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Polypyrrole-polyvinylpyrrolidone nanoparticles and preparation method and application thereof

A polyvinylpyrrolidone and polypyrrole nanotechnology, applied in the field of materials science, can solve the problems of difficult metabolism of copper sulfide nanoparticles, low light absorption coefficient of carbon materials, low light-to-heat conversion efficiency, etc., and achieve good blood compatibility and biological Compatibility, simple and easy preparation method, remarkable effect of technological progress

Inactive Publication Date: 2018-11-23
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These materials usually require a relatively complicated preparation process, and there are some functional defects
For example, gold nanorods will undergo shape changes under light conditions, resulting in absorption shifts, copper sulfide nanoparticles are not easy to metabolize in vivo, and carbon materials have low light absorption coefficient and low light-to-heat conversion efficiency, etc., which limit their further development. application

Method used

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  • Polypyrrole-polyvinylpyrrolidone nanoparticles and preparation method and application thereof
  • Polypyrrole-polyvinylpyrrolidone nanoparticles and preparation method and application thereof
  • Polypyrrole-polyvinylpyrrolidone nanoparticles and preparation method and application thereof

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Embodiment 1

[0040] Add PVP with a molecular weight of 40kDa and a concentration of 25mg / mL to distilled water, stir to dissolve and add 2.48g of FeCl 3 ·6H 2 O. At a temperature of 4°C, pyrrole was added to react for 4h. The resulting solution was centrifuged and washed to obtain PPy-PVP 40kDa Nanoparticles ( figure 1 a,b). Use Image J 1.40G software to measure the diameter of nanoparticles (measure at least 50), PPy-PVP 40kDa The diameter of the nanoparticles is 74.15nm, PVP 40kDa The addition of effectively improved the colloidal stability of PPy nanoparticles ( figure 2 a, b).

Embodiment 2

[0042] Add PVP with a molecular weight of 360kDa and a concentration of 25mg / mL to distilled water, stir to dissolve and add 2.48g of FeCl 3 ·6H 2 O. At a temperature of 4°C, pyrrole was added to react for 4h. The resulting solution was centrifuged and washed to obtain PPy-PVP 360kDa Nanoparticles ( figure 1c, d). Use Image J 1.40G software to measure the diameter of nanoparticles (measure at least 50), PPy-PVP 360kDa The particle size of nanoparticles is 74.55nm, PVP 360kDa The addition of effectively improved the colloidal stability of PPy nanoparticles ( figure 2 c, d).

Embodiment 3

[0044] Add PVP with a molecular weight of 1300kDa and a concentration of 25mg / mL to distilled water, stir to dissolve and add 2.48g of FeCl 3 ·6H 2 O. At a temperature of 4°C, pyrrole was added to react for 4h. The resulting solution was centrifuged and washed to obtain PPy-PVP 1300kDa Nanoparticles ( figure 1 e, f). Use Image J 1.40G software to measure the diameter of nanoparticles (measure at least 50), PPy-PVP 1300kDa The particle size of nanoparticles is 68.98nm, PVP 1300kDa The addition of effectively improved the colloidal stability of PPy nanoparticles ( figure 2 e, f).

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Abstract

The invention provides polypyrrole-polyvinylpyrrolidone nanoparticles are formed by synchronously surface-modifying polyvinylpyrrolidone during pyrrole polymerization process. The method for preparingthe above nanoparticles is also provided and comprises the following steps: separately adding polyvinylpyrrolidone with various molecular weights and concentrations into distilled water, stirring anddissolving, adding an initiator, adding pyrrole, stirring until the polymerization is completed, and centrifugally washing to obtain polypyrrole-polyvinylpyrrolidone nanoparticles with various particle sizes. The application of the above polypyrrole-polyvinylpyrrolidone nanoparticles as pharmaceutical carriers or tumor therapeutic materials is also provided. Polyvinylpyrrolidone is grafted on thesurface of nanoparticles to enhance the colloidal stability thereof and to endow the nanoparticles with good blood compatibility and biocompatibility; and the molecular weight and concentration of the polyvinylpyrrolidone are changed to regulate and control the microscopic morphology of the polypyrrole nanoparticles, thus solving the technical problems in the effect of tumor thermotherapy.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a bionano material, in particular to a polypyrrole-polyvinylpyrrolidone nanoparticle and a preparation method and application thereof. Background technique [0002] Photothermal therapy of tumors, that is, photothermal ablation therapy technology, has attracted extensive attention due to its minimally invasive and highly effective features. The basic principle of photothermal therapy is to use near-infrared light absorbers and near-infrared light with strong penetrating power to human tissues to use the high heat generated by the photothermal conversion mechanism to locally heat up tumor tissues and selectively kill tumor tissues. tumor cells. Compared with traditional treatment methods, photothermal therapy is a green treatment method that shows many advantages. For example, NIR laser has good penetrability to biological tissue. In the process of penetrating tissue, the light ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/32A61K47/34A61K41/00A61P35/00
CPCA61K9/5138A61K9/5146A61K41/0052A61P35/00
Inventor 王世革郭丙倩
Owner UNIV OF SHANGHAI FOR SCI & TECH
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