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Preparation method of high-mechanical-strength fiber membrane material for artificial blood vessel

A mechanical strength, artificial blood vessel technology, applied in medical science, prosthesis, etc., can solve the problems of poor mechanical properties of artificial blood vessels, and achieve the effect of improving film-forming properties, mechanical strength, compactness, and compact structure

Inactive Publication Date: 2018-11-02
FOSHAN WANYANG BIOLOGICAL TECH CO LTD
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Problems solved by technology

[0012] Technical problem to be solved by the present invention: Aiming at the problem of poor mechanical properties of artificial blood vessels prepared by existing collagen materials, a preparation method of high mechanical strength fibrous membrane materials for artificial blood vessels is provided

Method used

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  • Preparation method of high-mechanical-strength fiber membrane material for artificial blood vessel

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Embodiment Construction

[0024] In terms of parts by weight, weigh 45 to 50 parts of dissociated fiber slurry, 6 to 8 parts of tetramethylpiperidine, 1 to 2 parts of NaClO and 1 to 2 parts of sodium bromide, place them in a beaker, stir and mix them, and use the mass fraction Adjust the pH to 5.6 with 5% hydrochloric acid, keep it warm at 45-50°C for 1-2 hours, then use 5% sodium hydroxide solution to adjust the pH to 7.0, let it cool down to room temperature, and use a filter with a pore size of 0.25 microns Filter and collect the filter cake, vacuum freeze-dry and collect the modified cellulose; weigh 45 to 50 parts of pH 4.0 disodium hydrogen phosphate-citric acid buffer solution, 3 to 5 parts of tannic acid and Add 10-15 parts of modified cellulose to the beaker, stir and mix and collect the mixed liquid, shake the mixed liquid at 25-35°C for 3-5 hours, let it cool down to room temperature, and then ultrasonicate at 200-300W Disperse for 10 to 15 minutes to collect the dispersion; adjust the pH of...

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Abstract

The invention relates to a preparation method of a high-mechanical-strength fiber membrane material for an artificial blood vessel, and belongs to the technical field of a biological material. According to the technical scheme, primary hydroxyl in carbohydrate cellulose macromolecules is selectively oxidized by a nitrosyl free radical material, a collagen molecular chain is crosslinked to a certain degree through reaction between an oxidized cellulose material and amino of the collagen molecular chain, ad a three-dimensional net-shaped crosslinked structure is formed in the collagen molecule through the oxidized cellulose material, so that the membrane-forming property and the mechanical strength of the fiber membrane material are effectively improved; tannic acid internally contains a large amount of hydroxyl groups and has an antioxidation function, the tannic acid and protein are subjected to multi-point hydrogen bonding, so that connection in a collagen membrane is tight and the structure is changed to be more compact; furthermore, the tannic acid is a polyphenol substance and has tanning property, so a certain filling effect is achieved, the compactness of the collagen membrane is improved and the tensile strength of the modified collagen membrane is obviously improved.

Description

technical field [0001] The invention relates to a preparation method of a high-mechanical-strength fiber membrane material for artificial blood vessels, which belongs to the technical field of biomaterials. Background technique [0002] Textile-based artificial blood vessels are one of the important substitutes for diseased blood vessels. They can be produced and processed by various methods such as weaving, knitting, braiding and non-woven. Textile-based artificial blood vessels have better mechanical properties, more and more uniform surface voids, It is conducive to the growth and adhesion of cells, the forming process is highly controllable and the forming is fast. There are many textile-based artificial blood vessel materials, such as nylon, oren, polyethylene glycol, polyester, Teflon, silk, polytetrafluoroethylene and expanded polytetrafluoroethylene. However, a large number of animal experiments and clinical practice have proved that after artificial blood vessels m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/20A61L27/50
CPCA61L27/20A61L27/24A61L27/507C08L1/04
Inventor 刘茂龙韩桂林
Owner FOSHAN WANYANG BIOLOGICAL TECH CO LTD
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