Pueraria flavone micro pill prepn and its prepn process

A Pueraria flavonoid pellets and technology of Pueraria flavonoids, which are applied in the field of medicine, can solve the problems of low bioavailability of Yufeng Ningxin dripping pills, cannot meet the modernization requirements of traditional Chinese medicine preparations, and cannot meet the needs of clinical medication, etc., so as to improve bioavailability degree, reduce or eliminate local irritation, low cost effect

Inactive Publication Date: 2007-09-05
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because puerarin injections bring inconvenience to patients; and the bioavailability of Yufeng Ningxin Dropping Pills is not high, and the bioavailability of Yufeng Ningxin Tablets is even lower. "preparation method" invention patent, but the pellets of this invention disintegrate in a short time, the drug release is extremely unstable, and cannot meet the needs of clinical medication; the manufacturing method of this invention is manual generalization, and it cannot meet the modernization requirements of traditional Chinese medicine preparations

Method used

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  • Pueraria flavone micro pill prepn and its prepn process
  • Pueraria flavone micro pill prepn and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Pueraria flavonoid pellet preparation and preparation method

[0022] Prescription composition:

[0023] Pueraria flavonoids 12.5g

[0024] Microcrystalline Cellulose 30g

[0025] Micronized silica gel 7.5g

[0026] 50% ethanol 31mL

[0027] Preparation:

[0028] Take kudzu flavonoids, microcrystalline cellulose and micropowder silica gel according to the above ratio, pass through a 60-mesh sieve and mix well, then add 31mL of 50% ethanol and mix well, and then use the extrusion spheronization method to make particles with a diameter of less than 2.5mm Dry at 60°C under normal pressure to prepare the pellet preparation of the present invention. Results The measured yield was 95%, the roundness of the pellets was good, and the drug release was stable.

Embodiment 2

[0030] Pueraria flavonoid pellet preparation and preparation method

[0031] Prescription composition:

[0032] Pueraria flavonoids 12.5g

[0033] Microcrystalline Cellulose 32.5g

[0034] Lactose 5g

[0035] Water 32.5mL

[0036] Preparation:

[0037] Take kudzu flavonoids, microcrystalline cellulose and lactose according to the above ratio, pass through a 120-mesh sieve and mix well, then add 32.5mL of water and mix well, and then use the fluidized bed pelleting method to make particles with a diameter of less than 2.5mm in 50 ℃ and dried under reduced pressure to prepare the pellet preparation of the present invention. Results The measured yield was 92%, the roundness of the pellets was good, and the drug release was stable.

Embodiment 3

[0039] Pueraria flavonoid pellet preparation and preparation method

[0040] Prescription composition:

[0041] Pueraria flavonoids 22.5g

[0042] Starch 30.5g

[0043] Lactose 7.5g

[0044] Water 30.5mL

[0045] Preparation:

[0046] Take kudzu flavonoids, starch and lactose according to the above ratio, pass through a 120-mesh sieve and mix well, then add 30.5mL of water and mix well, then use the layered pelleting method to make particles with a diameter of less than 2.5mm, and then depressurize at 50°C Dried to make the pellet preparation of the present invention. Results The measured yield was 94%, the roundness of the pellets was good, and the drug release was stable.

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Abstract

The present invention belongs to the field of medicine technology, and discloses pueraria flavone micro pill preparation as one new preparation form of pueraria flavone and its preparation process. The pueraria flavone micro pill preparation has raised pueraria flavone bioavailability, relatively low production cost, and simple preparation process. The pueraria flavone micro pill preparation is compounded with pueraria flavone, supplementary material, wetter or adhesive, and has micro pill diameter smaller than 2.5 mm. The preparation process includes the steps of: 60-120 mesh sieving pueraria flavone and supplementary material, mixing, adding wetter or adhesive and mixing, pelletizing and drying.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a traditional Chinese medicine pellet preparation and a preparation method thereof, in particular to a new drug dosage form of pueraria flavonoids——pueraria flavone pellet preparation and a preparation method thereof. Background technique [0002] Pueraria lobata (Willd.) Ohwi is a brownish-yellow powder extracted and refined from the traditional Chinese medicine Pueraria lobata (Willd.) Ohwi, and its main component is puerarin. Pueraria flavonoids have significant pharmacological effects such as reducing myocardial oxygen consumption, expanding coronary vessels, increasing coronary and cerebrovascular blood flow, anti-arrhythmia, anti-oxidation, enhancing immunity, and lowering blood sugar. Puerarin is widely used clinically because of its definite curative effect, wide safety range and low toxicity. Clinically, kudzu root flavonoid preparations are mainly used to treat coronary heart dis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/16A61P9/12A61P9/10A61P27/02
Inventor 陈彦贾晓斌成旭东范晨怡
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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