Azaspirone drug injection and its preparation method and application

A technology of spirone injection and tandospirone injection, which is applied in the field of azaspirone drug injection, can solve the problems of poor stability and poor anti-anxiety effect, and achieve high stability, low cost and good stability

Active Publication Date: 2022-05-13
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new type of tandospirone injection, its preparation method and use, so as to solve the problem of poor stability and poor anxiolytic effect of tandospirone pharmaceutical preparations in the prior art, so as to solve the problem of existing tandospirone Improve the stability and anti-anxiety effect of the drug, thereby providing a tandospirone injection with high stability and good anti-anxiety effect

Method used

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  • Azaspirone drug injection and its preparation method and application
  • Azaspirone drug injection and its preparation method and application
  • Azaspirone drug injection and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 20mg of tandospirone citrate, add appropriate amount of water for injection, stir until the solution is clear, add citric acid, and then dilute to 200mL with water for injection; add needle to absorb with activated carbon, filter to remove activated carbon, sterilize, pack That is, 100 water injections of tandospirone were obtained.

Embodiment 2

[0025] Weigh 2g of tandospirone citrate, add an appropriate amount of water for injection, stir until the solution is clear, add hydrochloric acid, and then dilute to 200mL with water for injection; add needles to absorb with activated carbon, filter to remove activated carbon, sterilize, and pack to get ready. Tandospirone water injection 100 pieces.

Embodiment 3

[0027] Weigh 4g of tandospirone citrate, add an appropriate amount of water for injection, stir until the solution is clear, add sodium hydroxide, and then dilute to 200mL with water for injection; add the needle to adsorb with activated carbon, filter to remove the activated carbon, sterilize, and pack That is, 100 water injections of tandospirone were obtained.

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PUM

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Abstract

An azaspironone drug injection and a preparation method and application thereof, characterized in that the azaspironone drug injection comprises an active component of tandospirenone and a stabilizer. Described azapirone drug injection has high stability, good anti-anxiety effect, can meet the needs of clinical patients, can effectively solve children, or have digestive system disorders, or be in coma, convulsions, convulsions and other states and patients with dysphagia ( Such as elderly patients, bedridden patients) should not take tandospirone tablets or capsules orally. The azaspipirone drug injection also has the advantages of low cost, convenient use and the like. The solution of the azaspipirone drug injection is clear, the insoluble particles meet the standard, and the stability is good; there is no visible foreign matter and no abnormal toxicity; and its concentration does not cause toxicity and obvious irritation.

Description

technical field [0001] The invention relates to an azaspirone drug injection, a preparation method and application thereof. Background technique [0002] Anxiety is the most common emotional reaction and a central symptom of all neuroses. With the development of society and the accelerated pace of life, people's demand for anti-anxiety drugs is increasing day by day. The first-generation anti-anxiety drugs represented by meprobamate have poor drug resistance and severe withdrawal symptoms, and the second-generation anti-anxiety drugs of benzodiazepines have psychomotor dysfunction such as muscle relaxation, spasm, and spontaneous movement , memory discrimination dysfunction, psychological and physical dependence and other problems. The third-generation anti-anxiety drugs represented by tandospirone selectively act on the 5-HT1A receptors in the brain, and the action sites are concentrated in the hippocampus, amygdala and other brain limbic systems in the emotional center a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K9/08A61K47/12A61K47/02A61K47/04A61K31/506A61P25/22
CPCA61K47/02A61K47/12A61K9/0019A61K9/08A61K9/19A61K31/506
Inventor 陶建林李晓莉陈刚王平赵思江
Owner SICHUAN CREDIT PHARMA
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