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Fat-soluble glabridin compound whitening agent and application thereof

A glabridin and fat-soluble technology, which is applied in the direction of pharmaceutical formulas, cosmetic preparations, skin care preparations, etc., can solve problems such as consumer allergies, mercury poisoning, and freckle-removing cosmetics with little effect, to prevent melanin precipitation, Delay skin oxidation and promote the effect of melanocyte differentiation

Active Publication Date: 2018-09-07
亿利耐雀生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Almost all freckle-removing cosmetics have little effect, and some unscrupulous merchants even add large doses of toxic and harmful substances such as hydroquinone, hormones, or aminomercuric chloride to cosmetics for the purpose of freckle-removing, causing severe allergies or mercury poisoning to some consumers

Method used

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  • Fat-soluble glabridin compound whitening agent and application thereof
  • Fat-soluble glabridin compound whitening agent and application thereof
  • Fat-soluble glabridin compound whitening agent and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: Weigh 40% Glycyrrhizae glabra extract, 20% tetrahydroxychalcone, 20% ubiquinone and 20% endothelin antagonist by mass parts, grind each component, and grind the mixture 100 mesh sieve to obtain fat-soluble glabridin compound whitening agent.

Embodiment 2

[0036] Embodiment 2: Weigh 45% Glycyrrhiza glabra extract, 15% tetrahydroxychalcone, 25% ubiquinone and 15% endothelin antagonist by mass parts, grind each component, and pass the pulverized mixture 100 mesh sieve to obtain fat-soluble glabridin compound whitening agent.

Embodiment 3

[0037] Embodiment 3: Weigh 35% Glycyrrhizae glabra extract, 25% tetrahydroxychalcone, 15% ubiquinone and 25% endothelin antagonist by mass parts, grind each component, and grind the mixture 100 mesh sieve to obtain fat-soluble glabridin compound whitening agent.

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PUM

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Abstract

The invention discloses a fat-soluble glabridin compound whitening agent and application of the agent in cosmetics. The compound whitening agent is prepared from the following active ingredients in byweight percent: 30-50 percent of glycyrrhiza glabra extract, 10-30 percent of tetrahydroxychalcone, 10-30 percent of ubiquinone and 10-30 percent of an endothelin antagonist. The compound whitening agent has main whitening action mechanisms of inhibiting the activity of tyrosinase, inhibiting the activity of DOPA chrome tautomerase and obstructing indole-5,6-quinone polymerization, so that melanogenesis can be obstructed, differentiation of melanophores can be reduced, and the aims of whitening skin, lightening spots and improving dark skin color can be achieved. The compound whitening agenthas a simple and practical formula and a good whitening and spot-lightening effect, is environmentally friendly and safe since natural products are adopted, is mild and nonirritant in use, and can overcome the defect in an existing whitening agent.

Description

technical field [0001] The invention relates to a cosmetic formulation, in particular to a fat-soluble glabridin compound whitening agent and an application thereof. Background technique [0002] The uneven distribution and accumulation of melanocytes on the surface of the skin can lead to dull skin and dark spots. The main pathway leading to the formation of melanin is that tyrosinase converts tyrosine into dopa, which is further oxidized into dopaquinone, and finally forms melanin. Over the years, the cosmetics industry has been constantly seeking technological breakthroughs and is committed to developing safe and efficient whitening ingredients. [0003] Currently common whitening mechanisms and raw materials include: inhibiting tyrosinase activity, such as glutathione and glabridin; complexing copper ions to prevent DHI polymerization, such as phytic acid, kojic acid and their derivatives; reducing melanin, such as VC and its derivatives; accelerate the degradation of ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/35A61Q19/02
CPCA61K8/35A61K8/355A61K2800/592A61K2800/5922A61K2800/782A61Q19/02A61K8/9789
Inventor 魏元刚刘亿宁杨永安钟慧左婧
Owner 亿利耐雀生物科技有限公司
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