Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of cr (iii) complex and its preparation method and application

A technology of complexes and ligands, applied in organic chemistry methods, drug combinations, organic chemistry, etc., can solve the problems of low bioavailability, DNA damage, poor water solubility, etc., and achieve the effect of improving water solubility

Active Publication Date: 2021-08-13
TAIYUAN NORMAL UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that some of these complexes are particularly stable in structure, and will not be decomposed by chromium transporters during the transport process, but will be transported from the intestinal tract through the blood system to the interior of the cell with a complete structure, and under the action of intracellular vitamin C Decompose and release chromium ions; some will produce hydroxyl radicals in the process of interacting with vitamin C, causing DNA damage; in addition, its water solubility is poor, and its bioavailability is low (2%), and its use effect is gradually being suspected by people

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of cr (iii) complex and its preparation method and application
  • A kind of cr (iii) complex and its preparation method and application
  • A kind of cr (iii) complex and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation and Structure Characterization of Cr(III) Complexes

[0025] Weigh 0.40g (1.0mmol) Cr(NO 3 )·9H 2 O and 80 μl (63%) concentrated HNO 3 Place in a 100mL round bottom flask, add 40mL of distilled water, heat to reflux to form a dark blue solution; slowly add 1.00g of 1,1'-bis(3-benzoic acid)-4,4'-bipyridine dichloride (2.0mmol ), heated to reflux for 4 hours, stopped the reaction, filtered, and left the resulting filtrate to stand at room temperature to volatilize naturally. After two weeks, purple-red crystals were obtained with a yield of 40%.

[0026] Elemental analysis determination result, by molecular formula C 39 h 42 CrN 3 o 12 Theoretical (%): C, 58.79; H, 5.31; N, 5.27; Experimental (%): C, 58.23; H, 5.13; N, 5.34.

[0027] Crystal determination results (see attached figure 1 ): The simplified structure is [Cr(Bpybc) 1.5 (H 2 O) 3 ]·3H 2 O, where the ligand is Bpybc=1,1'-bis(4-carboxybenzyl)-4,4'-bipyridinium, and the molecular formula is...

Embodiment 2

[0033] Weigh 1.0g (2.5mmol) Cr(NO 3 )·9H 2 O and 200 μl (63%) concentrated HNO 3 Place in a 250mL round bottom flask, add 80mL of distilled water, heat to reflux to form a dark blue solution; slowly add 5.0g of 1,1'-bis(3-benzoic acid)-4,4'-bipyridine dichloride (10mmol) , heated to reflux for 5 hours, stopped the reaction, filtered, and allowed the obtained filtrate to stand still at room temperature to volatilize naturally. After one week, purple-red crystals were obtained with a yield of 42%.

Embodiment 3

[0035] Weigh 0.8g (2.0mmol) Cr(NO 3 )·9H 2 O and 160 μl (63%) concentrated HNO 3 Place in a 250mL round-bottomed flask, add 80mL of distilled water, and heat to reflux to form a dark blue solution; slowly add 5.0g of 1,1'-bis(3-benzoic acid)-4,4'-bipyridine dichloride (10.0mmol ), heated to reflux for about 5 hours, stopped the reaction, filtered, and left the resulting filtrate to stand, and naturally volatilized at room temperature. After two weeks, purple-red crystals were obtained, with a yield of 38%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a metal chromium (III) complex of bipyridine dicarboxylic acid derivatives, a preparation method and biological application thereof, and belongs to the field of drug development and research. Cr (III) complex chemical formula of the present invention is: {[Cr (Bpybc) 1.5 (H 2 O) 3 ]} n , its preparation method: dissolve chromium salt (III) and concentrated nitric acid in water, heat to reflux to form a deep purple chromium solution; add ligand dichloride 1,1'-bis(3-benzoic acid)-4,4'- Bipyridine (Bpybc), stirred and heated to reflux, stopped the reaction, stood still, filtered, and the obtained filtrate was naturally volatilized at room temperature to obtain purple-red crystals. The Cr(III) complex of the present invention can be used in the preparation of hypoglycemic and weight loss drugs. The invention has important significance for developing and promoting the chromium nutrition agent with practical application value and curbing the current increasing obesity and diabetes.

Description

technical field [0001] The invention relates to a metal complex, specifically a Cr(III) complex, a preparation method and application thereof. Background technique [0002] Chromium is an essential trace element in the human body. It is widely distributed in various organs and body fluids in the body. The main function of chromium is to participate in the metabolism of sugar and assist in the secretion and function of insulin. Related studies have shown that organic chromium (III) levels can affect fasting blood glucose, circulating insulin levels, insulin binding capacity, β-cell sensitivity, receptor number, and enzyme activity in glucose metabolism. The amount of Cr(III) in the body gradually decreases with age, and a lack of Cr(III) may lead to a decrease in tissue sensitivity to insulin. At present, the incidence of diabetes is showing a younger trend in the world. [0003] Currently commercially available nutritional chromium supplements are mostly composed of chromi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/22A61P3/04A61P3/10
CPCA61P3/04A61P3/10C07B2200/13C07D213/22
Inventor 高晓丽霍瑞萍韩红斐王婷赵英杰
Owner TAIYUAN NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com