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A new male contraceptive gel system

A gel and system technology, applied in the direction of diseases, liquid delivery, organic active ingredients, etc., can solve the problems of secondary damage to the body, difficult to popularize, etc., and achieve the effect of restoring the ability to ejaculate

Active Publication Date: 2020-07-14
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when it is necessary to restore fertility, it is necessary to inject sodium bicarbonate flushing hydrogel into the vas deferens through a second operation. The operation process will cause secondary damage to the body, so it is difficult to popularize

Method used

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  • A new male contraceptive gel system
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  • A new male contraceptive gel system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: A new type of male contraceptive gel system, its preparation method is:

[0035] The first step: the synthesis of calcium alginate hydrogel: prepare a 2% sodium alginate solution, then take 4.9 g of sodium alginate solution, add 0.1 g of calcium carbonate, and stir evenly at room temperature. Then quickly add 0.2g gluconolactone and mix well for 30s.

[0036] Step 2: Configure 0.1M EDTA solution.

[0037] The third step: configure the PEG and nano-gold mixture, divided into two steps:

[0038] 1) Synthesis of Nano Gold

[0039] Use citric acid reduction method: Take 3ml of 0.029M chloroauric acid solution in a three-necked flask, and heat at a temperature of 160-170°C at 450 rpm. After it boils, add 7ml of 1%wt trisodium citrate solution, continue stirring and heating for 15 minutes, then stop heating, continue stirring for 15 minutes, cool to room temperature, centrifuge twice at 11000rpm, and remove the supernatant. Wash with deionized water, and finally save 10ml...

Embodiment 2

[0043] Example 2: Using transparent tubes with different diameters to simulate the vas deferens

[0044] Use commercially available disposable infusion tubes (1.5mm and 3mm) and PVC transparent tubes (6mm and 8mm) to simulate animal vas deferens with different diameters, and inject PEG / nano-gold, EDTA, PEG into the tube in sequence / Nano-gold, calcium alginate hydrogel four-stage drug, each of which reaches a height of 1cm. After infrared heating for 5 minutes, the time required for the detection system to be completely degraded. The results are shown in the attached drawings figure 2 .

Embodiment 3

[0045] Example 3: Injection of drugs into the vas deferens of rats

[0046] 1) Prepare 10 healthy and fertile SD rats and anesthetize them with a small animal anesthesia machine at a dose of 0.3ml / 100g.

[0047] 2) After the rat is anesthetized, fix its limbs on the operating table with medical glue and expose the abdomen.

[0048] 3) Shave the abdomen, wipe with 75% alcohol, open the abdominal cavity about 3cm longitudinally, clamp the fat and gently pull out one testicle to find the vas deferens.

[0049] 4) Fix a segment of vas deferens with two hemostatic clips, inject drugs in the middle, and inject PEG / nano-gold, EDTA, PEG / nano-gold, and calcium alginate hydrogel with 0.02ml each in sequence from the sperm outflow direction.

[0050] 5) Gently put the testicles and vas deferens back into the abdominal cavity, and do the same on the other side of the vas deferens.

[0051] 6) Finally, the peritoneum and skin are sutured, and the rat is placed in a clean squirrel cage until it wakes ...

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Abstract

The invention provides a novel male contraception gel system. According to the novel male contraception gel system, calcium alginate hydrogel (SA), an EDTA (Ethylene Diamine Tetraacetic Acid) solutionand polyethylene glycol (PEG) / nano gold (AuNps) are combined for the first time and a contraception system can be noninvasively relieved at any time through infrared irradiation. The novel male contraception gel system is a simple, efficient and reversible male contraception method.

Description

Technical field [0001] The invention relates to the field of biological materials, in particular to the establishment of a new male contraceptive gel system. Background technique [0002] With the development and progress of society and the change of people's concepts, the demand for contraception in modern society is also increasing. It is estimated that 85 million unintended pregnancies occur worldwide each year, half of which end in abortion and 13% end in accidental miscarriage. In developing countries, as of 2012, it is estimated that 222 million people have unmet contraceptive needs. For decades, women have shouldered the heavy responsibility of contraception, but long-term use of contraceptives can cause physical damage. But in the field of male contraception---except for condoms and vasectomy, there are few other options. Although condoms can prevent sexually transmitted diseases, condoms can affect the quality of sexual life and have a high failure rate (~19%); althou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/734A61K33/242A61K31/77A61K31/198A61K9/06A61P15/16
CPCA61K9/0019A61K9/0034A61K9/06A61K31/198A61K31/734A61K31/77A61K33/24A61P15/16A61K2300/00
Inventor 王小磊辛洪波鲍伟伟谢琳
Owner NANCHANG UNIV
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