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Rare earth-organic porous material, preparation method thereof and application thereof in detection of nerve disease marker glutamic acid

A technology of porous materials and rare earths, applied in the field of fluorescent probes for detecting neurological disease marker glutamate, can solve the problems of time-consuming detection, complicated operation, expensive instruments, etc., and achieve the effects of good stability, simple process and mild conditions

Active Publication Date: 2018-08-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional glutamic acid detection methods cannot be widely used due to their shortcomings such as complicated operation, expensive equipment, and time-consuming detection.

Method used

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  • Rare earth-organic porous material, preparation method thereof and application thereof in detection of nerve disease marker glutamic acid
  • Rare earth-organic porous material, preparation method thereof and application thereof in detection of nerve disease marker glutamic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Terbium nitrate hexahydrate (Tb(NO 3 ) 3 ·6H 2 O) and 2-hydroxyterephthalic acid, a rare earth-organic porous material (C 26 h 30 Tb 3 o 22 )·DMF·(H 2 O) 3 , its specific synthetic route is as follows:

[0023] 2-Hydroxyterephthalic acid, terbium nitrate hexahydrate and 2-fluorobenzoic acid were dissolved in N,N-dimethylformamide respectively to make a 0.01mol / L solution. Then take 0.73mL of 2-hydroxyterephthalic acid solution, 0.73mL of terbium nitrate hexahydrate solution and 5.84mL of 2-fluorobenzoic acid solution, mix them evenly, and add them into a closed container; then add 0.6mL of deionized water and 0.2mL of nitric acid, sealed, reacted in a constant temperature oven at 110°C for 3 days, cooled to room temperature with the furnace, centrifuged to separate the solid and liquid, washed the solid with N,N-dimethylformamide and ethanol, filtered and dried to obtain the target Product (C 26 h 30 Tb 3 o 22 )·DMF·(H 2 O) 3 , the crystals are pale yello...

Embodiment 2

[0030] Europium nitrate hexahydrate (Eu(NO 3 ) 3 ·6H 2 O) and 2-hydroxyterephthalic acid, a rare earth-organic porous material (C 26 h 30 Eu 3 o 22 )·DMF·(H 2 O) 3 , its specific synthetic route is as follows:

[0031] 2-Hydroxyterephthalic acid, europium nitrate hexahydrate and 2-fluorobenzoic acid were respectively dissolved in N,N-dimethylformamide to make a 0.01 mol / L solution. Then take 0.73mL of 2-hydroxyterephthalic acid solution, 0.73mL of europium nitrate hexahydrate solution and 5.84mL of 2-fluorobenzoic acid solution, mix them evenly, and add them into a closed container; then add 0.6mL of deionized water and 0.2mL of nitric acid, sealed, reacted in a constant temperature oven at 110°C for 3 days, cooled to room temperature with the furnace, centrifuged to separate the solid and liquid, washed the solid with N,N-dimethylformamide and ethanol, filtered and dried to obtain (C 26 h 30 Eu 3 o 22 )·DMF·(H 2 O) 3 , the yield rate is 51%, and the BET area is ...

Embodiment 3

[0037] Gadolinium nitrate hexahydrate (Gd(NO 3 ) 3 ·6H 2 O) and 2-hydroxyterephthalic acid, a rare earth-organic porous material (C 26 h 30 Gd 3 o 22 )·DMF·(H 2 O) 3 , its specific synthetic route is as follows:

[0038] Dissolve 2-hydroxyterephthalic acid, gadolinium nitrate hexahydrate, and 2-fluorobenzoic acid in N,N-dimethylformamide, respectively, to make 0.01mol / L solutions. Then take 0.73mL of 2-hydroxyterephthalic acid solution, 0.73mL of gadolinium nitrate hexahydrate solution and 5.84mL of 2-fluorobenzoic acid solution, mix them evenly, and add them into a closed container; then add 0.6mL of deionized water and 0.2mL of nitric acid, sealed, reacted in a constant temperature oven at 110°C for 3 days, cooled to room temperature with the furnace, centrifuged to separate the solid and liquid, washed the solid with N,N-dimethylformamide and ethanol, filtered and dried to obtain the rare earth- Organic porous materials (C 26 h 30 Gd 3 o 22 )·DMF·(H 2 O) 3 , ...

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Abstract

The invention relates to a rare earth-organic porous material, a preparation method thereof and application thereof in the detection of nerve disease marker glutamic acid. Through the technical scheme, the preparation method comprises the following steps: dissolving Ln(NO3)3.6H2O, hydroxyterephthalic acid and 2-fluorobenzoic acid into a mixed solution of an organic solvent, water and nitric acid;sealing after ultrasonic uniformity, putting the mixture in a baking oven at the temperature of 110 DEG C for 3 d; naturally cooling to room temperature, washing, filtering and drying to obtain the rare earth-organic porous material. The rare earth-organic porous material prepared in the invention has obvious fluorescent response to the nerve disease marker glutamic acid, rare earth luminescence is taken as an interior label, the luminescence of organic molecules is taken as a detection signal, high-selective detection for glutamic acid can be realized, and then the material can be used for early prevention and diagnosis of nerve diseases.

Description

technical field [0001] The present invention relates to a kind of preparation method and application of rare earth-organic porous material, specifically, relate to Ln 3+ (Ln=Eu, Tb, Gd) and hydroxyterephthalic acid-structured rare earth-organic porous material are used as fluorescent probes for detecting neurological disease marker glutamic acid. Background technique [0002] Glutamate (Glu) is an important excitatory neurotransmitter, which plays an important role in the normal functional activities and neuromodulation of the central nervous system. Glutamate carries out its own transport and signal transduction through a large number of "carriers" to complete the regulation of the physiological and pathological state of the body, so it is closely related to the occurrence of many diseases. The increase of glutamate concentration indicates the possible occurrence of some neuropathies, such as acute ischemic stroke, Parkinson's disease, epilepsy and Alzheimer's disease, so ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00C09K11/06G01N21/64
CPCC07B2200/13C07F5/003C09K11/06C09K2211/182G01N21/6486
Inventor 崔元靖夏体锋杨雨钱国栋
Owner ZHEJIANG UNIV
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