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Bio-based self-repair gel based on boric acid ester bond

A bio-based, self-healing technology, applied in the field of functional polymer materials, can solve problems such as low repair efficiency, harsh repair conditions, and self-healing gel biotoxicity, and achieve short repair process, mild repair conditions, and excellent biological properties. compatibility effect

Inactive Publication Date: 2018-09-04
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, many studies have reported the preparation of self-healing hydrogels, but there are still problems such as potential biotoxicity of self-healing gels, harsh repair conditions, and low repair efficiency.

Method used

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  • Bio-based self-repair gel based on boric acid ester bond
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Examples

Experimental program
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Effect test

Embodiment 1

[0023] A method for preparing a bio-based self-repair gel based on a borate bond, the method comprising the steps of:

[0024] (1) Synthesis of alginic acid-phenylboronic acid (Alg-APBA) modified biological macromolecules;

[0025] Weigh 1.98g of sodium alginate (Alg) into a three-necked flask, add 100mL of deionized water and stir to dissolve for 2 hours; add 1.92g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt salt (EDC·HCl), 2.30g N-hydroxysuccinimide (NHS) activation for 30mins; weigh 0.68g 3-aminophenylboronic acid (APBA) in a beaker and add 100mL deionized water, and drop its aqueous solution Add it to the Alg solution and react at room temperature for 24 hours. The product is first precipitated with ethanol, and then purified by dissolving the ethanol precipitate with deionized water. After repeated three times, it is dialyzed in deionized water for 7 days. After freeze-drying, light yellow flocculent fibers are obtained, which are Alg-APBA modified biomacromole...

Embodiment 2

[0031] A method for preparing a bio-based self-repair gel based on a borate bond, the method comprising the steps of:

[0032] (1) Synthesis of polyglutamic acid-phenylboronic acid (γ-PGA-APBA) modified biological macromolecules;

[0033] Weigh 1.29g of polyglutamic acid (γ-PGA) in a three-necked flask, add 100mL of deionized water and then mechanically stir to dissolve for 2h; add 1.92g of 1-(3-dimethylaminopropyl)-3-ethylcarbodi imine hydrochloride (EDC·HCl), 2.30g N-hydroxysuccinimide (NHS) activation for 30mins; weigh 0.68g 3-aminophenylboronic acid (APBA) in a beaker and add 100mL deionized water, and The aqueous solution was added dropwise to the γ-PGA solution. After reacting at room temperature for 24 hours, the product was first precipitated with ethanol, and then purified by dissolving the ethanol precipitate with deionized water. After repeated three times, it was dialyzed in deionized water for 7 days. After freeze-drying, flocculent fibers were obtained, namely γ...

Embodiment 3

[0041] A method for preparing a bio-based self-repair gel based on a borate bond, the method comprising the steps of:

[0042] (1) Synthesis of hyaluronic acid-phenylboronic acid (HA-APBA) modified biomacromolecules;

[0043] Weigh 3.79g of hyaluronic acid (HA) into a three-necked flask, add 100mL of deionized water, and then mechanically stir to dissolve for 2h; add 1.92g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt salt (EDC·HCl), 2.30g N-hydroxysuccinimide (NHS) activation for 30mins; weigh 0.68g 3-aminophenylboronic acid (APBA) in a beaker and add 100mL deionized water, and drop its aqueous solution After adding to γ-PGA solution and reacting at room temperature for 24 hours, the product was first precipitated with ethanol, and then purified by dissolving the ethanol precipitate with deionized water. After repeated three times, it was dialyzed in deionized water for 7 days. After freeze-drying, flocculent fibers were obtained, namely HA-APBA, with a grafting rate...

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Abstract

The invention discloses a bio-based self-repair gel based on a boric acid ester bond. The preparation method of the bio-based self-repair gel includes the steps of: (1) taking 3-aminobenzeneboronic acid as the functional group, and modifying a biomacromolecule containing carboxyl to obtain a benzeneboronic acid based biomacromolecule; (2) modifying guar gum with a quaternary ammonium salt to obtain cationic guar gum; and (3) mixing the benzeneboronic acid based biomacromolecule prepared by step (1) with the cationic guar gum prepared by step (2), and utilizing the reversible ester bond formedbetween benzeneboronic acid and guar gum and the electrostatic interaction of positive and negative charges to prepare the bio-based self-repair gel with a double cross-linked network structure. The bio-based self-repair gel provided by the invention has excellent biocompatibility, biodegradability and self-repairability, and has broad application prospects in biomedicine, functional devices, sensing and other fields.

Description

technical field [0001] The invention relates to the technical field of functional polymer materials, in particular to a bio-based self-healing gel prepared by participating in a reaction with bio-based macromolecules. Background technique [0002] Self-healing gels are gels that can recover after being damaged to a certain extent. Similar to other self-healing materials, the self-healing gel has two main characteristics; one is that it has a mobile phase that can flow near the damaged area, so that after the gel is damaged, it can form a "bridge" at the damaged area to complete the repair function. Second, because there are water molecules in the gel system, it promotes the formation of the mobile phase and can better complete the repair process. The repair process is mainly divided into active and passive repair methods. Active repair or passive repair depends on whether external intervention (light, heat, force, etc.) is required to complete the repair process and restore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08L5/04C08L5/00C08L77/04C08L5/08
CPCC08J3/246C08J2305/04C08J2305/08C08J2377/04C08J2405/00
Inventor 施冬健黄河李雅瑜陈明清张洪吉
Owner JIANGNAN UNIV
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