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Medicine composition for preventing and treating depression and insomnia diseases and preparation method and application thereof

A composition and disease technology, applied in the fields of health care products and medicine, can solve the problems of irreversible adsorption of samples, time-consuming and laborious separation of active components of jujube seeds, and low yield, and achieve the effects of rapid separation, large preparation amount and high efficiency.

Inactive Publication Date: 2018-09-07
TIANJIN MEDICAL UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The second object of the present invention is to provide a method for preparing magnolialine and spinosin by high-speed counter-current chromatography, which can extract pure magnolialine and spinosin from the jujube seed medicinal material, so as to overcome the problem of extraction in the prior art. Separating the active components of jujube seed is time-consuming and labor-intensive, immobilization has irreversible adsorption to the sample, and the yield is low

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  • Medicine composition for preventing and treating depression and insomnia diseases and preparation method and application thereof
  • Medicine composition for preventing and treating depression and insomnia diseases and preparation method and application thereof
  • Medicine composition for preventing and treating depression and insomnia diseases and preparation method and application thereof

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Embodiment 1

[0033] 1. Preparation of crude extract:

[0034] Grind 250g jujube kernels, pass through a 40-mesh sieve, degrease with petroleum ether, add 1200ml, 800ml, 600ml of 70% ethanol aqueous solution, heat and reflux for extraction 3 times, each time for 1 hour, filter, and combine the extracts , the filtrate is concentrated with ethanol until it has no alcohol smell, then dissolved with 2 times the amount of water, extracted 5 times with n-butanol, the extract is concentrated under reduced pressure, and the solvent is recovered to obtain the n-butanol crude extract, which is the sample to be separated. figure 1 shown.

[0035] 2. Using high-speed countercurrent chromatography to separate magnolialine, spinosin, and 6″’-feruloylspinosin:

[0036] Take n-butanol, ethyl acetate and water at a volume ratio of 2:3:5, place them in a separatory funnel to prepare a two-phase solvent system, take the upper phase as the stationary phase, and the lower phase as the mobile phase; fill the st...

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Abstract

The invention discloses a medicine composition for preventing and treating the depression and insomnia diseases and a preparation method and application thereof. The medicine composition is prepared from active ingredients of magnoflorine and spinosin in proportion. The invention further provides a method for separating and preparing magnoflorine and spinosin from spina date seeds through high-speed counter-current chromatography. According to the separation conditions, in a solvent system, the ratio of n-butyl alcohol to ethyl acetate to water is (1-3):(1-5):(2-7), the upper phase is a stationary phase, and the lower phase is a mobile phase. The preparation method has the advantages of being good in separation effect, large in preparation amount, low in loss, easy and convenient to operate, economical and environmentally friendly. Experimental studies of animal pharmacodynamics show that the composition has a remarkable improving and treating function on the depression and insomnia diseases.

Description

technical field [0001] The invention belongs to the fields of medicine and health products, and relates to a pharmaceutical composition, a preparation method thereof and an application in treating depression and insomnia. Background technique [0002] With the acceleration of the pace of life, the incidence of insomnia and depression gradually increased. 90% of patients with depression are accompanied by physical symptoms such as insomnia and sleep disorders, and insomnia is a key factor causing the onset and recurrence of depression. However, there are no clear diagnosis and treatment methods for insomnia and depression at present, and the onset time is long and easy to relapse, and patients need to take medication for a long time. Although many antidepressant western medicines are effective, they have a single target and cannot improve the symptoms of depression accompanied by insomnia, and their side effects will aggravate some physical symptoms. Traditional Chinese med...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/473A61P25/24A61P25/20C07D221/18C07H1/08C07H7/06
CPCA61K31/473A61K31/7048A61P25/20A61P25/24C07D221/18C07H1/08C07H7/06A61K2300/00
Inventor 乔卫曹冰雁赵浩东
Owner TIANJIN MEDICAL UNIV
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