation method comprises the following steps that step 1, the N-Acetylated low molecular weight heparin is weighed and placed in a serum bottle, and a PBS buffer solution is added; step 2, a prednisone drug PBS buffer solutionwith mass concentration of 5% is added, stirring at the room temperature is conducted and lasts for 12-36 hours; and step3, the poloxamer is weighed, and the solution in the step 2 is added, solutionstirring is conducted at 4-10 DEG C and last for 12-36 hours. The heparin derivative-poloxamer temperature sensitive hydrogel has the excellent effect, is long in antibacterial time, and has simple procedures; and industrialization can be achieved easily, and popularization and application are facilitated.

Description

technical field [0001] The invention belongs to biomedical material technology, and in particular relates to a heparin derivative-poloxamer temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Diabetic non-healing ulcer is one of the most serious and costly chronic complications of diabetes. Compared with normal wounds, diabetic ulcers tend to protracted healing. Diabetic foot patients often form local wounds after debridement, and the wounds are often accompanied by more exudate after opening. According to the condition of the patient's wound, it is necessary to change the dressing regularly to reduce the colonization of bacteria on the wound and promote the growth of wound granulation. However, in the process of dressing change, especially during the growth of wound granulation, the blood supply is rich and the sensation is sensitive. When changing the dressing, it is easy to cause local bleeding, and the patient feels severe pai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/727A61K31/573A61K47/10A61K9/06A61K9/12A61P17/02
CPCA61K9/0014A61K9/06A61K9/12A61K31/573A61K31/727A61K47/10A61P17/02A61K2300/00
Inventor 陈敬华闫昳姝刘晓妮毛静邱立朋赵朋
Owner JIANGNAN UNIV
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