Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application and preparation method of pure magnesium/coating composite

A composite material and coating technology, applied in coating, medical science, surgery, etc., can solve problems such as scarring and fistula obstruction, and achieve the effects of reducing expression, reducing scars, and inhibiting fibroblast proliferation.

Active Publication Date: 2018-09-14
重庆医科大学附属第三医院 +1
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although due in part to the complex nature of the eye selected for implantation surgery, many complications arise from deficiencies in drainage device design and materials
The traditional glaucoma drainage device is permanently placed under the conjunctiva, and the inflammation caused by foreign bodies can lead to postoperative scarring
Traditional titanium alloys cause fibroblast proliferation, resulting in fibrosis and fistula obstruction due to the continuous action of inflammatory mediators and cytokines at the Tenon’s capsule-sclera interface level

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application and preparation method of pure magnesium/coating composite
  • Application and preparation method of pure magnesium/coating composite
  • Application and preparation method of pure magnesium/coating composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 pure magnesium / HA coating composite material

[0037] a. Extrude pure magnesium into rods at 170°C and an extrusion ratio of 20, then cut them into discs with a diameter of 14.5mm and a thickness of 1mm, and use 320-800# sandpaper to polish the surface of the disc. All discs were ultrasonically cleaned in acetone, air dried and weighed.

[0038] b. Then use electrodeposition and conversion coating method to form HA coating, the electrolyte is 0.042mol / L (Ca(NO 3 ) 2 ) and 0.025mol / L (NH 4 h 2 PO 4 ) aqueous solution, the CA / P ratio is 1.67, the pH is 5.0, the electrolysis voltage is 3V, the deposition is 4h, and the coating thickness is 2μm.

[0039] SEM image of pure magnesium / HA coating figure 1 As shown, where Ai is 100 times and Aii is 1000 times.

Embodiment 2

[0040] Embodiment 2 pure magnesium / DCPD coating composite material

[0041] a. Extrude pure magnesium into rods at 180°C and an extrusion ratio of 25, then cut them into discs with a diameter of 14.5mm and a thickness of 1mm, and use 320-800# sandpaper to polish the surface of the disc. All discs were ultrasonically cleaned in acetone, air dried and weighed.

[0042] b. Then use electrodeposition and conversion coating method to form DCPD coating, the electrolyte is 3.1% disodium hydrogen phosphate (Na 2 HPO4) and 5.3% calcium nitrate (Ca(NO 3 ) 2 ) solution, deposition conditions: pH 3.5, deposition at 45°C for 3 hours, coating thickness of 3 μm.

[0043] SEM image of pure magnesium / DCPD coating figure 2 shown. Among them, Bi is 400 times, and Bii is 1000 times.

[0044] HA and DCPD coatings are formed by chemical bonds between calcium phosphate and magnesium matrix.

Embodiment 3

[0045] Embodiment 3 pure magnesium / DCPD+SA coating composite material

[0046] a. The pure magnesium / DCPD coating composite material prepared in Example 2 is treated with stearic acid to form a pure magnesium / DCPD+SA coating composite material, soaked in 0.5mol / L stearic acid ethanol solution for 1.5h, DCPD The +SA coating depends on hydrogen bonding and physical adsorption, and the thickness of the DCPD+SA coating is 4 μm. .

[0047] SEM image of pure magnesium / DCPD+SA coating image 3 shown. Among them, Ci is 100 times, and Cii is 1000 times.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention relates to application of pure magnesium / coating composite in the preparation of glaucoma drainage devices; a glaucoma drainage device made with the pure magnesium / coating composite candegrade and be absorbed by tissues autonomously; it is fully shown that the pure magnesium / coating composite can inhibit the proliferation of Tenon's capsule fibroblasts and decrease scar; magnesium ions released during degradation can protect visual nerves. Compared with traditional titanium alloy, the pure magnesium / coating composite causes significantly low cytotoxicity to the fibroblasts, andcan effectively inhibit the proliferation of Tenon's fibroblasts, reduce specific protein alpha-SMA expression and inhibit activity of the fibroblasts.

Description

technical field [0001] The invention belongs to the technical field of medical implant materials, and relates to the application and preparation method of pure magnesium / coating composite materials. Background technique [0002] Glaucoma is the second leading cause of blindness and the leading cause of irreversible blindness worldwide. my country is the most populous country in the world, and glaucoma is one of the main blinding eye diseases in our country. The impact of visual dysfunction and blindness caused by glaucoma cannot be ignored. The last decade has seen the advent of minimally invasive glaucoma surgery, which is an important treatment option for glaucoma, and more recently, implantable devices, which are the world's most advanced treatments for all forms of glaucoma, especially for refractory glaucoma. Operation. The first generation of microdissection devices were made of titanium, and since then other materials have been introduced. [0003] However, there m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/02A61L31/08A61L31/14A61L31/16
CPCA61L31/022A61L31/08A61L31/086A61L31/14A61L31/148A61L31/16A61L2300/102A61L2300/604A61L2420/02
Inventor 李翔骥王勇
Owner 重庆医科大学附属第三医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com