Tissue repair stent and preparation method and application thereof
A technology for tissue repair and fiber filaments, applied in tissue regeneration, medical science, prostheses, etc., can solve problems such as fibrosis, rejection, and insufficient donors, and achieve tissue regeneration with low possibility and shape easy effect
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no. 1 approach
[0044]The first embodiment of the present invention provides a tissue repair scaffold. In the present invention, the tissue repair scaffold may include hard tissue repair scaffolds such as bone repair scaffolds, and may also be cartilage tissue repair scaffolds, bone-cartilage integrated repair scaffolds, and the like. Among them, the bone-cartilage integrated repair scaffold can take care of cartilage repair and subchondral bone repair in full-thickness cartilage defects.
[0045] The tissue repair scaffold of the present invention includes fiber bundles, and the fiber bundles include one or more than two fiber filaments; at least one of the fiber filaments has functional powder on the surface and / or inside. In the present invention, the compression modulus of the tissue repair scaffold can be adjusted according to the defect site of the tissue repair scaffold. Preferably, the compression modulus of the tissue repair scaffold is in the range of 0.1 MPa to 15 MPa, may be in t...
no. 2 approach
[0073] The second embodiment of the present invention provides a method for preparing a tissue repair scaffold, including the step of preparing the tissue repair scaffold by using 3D printing technology; the tissue repair scaffold is the tissue repair scaffold in the first embodiment. The tissue repair scaffold of the present invention adopts the preparation method of precipitation molding, and the dosage ratio between the biodegradable synthetic polymer compound and the functional powder constituting the tissue repair scaffold can be adjusted accordingly according to the needs of the defect site. The parameters such as the average diameter of the tissue repair scaffold, the pore diameter and porosity of the tissue repair scaffold are conducive to meeting the mechanical performance requirements of different defect sites for the tissue repair scaffold, and the biological activity of each component in the tissue repair scaffold is retained during the printing process. Specificall...
no. 3 approach
[0086] The third embodiment of the present invention provides a specific tissue repair scaffold prepared in the first embodiment or a specific tissue repair scaffold prepared in the second embodiment, that is, a bone-cartilage integrated repair scaffold. The bone-cartilage integrated repair bracket includes: a bone repair layer 1 and a cartilage repair layer 2 connected. In the present invention, the connected bone repair layer 1 and cartilage repair layer 2 may be in direct contact, or may be connected through other feasible active layers.
[0087] like figure 1 As shown, the bone repair layer 1 and the cartilage repair layer 2 contain fiber bundles 3, and the fiber bundles 3 include one or more than two fiber filaments. The fiber filaments are the fiber filaments in the first embodiment. like image 3 As shown, it can be seen from the electron microscope images that at least one of the fiber filaments has functional powder on the surface and / or inside, preferably, the pa...
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