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Lipid carrier with slow-release effect on polyphenols with low water solubility and its preparation method and application

A lipid carrier and low water solubility technology, applied in the field of lipid carrier and its preparation, can solve the problems of poor controllability, single liquid crystal structure, etc., achieve good stability and reduce the number of times of taking

Active Publication Date: 2021-01-08
SHANDONG NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its liquid crystal has a single structure, poor controllability, and the cumulative release rate is only about 80% (80h)

Method used

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  • Lipid carrier with slow-release effect on polyphenols with low water solubility and its preparation method and application
  • Lipid carrier with slow-release effect on polyphenols with low water solubility and its preparation method and application
  • Lipid carrier with slow-release effect on polyphenols with low water solubility and its preparation method and application

Examples

Experimental program
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Embodiment 1

[0037] 1. Experimental part

[0038] 1.1 Instruments and reagents

[0039]

[0040]

[0041]

[0042] 1.2 Drawing of phase diagram

[0043]Take the mixture of isoamyl acetate and PEG 400 with a molar ratio of 9:1, 12:1, and 19:1 as the oil phase, and weigh it according to the mass ratio of the oil phase and lecithin from 10:0 to 0:10. And put it in a colorimetric tube with a stopper, place the colorimetric tube in a water bath at 60-70°C and stir thoroughly, then add double distilled water dropwise with a gradient of water content increasing by 2w%, and mix well. The mixed mixture was placed in a constant temperature water bath at 37°C to balance, and the phenomenon was observed and recorded after the balance was completed. Appropriately extend the equilibration time when approaching the phase boundary. The phase boundary is preliminarily judged by visually observing the color, transparency, viscosity, hardness, etc. of the sample. The configured liquid crystal sa...

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Abstract

The invention discloses a lipid carrier with a sustained-release function for polyphenols medicines with low water solubility, a method for preparing the lipid carrier and application thereof. The lipid carrier is a medicine carrier. The medicine carrier is (lamellar-phase and reversed-hexagonal-phase) lyotropic liquid crystal for loading dihydromyricetin, and soybean lecithin, isoamyl acetate, PEG 400 (polyethylene glycol 400) and water are mixed with one another to form the lyotropic liquid crystal. The isoamyl acetate and the PEG 400 are used as mixed oil phase. A mass ratio of the lecithinto the oil phase to the water is 60:5-35:5-35, a mass ratio of the oil-phase isoamyl acetate to the PEG 400 is 2.9-6.2:1, and the concentration of the dihydromyricetin in the liquid crystal is 0.7-9mg / g. The lipid carrier, the method and the application have the advantages that good sustained-release effects can be realized by the medicine carrier for the dihydromyricetin which is a medicine with low water solubility, and the medicine carrier is high in accumulative release rate.

Description

technical field [0001] The invention belongs to the field of polyphenol drug carriers with low water solubility, and in particular relates to a lipid carrier capable of sustained release of polyphenol drugs with low water solubility, a preparation method and application thereof. Background technique [0002] Dihydromyricetin (DMY), a flavonoid with low water solubility, may have been extracted from the stems and leaves of the vine tea plant. The drug has been proven to have various biological activities and pharmacological effects. For example, antioxidant, antibacterial, anticancer, liver protection, antidiabetic activities, etc. However, due to its low solubility in aqueous solution (0.2 mg / g), dihydromyricetin has low oral bioavailability and low permeability in intestinal tract (Peff=(1.84±0.37)×10 -6 cm / s) and other defects. Therefore, dihydromyricetin is listed as a class IV drug of the biopharmaceutical classification system. In order to improve such defects, some...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K47/24A61K47/14A61K31/352A61P39/06A61P31/04A61P31/10A61P35/00A61P1/16A61P3/10
CPCA61K31/352A61K47/10A61K47/14A61K47/24A61P1/16A61P3/10A61P31/04A61P31/10A61P35/00A61P39/06
Inventor 王仲妮张恒
Owner SHANDONG NORMAL UNIV
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