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Local field estimation method based on magnetic resonance dipole field space distribution

A magnetic resonance dipole field, spatial distribution technology, applied in medical science, diagnostic signal processing, sensors, etc., can solve the problems of phase residual, unfavorable clinical application of QSM technology, inability to obtain brain diagnostic information, etc. Effect

Inactive Publication Date: 2018-09-14
XIAMEN UNIV
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Problems solved by technology

However, the use of masks in different directions will lead to serious loss of brain tissue, which will prevent us from obtaining complete brain diagnostic information, which is not conducive to the clinical application of QSM technology
Therefore, when removing the background field of the strong magnetic susceptibility area under multi-directional imaging and accurately estimating the local field, the above methods are insufficient, or the brain tissue is seriously missing, or the phase residue is serious, and further improvement is needed

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  • Local field estimation method based on magnetic resonance dipole field space distribution
  • Local field estimation method based on magnetic resonance dipole field space distribution
  • Local field estimation method based on magnetic resonance dipole field space distribution

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Embodiment Construction

[0040] The following embodiments will further illustrate the present invention in conjunction with the accompanying drawings.

[0041] figure 1 Figures of human brain data in different imaging orientations are given. The invention can effectively remove background field, obtain accurate local field, and protect the integrity of brain tissue at the same time. The specific implementation process of the method is as follows:

[0042] 1) First, numerical simulation experiments are carried out. Create a 128ⅹ128ⅹ64 matrix, embed a large ellipsoid in the matrix to simulate the human brain, and regenerate 5 small ellipsoids in the large ellipsoid to simulate the sinuses, blood vessels, substantia nigra, globus pallidus and caudate nucleus respectively, corresponding The magnetic susceptibility is 9.4ppm, 0.3ppm, 0.16ppm, 0.1ppm and 0.05ppm, the magnetic susceptibility of the rest of the brain area is set to 0ppm, and another ellipsoid with a magnetic susceptibility value of 9.4ppm ...

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Abstract

The invention discloses a local field estimation method based on magnetic resonance dipole field space distribution, and relates to nuclear magnetic resonance quantitative magnetic susceptibility imaging. The method comprises the following steps: estimating a writhing number based on a phase image; estimating a Gaussian convolution kernel standard deviation Sigma (r) modulated by the amplitude, gradient and writhing number of the phase image; dividing an interested region into a high magnetic susceptibility variation region and a uniform susceptibility region according to space information; regulating the Gaussian convolution kernel standard deviation voxel by voxel according to the space information of the phase image, namely the amplitude, gradient and writhing number of the phase image,and further estimating the weight of a sphere center point and other points. The method can effectively remove background field of a strong magnetic susceptibility region in different imaging directions and accurately estimates local field, and meanwhile keeps the completeness of brain tissue, and the effect of the method is obviously superior to that of the existing method.

Description

technical field [0001] The invention relates to nuclear magnetic resonance quantitative magnetic susceptibility imaging, in particular to a local field estimation method based on the spatial distribution of magnetic resonance dipole fields. Background technique [0002] Magnetic susceptibility is an inherent property of matter, which can reflect the degree of magnetization of biological tissue under the action of an external magnetic field, and is one of the main signal sources of Magnetic Resonance Imaging (MRI). Since the magnetic susceptibility distribution of biological tissues is affected by factors such as tissue iron content, calcification, and blood oxygen saturation, the magnetic susceptibility varies between different tissues of the human body, between normal tissues and diseased tissues. The gray matter in the human brain has iron deposition, which is paramagnetic, and the magnetic susceptibility value is positive; oxygenated hemoglobin in blood vessels is diamagn...

Claims

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Application Information

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IPC IPC(8): A61B5/055
CPCA61B5/055A61B5/72
Inventor 包立君方金生陈忠
Owner XIAMEN UNIV
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