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Composition of chalcone and acetic acid type non-steroidal anti-inflammatory drugs and application

A technology of non-steroidal anti-inflammatory drugs and compositions, applied in the field of synergistic anti-inflammatory effect, can solve the problems of chalcone and non-steroidal anti-inflammatory drugs that have not been reported, and achieves reduction of clinical dosage, reduction of side effects, and good anti-inflammatory properties. inflammatory effect

Pending Publication Date: 2018-11-23
GUANGDONG IND TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the structural modification of chalcone mainly focuses on the chemical modification of its active functional groups, and there is no report on the anti-inflammatory combination of chalcone and non-steroidal anti-inflammatory drugs

Method used

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  • Composition of chalcone and acetic acid type non-steroidal anti-inflammatory drugs and application
  • Composition of chalcone and acetic acid type non-steroidal anti-inflammatory drugs and application
  • Composition of chalcone and acetic acid type non-steroidal anti-inflammatory drugs and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Effect of Composition on Mouse Inflammation Model

[0022] 1.1 Experimental materials

[0023] SPF grade KM mice, female, weighing about 18-22 g, were provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine (certificate number: SCXK / 20130002). Hole punch (diameter 6mm), purchased by yourself.

[0024] 1.2 Experimental method

[0025] Eighteen female KM mice were randomly divided into blank control group, TPA-induced inflammation group, positive control drug chalcone group and acetic acid non-steroidal anti-inflammatory drug group, 1:1 composition group, 2:1 composition group A total of 6 groups, 3 in each group. After smearing on the ears (the drug concentration is 0.75 μM, and the volume of one ear is 7.5 μL), 10 minutes later, the same amount of 1.5nM TPA 15 μL was applied to the front and back sides of the left and right ears of mice in each group to cause inflammation. After 6 hours, the mice were killed by d...

Embodiment 2

[0045] Example 2: Effect of Composition on Mouse Inflammation Model

[0046] 2.1 Effects on TPA-induced ear swelling in mice

[0047] In order to investigate the effect of the concentration of the chalcone composition on the inhibitory effect of the mouse auricle swelling, different drugs were applied to the ears of the mice according to the above animal model. The effects of different chalcone compositions on mouse auricle swelling inhibition were measured by recording the weight of the auricle of the mouse, and acetone was used as a control.

[0048] The influence of table 5 composition on TPA-induced mouse auricle swelling

[0049]

[0050] Compared to the negative control group,*: P <0.05.

[0051]As shown in Table 5, the inhibition rate of the parent drug chalcone alone was 35.8%, and that of etodolac was 21.5%. The inhibition rate of all compositions is greater than 35.8%. Moreover, among these compounds, 15 compositions have obvious inhibitory effects on TPA-ind...

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PUM

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Abstract

The invention discloses a composition of chalcone and acetic acid type non-steroidal anti-inflammatory drugs and application. The composition is prepared from chalcone and acetic acid type non-steroidal anti-inflammatory drugs in a certain weight ratio, specially (11 to 1) to (1 to 11). The composition of chalcone and acetic acid type non-steroidal anti-inflammatory drugs specially play synergistic effects on treatment or prevention of diseases, such as dermatitis, arthritis and rheumatoid arthritis, particularly on dermatitis.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compounds, in particular to the synergistic anti-inflammatory effect of the composition of chalcone and acetic acid non-steroidal anti-inflammatory drugs and its application. Background technique [0002] Acetate nonsteroidal anti-inflammatory drugs (NSAIDs) include indomethacin, etodolac, sulindac, and diclofenac. They are a class of drugs with antipyretic, analgesic and anti-inflammatory effects, belonging to Class B non-prescription drugs, and are currently widely used in the treatment of fever, pain, inflammatory diseases, rheumatic diseases, and soft tissue and sports injuries. However, long-term high-dose oral NSAIDs will bring potential side effects and adverse reactions to patients, such as gastrointestinal bleeding, liver and kidney damage, and cardiovascular damage. The skin smear preparation has many advantages such as avoiding the first-pass effect of the liver and reduces side...

Claims

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Application Information

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IPC IPC(8): A61K31/407A61K31/405A61K31/192A61K31/196A61K31/12A61P29/00A61P17/00
CPCA61K31/12A61K31/192A61K31/196A61K31/405A61K31/407A61K2300/00
Inventor 李永莲
Owner GUANGDONG IND TECHN COLLEGE
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