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Method for preparing CPP fiber-containing phosphate bone cement composite material

A technology of composite materials and bone cement, which is applied in the fields of pharmaceutical formulation, medical science, capsule delivery, etc., can solve the problems of mismatching new bone growth rate, inflammatory response, high brittleness, etc., achieve high strength, control drug release, improve The effect of stability

Inactive Publication Date: 2018-11-23
许水仙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention: Aiming at the disadvantages of phosphate materials such as high brittleness, low strength, mismatch with new bone growth rate, and inflammatory reaction after implantation into the human body, a kind of phosphate containing CPP fiber is provided. Preparation method of phosphate bone cement composite material

Method used

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  • Method for preparing CPP fiber-containing phosphate bone cement composite material

Examples

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Effect test

example 1

[0022] Dissolve chitosan powder in 2% acetic acid solution to make a 1.5% chitosan-acetic acid solution, preheat the 15% gelatin solution and liquid paraffin to 50°C to obtain the preheated After heating, the mass fraction is 15% gelatin solution and preheated liquid paraffin, and the mass fraction is 1.5% chitosan-acetic acid solution and the preheated mass fraction is 15% gelatin solution mixed evenly by volume ratio 1:1 , to obtain mixed solution A; mix Span-80 and Tween-80 uniformly at a mass ratio of 1:1 to obtain a composite emulsifier; add the composite emulsifier to liquid paraffin at a mass ratio of 1:10 to obtain an emulsion, and obtain an emulsion by mass ratio Add the mixed solution A to the emulsion dropwise at 1:5, stir at room temperature for 2 hours at a stirring speed of 1500r / min to obtain the mixed solution B, and centrifuge the mixed solution B at a centrifugal radius of 7cm and a rotating speed of 1000r / min for 5min to obtain a precipitate , the precipitat...

example 2

[0024]Dissolve chitosan powder in 2% acetic acid solution to make a 1.5% chitosan-acetic acid solution, preheat the 15% gelatin solution and liquid paraffin to 50°C to obtain the preheated After heating, the mass fraction is 15% gelatin solution and preheated liquid paraffin, and the mass fraction is 1.5% chitosan-acetic acid solution and the preheated mass fraction is 15% gelatin solution mixed evenly by volume ratio 1:1 , to obtain mixed solution A; mix Span-80 and Tween-80 uniformly at a mass ratio of 1:1 to obtain a composite emulsifier; add the composite emulsifier to liquid paraffin at a mass ratio of 1:10 to obtain an emulsion, and obtain an emulsion by mass ratio Add the mixed solution A to the emulsion dropwise at 1:5, stir at room temperature for 2.5 hours at a stirring speed of 1750r / min to obtain a mixed solution B, and centrifuge the mixed solution B at a centrifugal radius of 11cm and a rotating speed of 1250r / min for 8min to obtain a precipitate The precipitate ...

example 3

[0026] Dissolve chitosan powder in 2% acetic acid solution to make a 1.5% chitosan-acetic acid solution, preheat the 15% gelatin solution and liquid paraffin to 50°C to obtain the preheated After heating, the mass fraction is 15% gelatin solution and preheated liquid paraffin, and the mass fraction is 1.5% chitosan-acetic acid solution and the preheated mass fraction is 15% gelatin solution mixed evenly by volume ratio 1:1 , to obtain mixed solution A; mix Span-80 and Tween-80 uniformly at a mass ratio of 1:1 to obtain a composite emulsifier; add the composite emulsifier to liquid paraffin at a mass ratio of 1:10 to obtain an emulsion, and obtain an emulsion by mass ratio Add the mixed solution A to the emulsion at a ratio of 1:5, and stir at room temperature for 3 hours at a stirring speed of 2000r / min to obtain a mixed solution B. Centrifuge the mixed solution B at a centrifugal radius of 14cm and a rotational speed of 1500r / min for 10min to obtain a precipitate , the precip...

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Abstract

The invention relates to a method for preparing a CPP fiber-containing phosphate bone cement composite material, and belongs to the technical field of medical repair materials. A microsphere materialis prepared by using gelatin and chitosan, and has the functions of controlling drug release and prolonging the therapeutic effect of the drug, thereby improving the stability of the drug and reducingthe adverse reaction of the drug, and at the same time, the microsphere material has an anti-inflammatory effect, and the gelatin-chitosan microsphere has good biocompatibility; when the gelatin-chitosan microsphere / calcium phosphate bone cement is in a body fluid environment, the microsphere is dissolved into a liquid, and the gelatin and the chitosan slowly precipitate out in a liquid state, sothat the whole stent is encapsulated by the gelatin and the chitosan. The cross-section of the material provided by the invention internally has a three-dimensional network communicated microporous structure, the micropores are distributed more uniformly, and the three-dimensional communicated reticular spatial structures are beneficial to the bone and cartilage tissues to play a specific physiological role, have high strength, and do not cause an inflammatory reaction after being implanted into the human body.

Description

technical field [0001] The invention relates to a preparation method of a phosphate bone cement composite material containing CPP fibers, belonging to the technical field of medical repair materials. Background technique [0002] Bone cement materials are mainly used in the treatment of bone defects in organisms, and can support the affected part after filling to avoid secondary injuries. In general, bone cement consists of a powder composed of bone substitute material and a water agent for mixing, which is mixed before use to make it fluid. The nature of the fluid is relatively easy to achieve tight packing, and must be cured in a short time after implantation to prevent damage from body fluids. Of course, the structural strength after curing must also be sufficient to support the affected part in order to avoid secondary injuries. [0003] Bone cement materials rarely emphasize the importance of porosity due to the need to maintain structural strength. The bone cement m...

Claims

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Application Information

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IPC IPC(8): C04B28/34A61L27/42A61L27/56
CPCA61L27/425A61L27/56A61L2300/102A61L2300/232A61L2300/41A61L2300/412A61L2300/622A61L2430/02A61L2430/06C04B28/344C04B2201/50C04B14/38C04B14/28C04B22/10C04B24/14C04B24/38C08L89/00C08L5/08
Inventor 许水仙张鑫李静
Owner 许水仙
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