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Health capsules capable of alleviating pain and promoting sleep and preparation method thereof

A technology for health care capsules and sleep aids, applied in capsule delivery, pharmaceutical formulations, non-central analgesics, etc., can solve problems such as treating the symptoms but not the root cause, increasing the dosage of melatonin, etc., to relieve pain, easy to obtain materials, and improve utilization. Effect

Active Publication Date: 2018-09-07
GUIZHOU SHENQI PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its functional ingredient is melatonin, which only helps patients fall asleep through the sleeping effect of melatonin. For patients with diseases and severe body pain who cannot fall asleep, the pain cannot be relieved. Forcibly helping sleep requires increasing melatonin Excessive use of melatonin will cause the patient to feel dizzy and dizzy after getting up the next morning, and the pain in the body will not disappear, so that the treatment can only treat the symptoms but not the root cause

Method used

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  • Health capsules capable of alleviating pain and promoting sleep and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: preparation of health-care capsule

[0022] Take 300g of phoenix clothes and add water with a mass fraction of 20 times, extract at 100°C for 4h, then centrifuge at 3500r / min for 25min, take the supernatant, add water with a mass fraction of 8 times, extract at 100°C for 1h, and then use 3500r / min / min centrifugation for 25min, take the supernatant, combine the two filtrates to obtain a mixed extract; place the mixed extract in a rotary evaporator at 70°C, evaporate and concentrate to 1 / 10 of the volume of the original mixed extract; add to the concentrate Trypsin with a mass ratio of 2% was hydrolyzed for 4 hours, and the hydrolyzed product was spray-dried at an air inlet temperature of 230°C and a pump speed of 65r / min to obtain a hydrolyzed powder of phoenix clothes. After sterilizing under the lamp for 40 minutes, the capsules were filled under aseptic conditions.

Embodiment 2

[0023] Embodiment 2: preparation of health-care capsule

[0024] Take 500g of phoenix clothes and add water with a mass fraction of 25 times, extract at 100°C for 4h, then centrifuge at 3700r / min for 25min, take the supernatant, add water with a mass fraction of 9 times, extract at 100°C for 1.5h, and then use Centrifuge at 3700r / min for 25min, take the supernatant, combine the two filtrates to obtain a mixed extract; place the mixed extract in a rotary evaporator at 75°C, evaporate and concentrate to 1 / 15 of the volume of the original mixed extract; Add trypsin with a mass ratio of 2.5% to hydrolyze for 4 hours, spray-dry the hydrolyzed product at an air inlet temperature of 270°C, and a pump speed of 70r / min to obtain Phoenix clothes hydrolyzed powder, then add 0.0025g of melatonin, mix well, and After sterilization under 33W ultraviolet lamp for 38 minutes, the capsules were filled under aseptic conditions.

Embodiment 3

[0025] Embodiment 3: preparation of health-care capsule

[0026] Take 600g of phoenix clothes and add 30 times the mass fraction of water, extract at 100°C for 3h, then use 4000r / min centrifugation for 30min, take the supernatant, add 10 times the mass fraction of water to the filter residue, extract at 100°C for 1h, and then use 4000r / min / min centrifuged for 30min, took the supernatant, combined the two filtrates to obtain a mixed extract; placed the mixed extract in a rotary evaporator at 80°C, evaporated and concentrated to 1 / 20 of the volume of the original mixed extract; added to the concentrate Trypsin with a mass ratio of 3% was hydrolyzed for 3 hours, and the hydrolyzed product was spray-dried at an air inlet temperature of 280°C and a pump speed of 80r / min to obtain a hydrolyzed powder of phoenix clothes, then added 0.002g of melatonin, mixed evenly, After sterilizing under ultraviolet light for 35 minutes, the capsules were filled under aseptic conditions.

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Abstract

The invention provides health capsules capable of alleviating pain and promoting sleep and a preparation method thereof. The health capsules are prepared from the raw materials of 300-600 parts of gallus gallus domesticus brisson and 0.002-0.003 part of melatonin. The preparation method comprises the step of hydrolyzing the gallus gallus domesticus brisson to enable active components of the gallusgallus domesticus brisson to be released, so that the utilization rate of effective components of the gallus gallus domesticus brisson is increased. The source of raw material of the gallus gallus domesticus brisson is easy and convenient to obtain, high in yield, and low in cost, so that the cost of products can be greatly reduced. The hydrolyzed components of the gallus gallus domesticus brisson and the melatonin are compounded and researched, so that the consumption of the melatonin can be reduced, for patients suffering from diseases and pains and being unable to sleep, the diseases and the pains can be alleviated, and the patients can go to sleep peacefully. The health capsules do not influence the mind state of the patients the next day, and the effect of thoroughly treating the diseases can be achieved. In addition, the detection method can simply, quickly and effectively detect the health capsules, and the product quality can be guaranteed.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an analgesic and sleep-promoting health-care capsule and a preparation method thereof. Background technique [0002] Melatonin, also known as melatonin and pineal gland, is a neurohormone mainly secreted by the pineal gland of mammals, and other tissues other than the pineal gland also secrete the substance. American dermatologists isolated and proved its biological activity from bovine pineal gland extract for the first time. Melatonin has a wide range of physiological and pharmacological activities. Its main role is to regulate circadian rhythm, sleep-wake biological rhythm phase transition, improve sleep, and also has anti-oxidation, free radical scavenging, anti-inflammation, anti-apoptosis, lower body temperature, and tumor inhibition. Growth, inhibition of reproductive system function, improvement of memory, treatment of dementia, anti-aging, anti-anx...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/57A61K9/48A61P29/00A61P25/20A61K31/4045
CPCA61K9/48A61K31/4045A61K35/57A61P25/20A61P29/00A61K2300/00
Inventor 张芝庭张涛涛
Owner GUIZHOU SHENQI PHARMA RES INST
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